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CT-based lung motion differences in patients with usual interstitial pneumonia and nonspecific interstitial pneumonia
Choi, Jiwoong Chae, Kum Ju Jin, Gong Yong Lin, Ching-Long Laroia, Archana T. Hoffman, Eric A. Lee, Chang Hyun
Choi, Jiwoong
Chae, Kum Ju
Jin, Gong Yong
Lin, Ching-Long
Laroia, Archana T.
Hoffman, Eric A.
Lee, Chang Hyun
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Abstract
We applied quantitative CT image matching to assess the degree of motion in the idiopathic ILD such as usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). Twenty-one normal subjects and 42 idiopathic ILD (31 UIP and 11 NSIP) patients were retrospectively included. Inspiratory and expiratory CT images, reviewed by two experienced radiologists, were used to compute displacement vectors at local lung regions matched by image registration. Normalized three-dimensional and two-dimensional (dorsal-basal) displacements were computed at a sub-acinar scale. Displacements, volume changes, and tissue fractions in the whole lung and the lobes were compared between normal, UIP, and NSIP subjects. The dorsal-basal displacement in lower lobes was smaller in UIP patients than in NSIP or normal subjects (p = 0.03, p = 0.04). UIP and NSIP were not differentiated by volume changes in the whole lung or upper and lower lobes (p = 0.53, p = 0.12, p = 0.97), whereas the lower lobe air volume change was smaller in both UIP and NSIP than normal subjects (p = 0.02, p = 0.001). Regional expiratory tissue fractions and displacements showed positive correlations in normal and UIP subjects but not in NSIP subjects. In summary, lung motionography quantified by image registration-based lower lobe dorsal-basal displacement may be used to assess the degree of motion, reflecting limited motion due to fibrosis in the ILD such as UIP and NSIP.
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Date
2022-10-04
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Frontiers Media
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Keywords
Interstitial lung disease, Idiopathic pulmonary fibrosis, Usual interstitial pneumonia, Computed tomography, Lung motionography, Quantitative computed tomography image matching, Image registration, Computational biomechanics
Citation
Choi J, Chae KJ, Jin GY, Lin C-L, Laroia AT, Hoffman EA and Lee CH (2022) CT-based lung motion differences in patients with usual interstitial pneumonia and nonspecific interstitial pneumonia. Front. Physiol. 13:867473. doi: 10.3389/fphys.2022.867473