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Regioselective C5-alkylation and C5-methylcarbamate formation of 2,3-dihydro-4-pyridones and C3-alkylation and C3-methylcarbamate formation of 4-(pyrrolidin-1-yl)furan-2(5H)-one
Gu, Xingxian Georg, Gunda I.
Gu, Xingxian
Georg, Gunda I.
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Abstract
Reactions of N-alkyl-2,3-dihydro-4-pyridones and 4-(pyrrolidin-1-yl)furan-2(5H)-one with aldehydes and triethylsilane in a one-flask procedure provided C5 and C3 alkylated derivatives, respectively. Mannich-type reactions with formaldehyde and carbamates in the presence of lithium perchlorate furnished C5/C3 methylcarbamates.
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Date
2015-10-21
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Elsevier
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Keywords
2, 3-dihydro-4pyridones, 4-(pyrrolidin-1-yl) furan-2(5H)-one, Regioselective alkylation, Mannich reaction
Citation
Gu, Xingxian, and Gunda I. Georg. “Regioselective C5-Alkylation and C5-Methylcarbamate Formation of 2,3-Dihydro-4-Pyridones and C3-Alkylation and C3-Methylcarbamate Formation of 4-(pyrrolidin-1-Yl)furan-2(5H)-One.” Tetrahedron letters 56.43 (2015): 5874–5877.