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Recent advances in computational studies of GPCR-G protein interactions
Wang, Jinan Miao, Yinglong
Wang, Jinan
Miao, Yinglong
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Abstract
Protein-protein interactions are key in cellular signaling. G protein-coupled receptors (GPCRs), the largest superfamily of human membrane proteins, are able to transduce extracellular signals (e.g., hormones and neurotransmitters) to intracellular proteins, in particular the G proteins. Since GPCRs serve as primary targets of ~ 1/3 of currently marketed drugs, it is important to understand mechanisms of GPCR signaling in order to design selective and potent drug molecules. This chapter focuses on recent advances in computational studies of the GPCR-G protein interactions using bioinformatics, protein-protein docking and molecular dynamics simulation approaches.
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Date
2019-01-03
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Elsevier
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Keywords
Protein-protein interactions, GPCR-G protein interactions, Bioinformatics, Protein-protein docking, Molecular dynamics
Citation
Wang, J., & Miao, Y. (2019). Recent advances in computational studies of GPCR-G protein interactions. Advances in protein chemistry and structural biology, 116, 397–419. https://doi.org/10.1016/bs.apcsb.2018.11.011