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γ-Tubulin complexes in microtubule nucleation and beyond
Oakley, Berl R. Paolillo, Vitoria Zheng, Yixian
Oakley, Berl R.
Paolillo, Vitoria
Zheng, Yixian
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Abstract
Tremendous progress has been made in understanding the functions of γ-tubulin and, in particular, its role in microtubule nucleation since the publication of its discovery in 1989. The structure of γ-tubulin has been determined, and the components of γ-tubulin complexes have been identified. Significant progress in understanding the structure of the γ-tubulin ring complex and its components has led to a persuasive model for how these complexes nucleate microtubule assembly. At the same time, data have accumulated that γ-tubulin has important but less well understood functions that are not simply a consequence of its function in microtubule nucleation. These include roles in the regulation of plus-end microtubule dynamics, gene regulation, and mitotic and cell cycle regulation. Finally, evidence is emerging that γ-tubulin mutations or alterations of γ-tubulin expression play an important role in certain types of cancer and in other diseases.
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2015-07-02
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The American Society For Cell Biology
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Oakley, B. R., Paolillo, V., & Zheng, Y. (2015). y-Tubulin complexes in microtubule nucleation and beyond. Molecular Biology of the Cell, 26(17), 2957–2962. doi:10.1091/mbc.e14-11-1514