Loading...
Microwave-assisted sequential one-pot protocol to benzothiadiazin-3-one-1,1-dioxides via a copper-catalyzed N-arylation strategy
Rolfe, Alan Hanson, Paul R.
Rolfe, Alan
Hanson, Paul R.
Citations
Altmetric:
Abstract
A microwave-assisted, sequential, one-pot protocol has been developed for the synthesis of a variety of benzothiadiazin-3-one-1,1-dioxides. This protocol utilizes a copper-catalyzed N-arylation of α-bromo-benzenesulfonamides with a number of amines to generate the corresponding 2-aminobenzenesulfonamides, which undergo cyclization to the desired sultams using carbonyl diimidazole (CDI). A range of conditions was evaluated for the key C–N bond formation step with tolerance toward functionalized amines.
Description
Date
2009-12-16
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
Rolfe, Alan, and Paul R. Hanson. “Microwave-Assisted Sequential One-Pot Protocol to Benzothiadiazin-3-One-1,1-Dioxides via a Copper-Catalyzed N-Arylation Strategy.” Tetrahedron letters 50.50 (2009): 6935–6937.