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Oral Probiotic Microcapsule Formulation Ameliorates Non-Alcoholic Fatty Liver Disease in Bio F1B Golden Syrian Hamsters
Bhathena, Jasmine Martoni, Christopher Kulamarva, Arun Tomaro-Duchesneau, Catherine Malhotra, Meenakshi Paul, Arghya Urbanska, Aleksandra Malgorzata Prakash, Satya
Bhathena, Jasmine
Martoni, Christopher
Kulamarva, Arun
Tomaro-Duchesneau, Catherine
Malhotra, Meenakshi
Paul, Arghya
Urbanska, Aleksandra Malgorzata
Prakash, Satya
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Abstract
The beneficial effect of a microencapsulated feruloyl esterase producing Lactobacillus fermentum ATCC 11976 formulation for use in non-alcoholic fatty liver disease (NAFLD) was investigated. For which Bio F1B Golden Syrian hamsters were fed a methionine deficient/choline devoid diet to induce non-alcoholic fatty liver disease. Results, for the first time, show significant clinical benefits in experimental animals. Examination of lipids show that concentrations of hepatic free cholesterol, esterified cholesterol, triglycerides and phospholipids were significantly lowered in treated animals. In addition, serum total cholesterol, triglycerides, uric acid and insulin resistance were found to decrease in treated animals. Liver histology evaluations showed reduced fat deposits. Western blot analysis shows significant differences in expression levels of key liver enzymes in treated animals. In conclusion, these findings suggest the excellent potential of using an oral probiotic formulation to ameliorate NAFLD.
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2013-03-12
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Public Library of Science
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Bhathena J, Martoni C, Kulamarva A, Tomaro-Duchesneau C, Malhotra M, Paul A, et al. (2013) Oral Probiotic Microcapsule Formulation Ameliorates Non-Alcoholic Fatty Liver Disease in Bio F1B Golden Syrian Hamsters. PLoS ONE 8(3): e58394. http://dx.doi.org/10.1371/journal.pone.0058394