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Hospitalization at the end of life in patients with multiple myeloma
Abbasi, Saqib ; Roller, John ; Abdallah, Al-Ola ; Shune, Leyla ; McClune, Brian ; Sborov, Douglas ; Mohyuddin, Ghulam Rehman
Abbasi, Saqib
Roller, John
Abdallah, Al-Ola
Shune, Leyla
McClune, Brian
Sborov, Douglas
Mohyuddin, Ghulam Rehman
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Abstract
Background
Despite advances in treatment, multiple myeloma (MM) remains incurable and results in significant morbidity and mortality. Further research investigating where MM patients die and characterization of end-of-life hospitalizations is needed.
Methods
We utilized the National Inpatient Sample (NIS) to explore the hospitalization burden of MM patients at the end of their lives.
Results
The percent of patients dying in the hospital as a percent of overall MM deaths ranged from 54% in 2002 to 41.4% in 2017 (pā<ā0.01). Blood transfusions were received in 32.7% of these hospitalizations and infections were present in 47.8% of patients. Palliative care and/or hospice consultations ranged from 5.3% in 2002 to 31.4% in 2017 (pā<ā0.01).
Conclusion
Our study demonstrates that patients with MM dying in the hospital have a significant requirement for blood transfusions and have a high infection burden. We also show that palliative care and hospice involvement at the end of life has increased over time but remains low, and that ultimately, inpatient mortality has decreased over time, but MM patients die in the hospital at a higher rate than the general population.
Description
A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author's publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml.
Date
2021-03-31
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BMC
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Keywords
Multiple myeloma, Palliative care, Hospice, Death, National inpatient sample, Inpatient, Hospital
Citation
Abbasi, S., Roller, J., Abdallah, AO. et al. Hospitalization at the end of life in patients with multiple myeloma. BMC Cancer 21, 339 (2021). https://doi.org/10.1186/s12885-021-08079-x