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Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

Rogers, Steven A.
; 
Huigens, Robert W., III
; 
Cavanagh, John
; 
Melander, Christian
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Abstract
2-Aminoimidazoles are an emerging class of small molecules that possess the ability to inhibit and disperse biofilms across bacterial order, class, and phylum. Herein, we report the synergistic effect between a 2-aminoimidazole/triazole conjugate and antibiotics toward dispersing preestablished biofilms, culminating with a 3-orders-of-magnitude increase of biofilm dispersion toward Staphylococcus aureus biofilms. Furthermore, we document that the 2-aminoimidazole/triazole conjugate will also resensitize multidrug-resistant strains of bacteria to the effects of conventional antibiotics, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Acinetobacter baumannii.
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This is the published version.
Date
2010-05
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American Society for Microbiology
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Pharmacy Scholarly Works
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Rogers, S. A., R. W. Huigens, J. Cavanagh, and C. Melander. "Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents." Antimicrobial Agents and Chemotherapy 54.5 (2010): 2112-118. http://dx.doi.org/10.1128/AAC.01418-09
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https://hdl.handle.net/1808/19372
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