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Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain
Clarke, Duncan J. Azuma, Yoshiaki
Clarke, Duncan J.
Azuma, Yoshiaki
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Abstract
DNA Topoisomerase II (Topo II ) is a ubiquitous enzyme in eukaryotes that performs
the strand passage reaction where a double helix of DNA is passed through a second double
helix. This unique reaction is critical for numerous cellular processes. However, the enzyme also
possesses a C-terminal domain (CTD) that is largely dispensable for the strand passage reaction
but is nevertheless important for the fidelity of cell division. Recent studies have expanded our
understanding of the roles of the Topo II CTD, in particular in mitotic mechanisms where the CTD
is modified by Small Ubiquitin-like Modifier (SUMO), which in turn provides binding sites for key
regulators of mitosis.
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Date
2017
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Publisher
MDPI
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Keywords
Topoisomerase II, SUMO, C-terminal domain, Mitosis, Aurora B, Haspin, Claspin, Metaphase checkpoint
Citation
Clarke DJ, Azuma Y. Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain. International Journal of Molecular Sciences. 2017; 18(11):2438