Loading...
Revisiting the Plasmodium falciparum RIFIN family: from comparative genomics to 3D-model prediction.
Bultrini, Emanuele Mukherjee, Srayanta Zhang, Yang Silvestrini, Francesco Alano, Pietro Pizzi, Elisabetta
Bultrini, Emanuele
Mukherjee, Srayanta
Zhang, Yang
Silvestrini, Francesco
Alano, Pietro
Pizzi, Elisabetta
Citations
Altmetric:
Abstract
Subtelomeric RIFIN genes constitute the most abundant multigene family in
Plasmodium falciparum. RIFIN products are targets for the human immune response and contribute
to the antigenic variability of the parasite. They are transmembrane proteins grouped into two subfamilies
(RIF_A and RIF_B). Although recent data show that RIF_A and RIF_B have different subcellular
localisations and possibly different functions, the same structural organisation has been
proposed for members of the two sub-families. Despite recent advances, our knowledge of the
regulation of RIFIN gene expression is still poor and the biological role of the protein products
remain obscure.
Description
Date
2009-09-21
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
Bultrini, Emanuele, Kevin Brick, Srayanta Mukherjee, Yang Zhang, Francesco Silvestrini, Pietro Alano, and Elisabetta Pizzi. 2009. “Revisiting the Plasmodium Falciparum RIFIN Family: From Comparative Genomics to 3D-Model Prediction.” BMC Genomics 10: 445. http://dx.doi.org/10.1186/1471-2164-10-445