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Preferential adhesion maintains separation of ommatidia in the Drosophila eye
Bao, Sujin Fischbach, Karl-Friedrich Corbin, Victoria Cagan, Ross L.
Bao, Sujin
Fischbach, Karl-Friedrich
Corbin, Victoria
Cagan, Ross L.
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Abstract
In the Drosophila eye, neighboring ommatidia are separated by inter-ommatidial cells (IOCs). How this ommatidial spacing emerges during eye development is not clear. Here we demonstrate that four adhesion molecules of the Irre cell recognition module (IRM) family play a redundant role in maintaining separation of ommatidia. The four IRM proteins are divided into two groups: Kirre and Rst are expressed in IOCs, and Hbs and Sns in primary pigment cells (1°s). Kirre binds Hbs and Sns in vivo and in vitro. Reducing activity of either Rst or Kirre alone had minimal effects on ommatidial spacing, but reducing both together led to direct ommatidium:ommatidium contact. A similar phenotype was also observed when reducing both Hbs and Sns. Consistent with the role of these factors in sorting ommatidia, mis-expression of Hbs plus Sns within a single IOC led to complete separation of the cell from neighboring ommatidia. Our results indicate mutual preferential adhesion between ommatidia and IOCs mediated by four IRM proteins is both necessary and sufficient to maintain separation of ommatidia.
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Date
2011-08-15
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Elsevier
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Keywords
Cell adhesion, Preferential adhesion, Drosophila, Eye, Pattern formation
Citation
Bao, Sujin, Karl-Friedrich Fischbach, Victoria Corbin, and Ross L. Cagan. "Preferential Adhesion Maintains Separation of Ommatidia in the Drosophila Eye." Developmental Biology 344.2 (2010): 948-56.