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Limited Evidence for Parallel Evolution Among Desert-Adapted Peromyscus Deer Mice

Colella, Jocelyn P.
Tigano, Anna
Dudchenko, Olga
Omer, Arina D.
Khan, Ruqayya
Bochkov, Ivan D.
Aiden, Erez L.
MacManes, Matthew D.
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Abstract
Warming climate and increasing desertification urge the identification of genes involved in heat and dehydration tolerance to better inform and target biodiversity conservation efforts. Comparisons among extant desert-adapted species can highlight parallel or convergent patterns of genome evolution through the identification of shared signatures of selection. We generate a chromosome-level genome assembly for the canyon mouse (Peromyscus crinitus) and test for a signature of parallel evolution by comparing signatures of selective sweeps across population-level genomic resequencing data from another congeneric desert specialist (Peromyscus eremicus) and a widely distributed habitat generalist (Peromyscus maniculatus), that may be locally adapted to arid conditions. We identify few shared candidate loci involved in desert adaptation and do not find support for a shared pattern of parallel evolution. Instead, we hypothesize divergent molecular mechanisms of desert adaptation among deer mice, potentially tied to species-specific historical demography, which may limit or enhance adaptation. We identify a number of candidate loci experiencing selective sweeps in the P. crinitus genome that are implicated in osmoregulation (Trypsin, Prostasin) and metabolic tuning (Kallikrein, eIF2-alpha kinase GCN2, APPL1/2), which may be important for accommodating hot and dry environmental conditions.
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Date
2021-03-04
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Oxford University Press
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Keywords
Dehydration, Desert, Parallel evolution, Peromyscus, Thermoregulation
Citation
Jocelyn P Colella, Anna Tigano, Olga Dudchenko, Arina D Omer, Ruqayya Khan, Ivan D Bochkov, Erez L Aiden, Matthew D MacManes, Limited Evidence for Parallel Evolution Among Desert-Adapted Peromyscus Deer Mice, Journal of Heredity, Volume 112, Issue 3, May 2021, Pages 286–302, https://doi.org/10.1093/jhered/esab009
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