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HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in mice
Wang, Hong Davido, David J. Morrison, Lynda A.
Wang, Hong
Davido, David J.
Morrison, Lynda A.
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Abstract
Strains of HSV-1 have been noted to vary in their pathogenesis. We compared the replication of strains KOS and McKrae in mice by two routes of infection, ocular and vaginal. Peripheral replication of KOS was similar (cornea) or attenuated over time (vagina) compared with McKrae; however, McKrae replicated in the nervous system to significantly higher levels than KOS after inoculation by either route. Host genetic background strongly influenced the capacity for virus entry into the nervous system from the vagina. KOS and McKrae replicated equivalently after intracranial inoculation, indicating that McKrae’s pathogenic phenotype is linked to neuroinvasiveness rather than neurovirulence.
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Date
2013-01-20
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Elsevier
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Keywords
Herpes simplex virus, Pathogenesis, Cornea, Vagina, Central nervous system, Mice
Citation
Wang, Hong, David J. Davido, and Lynda A. Morrison. “HSV-1 Strain McKrae Is More Neuroinvasive than HSV-1 KOS after Corneal or Vaginal Inoculation in Mice.” Virus research 173.2 (2013): 436–440.