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Synthesis and Interactions of 7-Deoxy-, 10-Deacetoxy, and 10-Deacetoxy-7-Deoxypaclitaxel with NCI/ADR-RES Cancer Cells and Bovine Brain Microvessel Endothelial Cells
Ge, Haibo Vasandani, Veena Huff, Jacquelyn K. Audus, Kenneth L. Himes, Richard H. Seelig, Anna Georg, Gunda I.
Ge, Haibo
Vasandani, Veena
Huff, Jacquelyn K.
Audus, Kenneth L.
Himes, Richard H.
Seelig, Anna
Georg, Gunda I.
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Abstract
7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7-deoxypaclitaxel were prepared and evaluated for their ability
to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with Pglycoprotein
in bovine brain microvessel endothelial cells. The three compounds were essentially equivalent to paclitaxel in cytotoxicity
against NCI/ADR-RES cells. They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy
compounds having less interaction than paclitaxel and 7-deoxypaclitaxel. ©2000 Elsevier Science Ltd. All rights reserved.
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Please note that this is an author-produced PDF of an article accepted for publication following peer review. The publisher version is available on its site.
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2006
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Elsevier
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Ge, H., Vasandani, V., Huff, J.K., Audus, K.L., Himes, R.H., Seelig, A., and Georg, G.I. (2006) Synthesis and interactions of 7-deoxy-, 10-deacetoxy and 7,10-dideoxypaclitaxel with MCF7-ADR cancer cells and bovine brain microvessel endothelial cells. Bioorg. Med. Chem. Lett., 16, 433-436. PMID: 16271474 http://dx.doi.org/10.1016/j.bmcl.2005.09.043