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Synthesis and Biological Evaluation of Coumarin Replacements of Novobiocin as Hsp90 Inhibitors
Kusuma, Bhaskar Reddy Khandelwal, Anuj Gu, Wen Brown, Douglas Liu, Weiya Vielhauer, George A. Holzbeierlein, Jeffery M. Blagg, Brian S. J.
Kusuma, Bhaskar Reddy
Khandelwal, Anuj
Gu, Wen
Brown, Douglas
Liu, Weiya
Vielhauer, George A.
Holzbeierlein, Jeffery M.
Blagg, Brian S. J.
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Abstract
Since Hsp90 modulates all six hallmarks of cancer simultaneously, it has become an attractive target for the development of cancer chemotherapeutics. In an effort to develop more efficacious compounds for Hsp90 inhibition, novobiocin analogues were prepared by replacing the central coumarin core with naphthalene, quinolinone, and quinoline surrogates. These modifications allowed for modification of the 2-position, which was previously unexplored. Biological evaluation of these compounds suggests a hydrophobic pocket about the 2-position of novobiocin. Anti-proliferative activities of these analogues against multiple cancer cell lines identified 2-alkoxyquinoline derivatives to exhibit improved activity.
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2014-02-15
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Elsevier
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Kusuma, B. R., Khandelwal, A., Gu, W., Brown, D., Liu, W., Vielhauer, G., … Blagg, B. S. J. (2014). Synthesis and Biological Evaluation of Coumarin Replacements of Novobiocin as Hsp90 Inhibitors. Bioorganic & Medicinal Chemistry, 22(4), 1441–1449. http://doi.org/10.1016/j.bmc.2013.12.056