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Breaking a pathogen’s iron will: inhibiting siderophore production as an antimicrobial strategy
Lamb, Audrey L.
Lamb, Audrey L.
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Abstract
The rise of antibiotic resistance is a growing public health crisis. Novel antimicrobials are sought, preferably developing nontraditional chemical scaffolds that do not inhibit standard targets such as cell wall synthesis or the ribosome. Iron scavenging has been proposed as a viable target, because bacterial and fungal pathogens must overcome the nutritional immunity of the host to be virulent. This review highlights the recent work toward exploiting the biosynthetic enzymes of siderophore production for the design of next generation antimicrobials.
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Date
2015-05-10
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Elsevier
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Keywords
Siderophore, Nonribosomal peptide synthetase, Polyketide synthase, NRPS-independent synthetase
Citation
Lamb, Audrey L. "Breaking a Pathogen's Iron Will: Inhibiting Siderophore Production as an Antimicrobial Strategy." Biochimica Et Biophysica Acta (BBA) - Proteins and Proteomics 1854.8 (2015): 1054-070. Web.