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In vivo photoacoustic imaging of breast cancer tumor with HER2-targeted nanodiamonds
Zhang, Ti Cui, Huizhong Fang, Chia-Yi Jo, Janggun Yang, Xinmai Chang, Huan-Cheng Forrest, M. Laird
Zhang, Ti
Cui, Huizhong
Fang, Chia-Yi
Jo, Janggun
Yang, Xinmai
Chang, Huan-Cheng
Forrest, M. Laird
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Abstract
Radiation-damaged nanodiamonds (NDs) are ideal optical contrast agents for photoacoustic (PA) imaging in biological tissues due to their good biocompatibility and high optical absorbance in the near-infrared (NIR) range. Acid treated NDs are oxidized to form carboxyl groups on the surface, functionalized with polyethylene glycol (PEG) and human epidermal growth factor receptor 2 (HER2) targeting ligand for breast cancer tumor imaging. Because of the specific binding of the ligand conjugated NDs to the HER2-overexpressing murine breast cancer cells (4T1.2 neu), the tumor tissues are significantly delineated from the surrounding normal tissue at wavelength of 820 nm under the PA imaging modality. Moreover, HER2 targeted NDs (HER2-PEG-NDs) result in higher accumulation in HER2 positive breast tumors as compared to non-targeted NDs after intravenous injection (i.v.). Longer retention time of HER-PEG-NDs is observed in HER2 overexpressing tumor model than that in negative tumor model (4T1.2). This demonstrates that targeting moiety conjugated NDs have great potential for the sensitive detection of cancer tumors and provide an attractive delivery strategy for anti-cancer drugs.
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Date
2013-09-20
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Society of Photo-optical Instrumentation Engineers
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cui_photoacoustic.pdf
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Keywords
Nanodiamond, Photoacoustic imaging, Breast cancer, HER2
Citation
Zhang, Ti, Huizhong Cui, Chia-Yi Fang, Janggun Jo, Xinmai Yang, Huan-Cheng Chang, and M. Laird Forrest. "In Vivo Photoacoustic Imaging of Breast Cancer Tumor with HER2-targeted Nanodiamonds." Nanoimaging and Nanospectroscopy (2013): n. pag.