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Integration of photoacoustic imaging and high-intensity focused ultrasound
Cui, Huizhong Staley, Jacob W. Yang, Xinmai
Cui, Huizhong
Staley, Jacob W.
Yang, Xinmai
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Abstract
We have developed an integrated photoacoustic imaging (PAI) and high-intensity focused ultrasound (HIFU) system for solid
tumor treatments. A single-element, spherically focused ultrasonic transducer, with a central frequency of 5 MHz, was used to induce HIFU lesions in soft tissue. The same ultrasonic transducer was also used as a detector during PAI to guide HIFU ablation. The use of same transducer for PAI and HIFU can reduce the requirement on acoustic windows during the imaging guided therapy, as well as ensuring the correct alignment between the therapeutic beam and the planned treatment volume. During an experiment, targeted soft tissue was first imaged by PAI. The resulted image was used to plan the subsequent HIFU ablation. After the HIFU ablation, targeted soft tissue was imaged again by PAI to evaluate the effectiveness of treatments. Good contrast was obtained between photoacoustic images before and after HIFU ablation. In conclusion, our results demonstrated that PAI technology may potentially be integrated with HIFU ablation for image-guided therapy.
Description
This is the published version.
Date
2010-03-23
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Publisher
Society of Photo-optical Instrumentation Engineers
Research Projects
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Keywords
High-intensity focused ultrasound (HIFU), Photoacoustic imaging (PAI), Image-guided therapy
Citation
Cui, Huizhong, Jacob Staley, and Xinmai Yang. "Integration of Photoacoustic Imaging and High-intensity Focused Ultrasound." J. Biomed. Opt. Journal of Biomedical Optics 15.2 (2010): 021312. http://dx.doi.org/10.1117/1.3365948.