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A Nitro Enolate Approach to the Synthesis of 4, 5-Disubstituted-2-Aminoimidazoles. Pilot Library Assembly and Screening for Antibiotic and Antibiofilm Activity
Zhaoming, Su Rogers, Steven A. McCall, W. Steve Smith, Alicia C. Ravishankar, Sindhu Mullikin, Trey Melander, Christian
Zhaoming, Su
Rogers, Steven A.
McCall, W. Steve
Smith, Alicia C.
Ravishankar, Sindhu
Mullikin, Trey
Melander, Christian
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Abstract
A library of 4,5-disubstituted-2-aminoimidazoles was synthesized using a nitroenolate route and then screened for antibiofilm and antimicrobial activity. These compounds displayed notable biofilm dispersal and planktonic microbicidal activity against various Gram-positive and Gram-negative bacteria.
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This is the published version. Copyright Royal Society of Chemistry
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2010-04-29
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Royal Society of Chemistry
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Su, Zhaoming, Steven A. Rogers, W. Steve Mccall, Alicia C. Smith, Sindhu Ravishankar, Trey Mullikin, and Christian Melander. "A Nitroenolate Approach to the Synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot Library Assembly and Screening for Antibiotic and Antibiofilm Activity." Organic & Biomolecular Chemistry Org. Biomol. Chem. 8.12 (2010): 2814. DOI:10.1039/C001479F