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Synthetic Studies to Lyngbouilloside: A Phosphate Tether-Mediated Synthesis of the Macrolactone Core
Chegondi, Rambabu ; Hanson, Paul R.
Chegondi, Rambabu
Hanson, Paul R.
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Abstract
A concise synthetic pathway to the originally assigned structure of lyngbouilloside macrolactone (3) is reported. The core macrocycle 3 was synthesized via a phosphate tether-mediated, one-pot, sequential RCM/CM/chemoselective hydrogenation reaction, Roskamp homologation, and a high yielding Boeckman acylketene cyclization.
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Date
2015-06-03
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Publisher
Elsevier
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Keywords
Phosphate tether, (-)-Lyngbouilloside, Total synthesis, Metathesis
Citation
Chegondi, Rambabu, and Paul R. Hanson. “Synthetic Studies to Lyngbouilloside: A Phosphate Tether-Mediated Synthesis of the Macrolactone Core.” Tetrahedron letters 56.23 (2015): 3330–3333.