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Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy
Hasan, Anwarul Waters, Renae Roula, Boustany Dana, Rahbani Yara, Seif Alexandre, Toubia Paul, Arghya
Hasan, Anwarul
Waters, Renae
Roula, Boustany
Dana, Rahbani
Yara, Seif
Alexandre, Toubia
Paul, Arghya
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Abstract
Cardiovascular disease is a leading cause of death worldwide. Since adult cardiac cells are limited in their proliferation, cardiac tissue with dead or damaged cardiac cells downstream of the occluded vessel does not regenerate after myocardial infarction. The cardiac tissue is then replaced with nonfunctional fibrotic scar tissue rather than new cardiac cells, which leaves the heart weak. The limited proliferation ability of host cardiac cells has motivated investigators to research the potential cardiac regenerative ability of stem cells. Considerable progress has been made in this endeavor. However, the optimum type of stem cells along with the most suitable matrix-material and cellular microenvironmental cues are yet to be identified or agreed upon. This review presents an overview of various types of biofunctional materials and biomaterial matrices, which in combination with stem cells, have shown promises for cardiac tissue replacement and reinforcement. Engineered biomaterials also have applications in cardiac tissue engineering, in which tissue constructs are developed in vitro by combining stem cells and biomaterial scaffolds for drug screening or eventual implantation. This review highlights the benefits of using biomaterials in conjunction with stem cells to repair damaged myocardium and give a brief description of the properties of these biomaterials that make them such valuable tools to the field.
Description
This is the peer reviewed version of the following article: Hasan, A., Waters, R., Roula, B., Dana, R., Yara, S., Alexandre, T. and Paul, A. (2016), Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy. Macromol. Biosci., 16: 958–977. doi:10.1002/mabi.201500396, which has been published in final form at http://doi.org/10.1002/mabi.201500396. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Date
2016-03-08
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Wiley
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Keywords
Angiogenesis, Hydrogel, Myocardial infarction, Nanomedicine, Stem cells
Citation
Hasan, A., Waters, R., Roula, B., Dana, R., Yara, S., Alexandre, T. and Paul, A. (2016), Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy. Macromol. Biosci., 16: 958–977. doi:10.1002/mabi.201500396