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Receptor-mediated angiotensin II transcytosis by brain mcrovessel endothelial cells

Rose, Jayna M.
Audus, Kenneth L.
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Abstract
ROSE, J. M. AND K. L. AUDUS. Receptor-mediated angiotensin II transcytosis by brain microvessel endothelial cells. PEPTIDES __( ) _____, 199_. - Angiotensin II (Ang II) uptake and transport across monolayers of bovine brain microvessel endothelial cells (BMECs) was demonstrated. Ang II transport was linear up to 2 hours, saturable with a Km of 1.7 nM, and tended to be polarized with the apical-to-basolateral transport being greater. [3H]-Ang II transport was found to be inhibited by excess unlabeled Ang II, by the Ang II analog sarathrin, and by the endocytic inhibitor phenylarsine oxide. Ang II-(2-8) and -(3-8) were shown to significantly increase the transport of Ang II. These results demonstrate for the first time the receptor-mediated transcytosis of Ang II across brain microvessel endothelium.
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Date
1998
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Publisher
Elsevier
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Keywords
Angiotensin II transcytosis, Cerebral endothelium, Blood-brain barrier, Brain microvessel endothelial cells
Citation
Rose, J.M. and Audus, K.L. (1998) Receptor-mediated angiotensin II transcytosis by brain mcrovessel endothelial cells. Peptides 19, 1023-1030. PMID: 9700750 http://dx.doi.org/10.1016/S0196-9781(98)00054-0
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