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Estrogen signaling impacts temporomandibular joint and periodontal disease pathology
Robinson, Jennifer L. Johnson, Pamela M. Kister, Karolina Yin, Michael T. Chen, Jing Wadhwa, Sunil
Robinson, Jennifer L.
Johnson, Pamela M.
Kister, Karolina
Yin, Michael T.
Chen, Jing
Wadhwa, Sunil
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Abstract
Women experience a higher incidence of oral diseases including periodontal diseases and temporomandibular joint disease (TMD) implicating the role of estrogen signaling in disease pathology. Fluctuating levels of estrogen during childbearing age potentiates facial pain, high estrogen levels during pregnancy promote gingivitis, and low levels of estrogen during menopause predisposes the TMJ to degeneration and increases alveolar bone loss. In this review, an overview of estrogen signaling pathways in vitro and in vivo that regulate pregnancy-related gingivitis, TMJ homeostasis, and alveolar bone remodeling is provided. Deciphering the specific estrogen signaling pathways for individual oral diseases is crucial for potential new drug therapies to promote and maintain healthy tissue.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Date
2020-04-30
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Publisher
Springer Verlag
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Keywords
Estrogen, Temporomandibular joint, Periodontal disease, Alveolar bone, Oral health, Women’s health
Citation
Robinson, J. L., Johnson, P. M., Kister, K., Yin, M. T., Chen, J., & Wadhwa, S. (2020). Estrogen signaling impacts temporomandibular joint and periodontal disease pathology. Odontology, 108(2), 153–165. https://doi.org/10.1007/s10266-019-00439-1