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Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates
Weidenbacher, Payton A.-B. Sanyal, Mrinmoy Friedland, Natalia Tang, Shaogeng Arunachalam, Prabhu S. Hu, Mengyun Kumru, Ozan S. Kate Morris, Mary Fontenot, Jane Shirreff, Lisa
Weidenbacher, Payton A.-B.
Sanyal, Mrinmoy
Friedland, Natalia
Tang, Shaogeng
Arunachalam, Prabhu S.
Hu, Mengyun
Kumru, Ozan S.
Kate Morris, Mary
Fontenot, Jane
Shirreff, Lisa
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Abstract
While the rapid development of COVID-19 vaccines has been a scientific triumph, the need remains for a globally available vaccine that provides longer-lasting immunity against present and future SARS-CoV-2 variants of concern (VOCs). Here, we describe DCFHP, a ferritin-based, protein-nanoparticle vaccine candidate that, when formulated with aluminum hydroxide as the sole adjuvant (DCFHP-alum), elicits potent and durable neutralizing antisera in non-human primates against known VOCs, including Omicron BQ.1, as well as against SARS-CoV-1. Following a booster ~one year after the initial immunization, DCFHP-alum elicits a robust anamnestic response. To enable global accessibility, we generated a cell line that can enable production of thousands of vaccine doses per liter of cell culture and show that DCFHP-alum maintains potency for at least 14 days at temperatures exceeding standard room temperature. DCFHP-alum has potential as a once-yearly (or less frequent) booster vaccine, and as a primary vaccine for pediatric use including in infants.
Description
Date
2023-10-05
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Publisher
Nature Research
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Keywords
Protein vaccines, SARS-CoV-2, Antibodies
Citation
Weidenbacher PA, Sanyal M, Friedland N, Tang S, Arunachalam PS, Hu M, Kumru OS, Morris MK, Fontenot J, Shirreff L, Do J, Cheng YC, Vasudevan G, Feinberg MB, Villinger FJ, Hanson C, Joshi SB, Volkin DB, Pulendran B, Kim PS. Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. Nat Commun. 2023 Oct 5;14(1):6211. doi: 10.1038/s41467-023-42061-4. Erratum for: Nat Commun. 2023 Apr 17;14(1):2149. doi: 10.1038/s41467-023-37417-9. PMID: 37798288; PMCID: PMC10556009