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The Role of the PD-1 Immunoreceptor in Pregnancy
Taglauer, Elizabeth Susan
Taglauer, Elizabeth Susan
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Abstract
During pregnancy, the maternal immune system must be carefully modulated as the fetus is immunologically foreign to her leukocytes. We propose that the CD28 family immune receptor, PD-1, functions during pregnancy to control maternal immune reactions. PD-1 is expressed on T lymphocytes and following interaction with its ligand, B7-H1, prevents T cell activation. B7-H1 is expressed in the human placenta throughout gestation, therefore we studied the role of the PD-1 receptor in modulating maternal T cells during pregnancy. PD-1 is preferentially expressed on human decidual T cells and B7-H1 inhibits the inflammatory cytokine production of activated decidual T lymphocytes. In addition, possibly through B7-H1:PD-1 interactions, trophoblasts induce regulatory T cell expansion in vitro. Finally, in murine pregnancy, PD-1 controls the accumulation of paternal antigen-specific T cells in the uterus-draining lymph nodes. Overall, these studies suggest that the PD-1:B7-H1 pathway functions to help maintain maternal-fetal tolerance.
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Date
2008-08-08
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Publisher
University of Kansas
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Keywords
Cell biology, Pregnancy, Immunology, Reproduction, T cells, Pd-1, B7-h1