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A Convenient Way to Quinoxaline Derivatives through the Reaction of 2-(3-Oxoindolin-2-yl)-2-phenylacetonitriles with Benzene-1,2-diamines
Aksenov, Alexander V. Arutiunov, Nikolai A. Aksenov, Dmitrii A. Samovolov, Artem V. Kurenkov, Igor A. Aksenov, Nicolai A. Aleksandrova, Elena A. Momotova, Daria S. Rubin, Michael
Aksenov, Alexander V.
Arutiunov, Nikolai A.
Aksenov, Dmitrii A.
Samovolov, Artem V.
Kurenkov, Igor A.
Aksenov, Nicolai A.
Aleksandrova, Elena A.
Momotova, Daria S.
Rubin, Michael
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Abstract
Microwave-assisted reaction between 2-(3-oxoindolin-2-yl)-2-phenylacetonitriles andbenzene-1,2-diamines leads to the high-yielding formation of the corresponding quinoxalines as sole, easily isolaable products. The featured transformation involves unusual extrusion of phenylacetonitrile molecule and could be performed in a short sequence starting from commonly available indoles and nitroolefins.
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Date
2022-09-22
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Publisher
MDPI
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Keywords
Cyclization, Quinoxalines, Microwave synthesis
Citation
Aksenov, A.V.; Arutiunov, N.A.; Aksenov, D.A.; Samovolov, A.V.; Kurenkov, I.A.; Aksenov, N.A.; Aleksandrova, E.A.; Momotova, D.S.; Rubin, M. A Convenient Way to Quinoxaline Derivatives through the Reaction of 2-(3-Oxoindolin-2-yl)-2-phenylacetonitriles with Benzene-1,2-diamines. Int. J. Mol. Sci. 2022, 23, 11120. https://doi.org/10.3390/ijms231911120