gene_ID Med.mean RP.mean NRP.mean PPDE Pattern Blast.hit GO_ID HMM.fam comp288703_c0 21.5682057449 0.0 0.0 1.0 MED_UP achain catalytic and ubiqutin-associated domains of mark2par-1: wild type P:neuron migration; P:intracellular protein kinase cascade; F:protein binding; P:Wnt receptor signaling pathway; P:regulation of cytoskeleton organization; P:establishment or maintenance of epithelial cell apical/basal polarity; P:protein autophosphorylation; C:basal cortex; F:protein serine/threonine kinase activity; F:magnesium ion binding; F:lipid binding; P:establishment of cell polarity; P:positive regulation of neuron projection development; C:plasma membrane; C:nucleus; F:ATP binding; F:tau-protein kinase activity; P:response to oxidative stress; P:regulation of axonogenesis Pkinase Protein kinase domain comp86393_c0 58.7283677201 0.0 0.0 1.0 MED_UP casein kinase i isoform gamma-3 isoform 6 C:cytoplasm; P:Wnt receptor signaling pathway; P:protein phosphorylation; F:ATP binding; F:protein serine/threonine kinase activity Pfam-B_584 comp86393_c1 19.1777285346 0.0 0.0 1.0 MED_UP casein kinase i isoform gamma-3 isoform 7 C:cytoplasm; P:Wnt receptor signaling pathway; P:protein phosphorylation; F:ATP binding; F:protein serine/threonine kinase activity Pkinase Protein kinase domain comp113746_c0 0.0 8.49603776037 36.0349563068 0.999999999824 NRP_UP fibroblast growth factor receptor 2-like, fibroblast growth factor receptor b precursor P:epidermal growth factor receptor signaling pathway; P:prostate epithelial cord elongation; P:Fc-epsilon receptor signaling pathway; P:midbrain development; P:lateral sprouting from an epithelium; P:protein autophosphorylation; P:fibroblast growth factor receptor signaling pathway involved in hemopoiesis; P:regulation of fibroblast growth factor receptor signaling pathway; P:axonogenesis; P:ureteric bud development; P:positive regulation of cell division; P:regulation of cell fate commitment; P:positive regulation of mesenchymal cell proliferation; P:lacrimal gland development; F:fibroblast growth factor binding; P:branching involved in labyrinthine layer morphogenesis; P:bud elongation involved in lung branching; P:pyramidal neuron development; P:fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; F:protein homodimerization activity; P:innate immune response; P:embryonic cranial skeleton morphogenesis; P:angiogenesis; P:bone mineralization; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification; P:mesenchymal cell differentiation involved in lung development; P:limb bud formation; C:cell cortex; F:fibroblast growth factor-activated receptor activity; P:positive regulation of cardiac muscle cell proliferation; P:outflow tract septum morphogenesis; P:mammary gland bud formation; P:epithelial cell proliferation involved in salivary gland morphogenesis; P:branching morphogenesis of a nerve; P:positive regulation of transcription from RNA polymerase II promoter; C:excitatory synapse; P:ventricular zone neuroblast division; C:cell surface; P:neurotrophin TRK receptor signaling pathway; P:embryonic pattern specification; P:cell-cell signaling; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; P:fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; P:positive regulation of phospholipase activity; C:nucleus; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; P:regulation of smoothened signaling pathway; P:positive regulation of cell cycle; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; P:lung lobe morphogenesis; P:branch elongation involved in salivary gland morphogenesis; P:ventricular cardiac muscle tissue morphogenesis; P:regulation of multicellular organism growth; P:phosphatidylinositol-mediated signaling; P:post-embryonic development; P:lung alveolus development; P:peptidyl-tyrosine phosphorylation; P:bone morphogenesis; P:regulation of osteoblast differentiation; P:odontogenesis; F:nucleotide binding; P:negative regulation of transcription from RNA polymerase II promoter; P:positive regulation of canonical Wnt receptor signaling pathway; P:lung-associated mesenchyme development; P:otic vesicle formation; P:regulation of osteoblast proliferation; P:regulation of branching involved in prostate gland morphogenesis; P:positive regulation of ERK1 and ERK2 cascade; F:anion binding; C:extracellular matrix; P:membranous septum morphogenesis; P:hair follicle morphogenesis; P:regulation of smooth muscle cell differentiation; P:embryonic digestive tract morphogenesis; P:insulin receptor signaling pathway; P:mesenchymal cell proliferation involved in lung development; C:integral to plasma membrane Pkinase_Tyr Protein tyrosine kinase comp116371_c0 244.744705598 0.0 0.0 1.0 MED_UP protein phosphatase 1a F:signal transducer activity; F:manganese ion binding; P:negative regulation of transforming growth factor beta receptor signaling pathway; F:calmodulin-dependent protein phosphatase activity; P:peptidyl-threonine dephosphorylation; P:negative regulation of SMAD protein complex assembly; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; F:magnesium ion binding; P:positive regulation of transcription, DNA-dependent; C:nucleus; P:positive regulation of Wnt receptor signaling pathway; F:R-SMAD binding PP2C Protein phosphatase 2C comp118724_c1 17.7658124132 24.4047372631 98.0086477872 0.999999999835 NRP_UP protein wnt-5a F:receptor binding; P:multicellular organismal development; P:Wnt receptor signaling pathway; C:proteinaceous extracellular matrix; C:extracellular region wnt wnt family comp118724_c4 17.2027281334 28.4400429625 103.501313871 0.999999999965 NRP_UP wingless protein F:receptor binding; P:multicellular organismal development; P:Wnt receptor signaling pathway; C:proteinaceous extracellular matrix; C:extracellular region wnt wnt family comp119263_c1 20.7550909495 33.2533618337 138.710813549 1.0 NRP_UP unclassified wnt ligand 9 F:receptor binding; P:multicellular organismal development; P:Wnt receptor signaling pathway; C:proteinaceous extracellular matrix; C:extracellular region wnt wnt family comp125707_c0 988.591896911 0.197140872139 0.0 1.0 MED_UP histone deacetylase 2, histone deacetylase 2-like P:facial nucleus development; P:positive regulation of neurogenesis; P:neuron migration; F:NAD-dependent histone deacetylase activity (H3-K9 specific); P:oligodendrocyte differentiation; P:histone H3 deacetylation; P:Wnt receptor signaling pathway; F:NAD-dependent histone deacetylase activity (H3-K14 specific); P:regulation of transcription, DNA-dependent; P:hematopoietic stem cell differentiation; P:convergent extension involved in axis elongation; P:histone H4 deacetylation; P:negative regulation of cell proliferation; P:melanocyte differentiation; F:NAD-dependent histone deacetylase activity (H3-K18 specific); P:digestive tract development; P:rostrocaudal neural tube patterning; P:determination of dorsal identity; F:NAD-dependent histone deacetylase activity (H4-K16 specific); P:exocrine pancreas development; P:liver development; C:nucleus, P:facial nucleus development; P:positive regulation of neurogenesis; P:neuron migration; F:NAD-dependent histone deacetylase activity (H3-K9 specific); P:oligodendrocyte differentiation; P:histone H3 deacetylation; P:Wnt receptor signaling pathway; F:NAD-dependent histone deacetylase activity (H3-K14 specific); P:regulation of transcription, DNA-dependent; P:hematopoietic stem cell differentiation; P:convergent extension involved in axis elongation; P:histone H4 deacetylation; C:cytoplasm; P:negative regulation of cell proliferation; P:melanocyte differentiation; F:NAD-dependent histone deacetylase activity (H3-K18 specific); P:digestive tract development; P:rostrocaudal neural tube patterning; P:determination of dorsal identity; F:NAD-dependent histone deacetylase activity (H4-K16 specific); P:exocrine pancreas development; P:liver development; C:nucleus Hist_deacetyl Histone deacetylase domain comp39769_c0 23.7439363476 0.0 0.0 1.0 MED_UP transducin-like enhancer protein 1 C:cytosol; F:RNA polymerase II transcription corepressor activity; P:Wnt receptor signaling pathway; C:transcription factor complex; P:negative regulation of transcription from RNA polymerase II promoter; P:negative regulation of anoikis; P:positive regulation of gene expression; F:transcription factor binding; F:chromatin binding; C:nucleus; P:negative regulation of I-kappaB kinase/NF-kappaB cascade TLE_N Groucho/TLE N-terminal Q-rich domain comp117851_c0 657.595882768 791.966683016 588.070233186 0.999999828687 RP_UP casein kinase i isoform alpha isoform x3 C:cytosol; P:protein phosphorylation; P:Wnt receptor signaling pathway; F:protein serine/threonine kinase activity; P:cell morphogenesis; C:nuclear speck; C:centrosome; P:cell division; F:ATP binding; F:protein binding; P:mitosis; C:ribonucleoprotein complex; C:condensed chromosome kinetochore; C:mRNA cleavage and polyadenylation specificity factor complex Pfam-B_584 comp126413_c1 242.937076775 374.910631535 100.387774857 1.0 RP_UP proto-oncogene wnt-3-like P:multicellular organismal development; C:proteinaceous extracellular matrix; F:receptor binding; P:Wnt receptor signaling pathway wnt wnt family comp126413_c0 310.023673248 394.503988754 95.5428290661 1.0 NRP_DOWN proto-oncogene wnt-3-like P:multicellular organismal development; C:proteinaceous extracellular matrix; F:receptor binding; P:Wnt receptor signaling pathway wnt wnt family comp120479_c0 75.3489397088 0.0 0.423302304351 1.0 MED_UP transcription factor 7-like 1-a-like isoform x2 P:Wnt receptor signaling pathway HMG_box HMG (high mobility group) box comp127364_c0 637.323668109 0.0 0.0 1.0 MED_UP phosphatase and tensin-like protein b long splice variant, phosphatidylinositol -trisphosphate 3-phosphatase and dual-specificity protein phosphatase pten P:hemopoiesis; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; P:convergent extension involved in gastrulation; F:protein tyrosine/serine/threonine phosphatase activity; P:negative regulation of cell migration; P:inositol phosphate dephosphorylation; F:PDZ domain binding; F:protein tyrosine phosphatase activity; P:regulation of protein stability; F:lipid phosphatase activity; P:blood vessel development; P:negative regulation of focal adhesion assembly; P:phosphatidylinositol dephosphorylation; P:lifelong otolith mineralization; P:negative regulation of cell proliferation; P:peptidyl-tyrosine dephosphorylation; F:magnesium ion binding; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; P:negative regulation of protein kinase B signaling cascade, P:positive regulation of excitatory postsynaptic membrane potential; F:PDZ domain binding; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; C:myelin sheath adaxonal region; F:protein kinase binding; P:negative regulation of myelination; P:canonical Wnt receptor signaling pathway; P:central nervous system neuron axonogenesis; P:locomotor rhythm; P:central nervous system myelin maintenance; P:cardiac muscle tissue development; P:endothelial cell migration; F:protein tyrosine/serine/threonine phosphatase activity; C:cytoplasm; P:rhythmic synaptic transmission; F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; P:postsynaptic density assembly; P:angiogenesis; C:Schmidt-Lanterman incisure; P:forebrain morphogenesis; P:negative regulation of apoptotic process; P:negative regulation of cell migration; P:positive regulation of cell proliferation; F:phosphatidylinositol-3-phosphatase activity; P:induction of apoptosis; P:long-term synaptic potentiation; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; F:protein serine/threonine phosphatase activity; P:protein stabilization; P:inositol phosphate dephosphorylation; P:learning or memory; P:social behavior; C:neuron projection; C:nucleus; P:dentate gyrus development; P:negative regulation of cell aging; P:activation of mitotic anaphase-promoting complex activity; F:magnesium ion binding; P:negative regulation of synaptic vesicle clustering; P:negative regulation of organ growth; P:peptidyl-tyrosine dephosphorylation; P:negative regulation of epithelial cell proliferation; P:phosphatidylinositol dephosphorylation; P:multicellular organismal response to stress; P:regulation of B cell apoptotic process; P:negative regulation of axonogenesis; P:negative regulation of protein kinase B signaling cascade; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; P:positive regulation of sequence-specific DNA binding transcription factor activity; P:negative regulation of dendritic spine morphogenesis; P:neuron-neuron synaptic transmission; P:maternal behavior; F:anaphase-promoting complex binding; P:presynaptic membrane assembly; P:negative regulation of cell size; P:negative regulation of ribosome biogenesis; P:negative regulation of focal adhesion assembly; F:protein tyrosine phosphatase activity; P:prepulse inhibition; P:regulation of myeloid cell apoptotic process; P:prostate gland growth; C:internal side of plasma membrane; P:negative regulation of excitatory postsynaptic membrane potential; P:male mating behavior; P:synapse maturation PTEN_C2 C2 domain of PTEN tumour-suppressor protein comp108470_c0 207.523239272 0.0 0.0 1.0 MED_UP transcription factor 7-like 1-like isoform x6 P:Wnt receptor signaling pathway HMG_box HMG (high mobility group) box comp121044_c0 518.984651365 792.737747494 448.611286581 0.99999995782 RP_UP csk21_xenla ame: full=casein kinase ii subunit alpha short=ck ii P:Wnt receptor signaling pathway; P:protein phosphorylation; F:ATP binding; F:protein serine/threonine kinase activity Pkinase Protein kinase domain comp116502_c0 592.471116552 0.345691657283 2.18152769758 1.0 MED_UP ras-related c3 botulinum toxin substrate 1 (rho small gtp binding protein rac1) P:positive regulation of apoptotic process; P:neurotrophin TRK receptor signaling pathway; C:extrinsic to plasma membrane; F:GTP binding; P:inflammatory response; P:regulation of cell migration; P:positive regulation of actin filament polymerization; P:dendrite morphogenesis; P:negative regulation of receptor-mediated endocytosis; P:apoptotic signaling pathway; C:trans-Golgi network; P:cell-matrix adhesion; P:axon guidance; P:engulfment of apoptotic cell; P:ruffle assembly; P:anatomical structure arrangement; P:auditory receptor cell morphogenesis; C:lamellipodium; P:T cell costimulation; C:cytosol; P:Fc-gamma receptor signaling pathway involved in phagocytosis; P:platelet activation; P:positive regulation of phosphatidylinositol 3-kinase activity; P:regulation of defense response to virus by virus; P:cochlea morphogenesis; C:phagocytic cup; P:cell migration involved in gastrulation; C:Golgi membrane; P:positive regulation of DNA replication; P:epithelial cell morphogenesis; P:positive regulation of Rho protein signal transduction; P:myoblast fusion; P:Rac protein signal transduction; P:cell-cell junction organization; P:substrate adhesion-dependent cell spreading; P:innate immune response; P:regulation of hydrogen peroxide metabolic process; P:mast cell chemotaxis; F:Rab GTPase binding; P:localization within membrane; P:viral process; P:Fc-epsilon receptor signaling pathway; C:melanosome; F:thioesterase binding; F:GTP-dependent protein binding; F:protein kinase binding; P:cell proliferation; P:bone resorption; P:hyperosmotic response; F:GTPase activity; P:regulation of respiratory burst; P:positive regulation of lamellipodium assembly; P:dopaminergic neuron differentiation; P:Wnt receptor signaling pathway, planar cell polarity pathway; P:GTP catabolic process; P:embryonic olfactory bulb interneuron precursor migration; C:ruffle membrane; P:cerebral cortex radially oriented cell migration; P:negative regulation of interleukin-23 production Ras Ras family comp125325_c0 896.058703056 0.0 0.70329015729 1.0 MED_UP serine threonine-protein phosphatase 2a catalytic subunit alpha isoform P:regulation of protein autophosphorylation; P:mesoderm development; F:protein C-terminus binding; P:regulation of Wnt receptor signaling pathway; P:protein heterotrimerization; P:response to hydrogen peroxide; P:protein dephosphorylation; P:second-messenger-mediated signaling; P:meiosis; C:protein phosphatase type 2A complex; F:metal ion binding; C:cytosol; P:negative regulation of tyrosine phosphorylation of Stat3 protein; P:RNA splicing; P:regulation of receptor activity; P:ceramide metabolic process; P:inactivation of MAPK activity; P:response to antibiotic; P:regulation of protein catabolic process; C:plasma membrane; P:regulation of cell adhesion; P:negative regulation of epithelial to mesenchymal transition; C:spindle pole; P:positive regulation of protein serine/threonine kinase activity; C:mitochondrion; P:proteasomal ubiquitin-dependent protein catabolic process; P:regulation of DNA replication; F:protein serine/threonine phosphatase activity; F:protein heterodimerization activity; C:chromosome, centromeric region; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; P:negative regulation of apoptotic process; P:fibroblast growth factor receptor signaling pathway; C:nucleus; P:negative regulation of cell growth; P:mitotic nuclear envelope reassembly; P:regulation of transcription, DNA-dependent; P:induction of apoptosis Metallophos Calcineurin-like phosphoesterase comp64661_c0 17.8299022622 0.0 0.0 0.999999999973 MED_UP frizzled homolog 7a F:G-protein coupled receptor activity; P:convergent extension involved in gastrulation; P:epiboly; P:Wnt receptor signaling pathway; C:plasma membrane; P:cell migration involved in gastrulation; F:Wnt-activated receptor activity; P:G-protein coupled receptor signaling pathway; C:integral to membrane Frizzled Frizzled/Smoothened family membrane region comp120465_c0 146.241255498 281.624925144 92.3835856518 1.0 RP_UP daple_xenla ame: full=daple-like protein ame: full=coiled-coil domain-containing protein 88c-like ame: full=dvl-associating protein with a high frequency of leucine residues-like short=xdal F:PDZ domain binding; P:dorsal/ventral axis specification; P:establishment of planar polarity; P:Wnt receptor signaling pathway; P:Wnt receptor signaling pathway, planar cell polarity pathway; P:canonical Wnt receptor signaling pathway; P:activation of JUN kinase activity ---NA--- comp90777_c0 123.720798447 0.197140872139 0.403920489791 1.0 MED_UP serine threonine-protein kinase stk11 P:system development; F:protein binding; P:homeostatic process; F:nucleotide binding; C:intracellular membrane-bounded organelle; P:Wnt receptor signaling pathway; P:developmental process involved in reproduction; P:regulation of cell growth; F:protein kinase activity; P:apoptotic process; F:ion binding; P:cell development; P:negative regulation of cell proliferation; P:regulation of multicellular organismal development; P:protein phosphorylation; P:positive regulation of cellular process; P:regulation of signal transduction; C:cytoplasmic part; P:cellular process involved in reproduction; P:intracellular signal transduction ---NA--- comp126093_c1 820.718468529 0.0 0.827222794142 1.0 MED_UP protein wnt-11b-like ["P:negative regulation of transcription, DNA-dependent; F:frizzled binding; F:protein homodimerization activity; P:pancreas development; P:establishment of mitotic spindle orientation; P:positive regulation of protein kinase C signaling cascade; P:dorsal/ventral axis specification; P:dorsal fin development; P:negative regulation of cell migration; C:protein complex; P:cell-cell adhesion; P:mediolateral intercalation; C:extracellular space; P:heart looping; P:Kupffer's vesicle development; F:transcription regulatory region DNA binding; P:positive regulation of Ras GTPase activity; F:Ras GTPase activator activity; P:gastrulation with mouth forming second; C:plasma membrane; C:cytoplasm; F:Wnt-protein binding; P:positive regulation of stress fiber assembly; P:neuron differentiation; C:proteinaceous extracellular matrix; P:heart induction; P:protein localization to cell surface; P:positive regulation of cell migration; P:eye field cell fate commitment involved in camera-type eye formation; P:central nervous system development; F:growth factor binding; P:positive regulation of transcription, DNA-dependent; P:positive regulation of JNK cascade; P:regulation of endocytosis; P:regulation of gastrulation; P:negative regulation of canonical Wnt receptor signaling pathway; P:neuroendocrine cell differentiation; P:mesodermal cell migration; P:Wnt receptor signaling pathway, planar cell polarity pathway; P:palate development; P:negative regulation of apoptotic process; P:pronephros development; P:negative regulation of cell growth; P:neural crest cell fate specification; P:neural crest cell migration; P:neural plate morphogenesis; P:positive regulation of protein kinase activity; F:protein kinase activator activity"] wnt wnt family comp126093_c0 759.374144322 0.0 0.0 1.0 MED_UP protein wnt-11b-like ["P:negative regulation of transcription, DNA-dependent; F:frizzled binding; F:protein homodimerization activity; P:pancreas development; P:establishment of mitotic spindle orientation; P:positive regulation of protein kinase C signaling cascade; P:dorsal/ventral axis specification; P:dorsal fin development; P:negative regulation of cell migration; C:protein complex; P:cell-cell adhesion; P:mediolateral intercalation; C:extracellular space; P:heart looping; P:Kupffer's vesicle development; F:transcription regulatory region DNA binding; P:positive regulation of Ras GTPase activity; F:Ras GTPase activator activity; P:gastrulation with mouth forming second; C:plasma membrane; C:cytoplasm; F:Wnt-protein binding; P:positive regulation of stress fiber assembly; P:neuron differentiation; C:proteinaceous extracellular matrix; P:heart induction; P:protein localization to cell surface; P:positive regulation of cell migration; P:eye field cell fate commitment involved in camera-type eye formation; P:central nervous system development; F:growth factor binding; P:positive regulation of transcription, DNA-dependent; P:positive regulation of JNK cascade; P:regulation of endocytosis; P:regulation of gastrulation; P:negative regulation of canonical Wnt receptor signaling pathway; P:neuroendocrine cell differentiation; P:mesodermal cell migration; P:Wnt receptor signaling pathway, planar cell polarity pathway; P:palate development; P:negative regulation of apoptotic process; P:pronephros development; P:negative regulation of cell growth; P:neural crest cell fate specification; P:neural crest cell migration; P:neural plate morphogenesis; P:positive regulation of protein kinase activity; F:protein kinase activator activity"] wnt wnt family comp39168_c0 44.1551482412 0.0 0.0 1.0 MED_UP zinc finger protein snai2 C:nuclear chromatin; P:cell migration involved in endocardial cushion formation; P:epithelial to mesenchymal transition involved in endocardial cushion formation; P:negative regulation of stem cell proliferation; P:cellular response to ionizing radiation; P:white fat cell differentiation; P:cellular response to epidermal growth factor stimulus; F:metal ion binding; P:sensory perception of sound; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; P:negative regulation of catenin import into nucleus; P:negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter; P:negative regulation of vitamin D biosynthetic process; P:negative regulation of chondrocyte differentiation; P:negative regulation of anoikis; P:epithelium development; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; P:Notch signaling pathway; P:desmosome disassembly; C:cytoplasm; P:negative regulation of keratinocyte proliferation; P:positive regulation of histone acetylation; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; P:regulation of osteoblast differentiation; F:chromatin binding; P:positive regulation of cell migration; P:regulation of chemokine production; P:pigmentation; P:negative regulation of vitamin D receptor signaling pathway; P:regulation of tight junction assembly; F:sequence-specific DNA binding; P:negative regulation of canonical Wnt receptor signaling pathway; P:negative regulation of cell adhesion involved in substrate-bound cell migration; P:palate development; P:positive regulation of fat cell differentiation; P:neural crest cell development; P:cartilage morphogenesis ---NA--- comp108937_c0 1526.27420327 0.345691657283 0.70329015729 1.0 MED_UP secreted frizzled-related protein 2-like, secreted frizzled-related protein 2 C:cytoplasm; P:embryo development; C:plasma membrane; F:Wnt-protein binding; P:vasculature development; F:Wnt-activated receptor activity; P:brain development; P:gonad development; P:canonical Wnt receptor signaling pathway; F:PDZ domain binding; C:cell projection, P:Wnt receptor signaling pathway; F:protein binding; C:cell part; P:organ development; P:single-organism developmental process Fz Fz domain comp98510_c0 33.2446726813 0.0 0.0 1.0 MED_UP cadherin-2- partial P:cell migration; P:blood vessel morphogenesis; F:beta-catenin binding; P:positive regulation of muscle cell differentiation; P:positive regulation of MAPK cascade; F:calcium ion binding; C:integral to membrane; P:homophilic cell adhesion; P:calcium-dependent cell-cell adhesion; P:heterophilic cell-cell adhesion; F:phospholipid binding; C:synapse; P:adherens junction organization; C:catenin complex; P:striated muscle cell differentiation; F:protein phosphatase binding; P:negative regulation of canonical Wnt receptor signaling pathway; F:gamma-catenin binding; P:cell junction assembly; C:apical plasma membrane; F:alpha-catenin binding; C:lamellipodium; C:fascia adherens ---NA--- comp112807_c0 145.614644906 30.4535825648 11.9353906878 1.0 MED_UP gata2 transcription factor, gata-binding protein 1 C:nucleus; P:definitive hemopoiesis; P:primitive hemopoiesis; P:erythrocyte differentiation; P:regulation of transcription, DNA-dependent; P:embryonic hemopoiesis; P:embryo development; F:sequence-specific DNA binding transcription factor activity; P:regulation of myeloid cell differentiation; P:negative regulation of gene expression; P:positive regulation of transcription from RNA polymerase II promoter; P:macrophage differentiation; P:monocyte differentiation; F:sequence-specific DNA binding; F:zinc ion binding; P:myeloid cell differentiation; P:erythrocyte development; P:negative regulation of apoptotic process; F:double-stranded DNA binding, P:regulation of neuron apoptotic process; P:male gonad development; F:enhancer sequence-specific DNA binding; P:response to virus; P:erythrocyte differentiation; P:lens development in camera-type eye; P:negative regulation of fat cell differentiation; P:canonical Wnt receptor signaling pathway involved in metanephric kidney development; F:HMG box domain binding; P:negative regulation of cell motility; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; P:parathyroid hormone secretion; P:negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation; F:RNA polymerase II core promoter sequence-specific DNA binding; P:negative regulation of interleukin-2 production; P:in utero embryonic development; P:mast cell differentiation; F:transcription factor binding; P:T cell receptor signaling pathway; P:TOR signaling cascade; P:negative regulation of mammary gland epithelial cell proliferation; P:positive regulation of interleukin-13 secretion; P:inner ear morphogenesis; F:zinc ion binding; P:T-helper 2 cell differentiation; P:uterus development; P:ureter maturation; P:positive regulation of T cell differentiation; P:regulation of cellular response to X-ray; P:interferon-gamma secretion; P:positive regulation of interleukin-5 secretion; P:negative regulation of endothelial cell apoptotic process; P:cellular response to interferon-alpha; P:otic vesicle development; P:positive regulation of thyroid hormone generation; P:sympathetic nervous system development; P:pharyngeal system development; P:cell fate determination; P:negative regulation of inflammatory response; P:cellular response to tumor necrosis factor; P:developmental growth; P:positive regulation of transcription from RNA polymerase II promoter; P:neuron migration; P:positive regulation of transcription regulatory region DNA binding; P:ventricular septum development; P:interleukin-4 secretion; P:thymus development; P:pro-T cell differentiation; P:embryonic hemopoiesis; P:humoral immune response; P:norepinephrine biosynthetic process; P:thymic T cell selection; P:positive regulation of endothelial cell migration; F:E-box binding; P:parathyroid gland development; P:cellular response to BMP stimulus; P:regulation of establishment of cell polarity; P:cardiac right ventricle morphogenesis; F:interleukin-2 receptor binding; P:regulation of histone H3-K4 methylation; C:nucleolus; P:regulation of nephron tubule epithelial cell differentiation; P:negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation; P:axon guidance; F:protein dimerization activity; P:post-embryonic development; P:regulation of cytokine biosynthetic process; P:nephric duct formation; P:response to estrogen stimulus; P:negative regulation of cell cycle; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; P:negative regulation of cell proliferation involved in mesonephros development; P:negative regulation of transcription from RNA polymerase II promoter; P:positive regulation of ureteric bud formation; C:nuclear chromatin; F:transcription coactivator activity; P:positive regulation of interleukin-13 production; P:negative regulation of interferon-gamma production; F:core promoter proximal region sequence-specific DNA binding; P:cell maturation; P:regulation of histone H3-K27 methylation; P:lymphocyte migration; P:positive regulation of interleukin-4 production; P:positive regulation of interleukin-5 production; P:regulation of CD4-positive, alpha-beta T cell differentiation; P:aortic valve morphogenesis; P:positive regulation of protein kinase B signaling cascade; P:phosphatidylinositol 3-kinase cascade; P:cellular response to interleukin-4; P:mesenchymal to epithelial transition ---NA--- comp127639_c0 1278.58323498 0.0 0.423302304351 1.0 MED_UP ubiquitin thioesterase zranb1 P:cell migration; F:ubiquitin thiolesterase activity; F:zinc ion binding; P:regulation of cell morphogenesis; F:K63-linked polyubiquitin binding; P:positive regulation of Wnt receptor signaling pathway; P:cytoskeleton organization; P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process; P:protein K63-linked deubiquitination; F:ubiquitin-specific protease activity; C:cytoplasm; C:nucleus OTU OTU-like cysteine protease comp101538_c0 42.9578667358 0.0 0.0 1.0 MED_UP e3 ubiquitin-protein ligase ubr5 P:progesterone receptor signaling pathway; P:positive regulation of protein import into nucleus, translocation; P:positive regulation of canonical Wnt receptor signaling pathway; F:zinc ion binding; F:ubiquitin-ubiquitin ligase activity; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; F:ubiquitin binding; C:cytoplasm; P:negative regulation of histone H2A K63-linked ubiquitination; P:positive regulation of catenin import into nucleus; F:RNA binding; C:nucleus; P:negative regulation of double-strand break repair Pfam-B_664 comp121964_c1 822.494979241 0.155260072542 182.686651258 1.0 RP_DOWN dna damage-binding protein 1 P:proteasomal ubiquitin-dependent protein catabolic process; P:cell cycle checkpoint; P:Wnt receptor signaling pathway; F:damaged DNA binding; P:DNA repair; C:Cul4A-RING ubiquitin ligase complex; C:Cul4B-RING ubiquitin ligase complex; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; C:cytoplasm; C:nucleus MMS1_N Mono-functional DNA-alkylating methyl methanesulfonate N-term comp98940_c0 61.3921120514 0.0 0.0 1.0 MED_UP transcription factor 7-like 1, transcription factor 7-like 1-a-like isoform x2 P:Wnt receptor signaling pathway CTNNB1_binding N-terminal CTNNB1 binding comp127833_c0 155.36466471 286.730715433 162.335955525 0.999999990969 RP_UP leucine-rich repeat flightless-interacting protein 2 isoform 3, leucine-rich repeat flightless-interacting protein 2-like P:dorsal/ventral axis specification; P:Wnt receptor signaling pathway DUF2051 Double stranded RNA binding protein (DUF2051) comp127833_c1 132.003924813 294.70976174 158.991967269 1.0 RP_UP leucine-rich repeat flightless-interacting protein 2 isoform 3, leucine-rich repeat flightless-interacting protein 2-like P:dorsal/ventral axis specification; P:Wnt receptor signaling pathway DUF2051 Double stranded RNA binding protein (DUF2051) comp117558_c2 3.30404136772 11.1971341847 31.6792493547 0.99999999701 NRP_UP low-density lipoprotein receptor-related protein 4- partial P:embryonic digit morphogenesis; F:serine-type endopeptidase activity; P:kidney development; P:synaptic growth at neuromuscular junction; F:receptor tyrosine kinase binding; P:hair follicle development; C:cell surface; P:regulation of systemic arterial blood pressure by atrial natriuretic peptide; P:negative regulation of Wnt receptor signaling pathway; P:female pregnancy; P:regulation of protein phosphorylation; P:odontogenesis of dentin-containing tooth; P:peptide hormone processing; P:regulation of renal sodium excretion; P:dorsal/ventral pattern formation; P:proximal/distal pattern formation; F:protein homodimerization activity; C:plasma membrane; P:receptor clustering Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain comp116280_c0 227.317989193 0.0 0.0 1.0 MED_UP bmp and activin membrane-bound inhibitor homolog P:positive regulation of protein binding; P:positive regulation of canonical Wnt receptor signaling pathway; P:regulation of cell shape; C:membrane; F:frizzled binding; C:cytoplasm; P:positive regulation of cell proliferation; P:positive regulation of catenin import into nucleus; P:positive regulation of transcription, DNA-dependent; P:positive regulation of epithelial to mesenchymal transition; P:cell migration BAMBI BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain comp114560_c0 44.9869445198 0.0 0.0 1.0 MED_UP e3 ubiquitin-protein ligase rnf146, e3 ubiquitin-protein ligase rnf146 isoform x2 C:cytosol; F:poly-ADP-D-ribose binding; F:zinc ion binding; P:protein K48-linked ubiquitination; F:ubiquitin-protein ligase activity; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; P:positive regulation of canonical Wnt receptor signaling pathway; P:protein autoubiquitination, P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; P:protein autoubiquitination; F:zinc ion binding; P:protein K48-linked ubiquitination; F:ubiquitin-protein ligase activity; F:metal ion binding; C:cytosol; P:positive regulation of canonical Wnt receptor signaling pathway; F:poly-ADP-D-ribose binding; F:ligase activity; C:nucleus; C:cytoplasm; P:protein ubiquitination; P:Wnt receptor signaling pathway WWE WWE domain comp126156_c0 645.165948536 0.0 0.70329015729 1.0 MED_UP lim domain-binding protein 1 isoform x2 C:cell-cell junction; P:Wnt receptor signaling pathway; P:negative regulation of erythrocyte differentiation; P:cerebellar Purkinje cell differentiation; F:transcription cofactor activity; P:histone H3-K4 acetylation; F:protein self-association; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; P:positive regulation of hemoglobin biosynthetic process; P:gastrulation with mouth forming second; P:hair follicle development; P:negative regulation of transcription, DNA-dependent; P:regulation of DNA-dependent transcription, elongation; P:head development; P:somatic stem cell maintenance; F:LIM domain binding; P:cellular component assembly; C:transcription factor complex; P:epithelial structure maintenance; P:positive regulation of cell adhesion; F:RNA polymerase II activating transcription factor binding; P:anterior/posterior axis specification; C:nuclear chromatin; P:positive regulation of transcription from RNA polymerase II promoter; F:enhancer sequence-specific DNA binding; F:protein homodimerization activity; F:chromatin binding; F:enzyme binding, C:cell-cell junction; P:Wnt receptor signaling pathway; P:negative regulation of erythrocyte differentiation; P:cerebellar Purkinje cell differentiation; F:transcription cofactor activity; P:histone H3-K4 acetylation; F:protein self-association; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; P:positive regulation of hemoglobin biosynthetic process; P:gastrulation with mouth forming second; P:hair follicle development; P:negative regulation of transcription, DNA-dependent; P:head development; P:regulation of DNA-dependent transcription, elongation; P:somatic stem cell maintenance; F:LIM domain binding; P:cellular component assembly; C:transcription factor complex; P:epithelial structure maintenance; P:positive regulation of cell adhesion; F:RNA polymerase II activating transcription factor binding; P:anterior/posterior axis specification; C:nuclear chromatin; P:positive regulation of transcription from RNA polymerase II promoter; F:enhancer sequence-specific DNA binding; F:protein homodimerization activity; F:chromatin binding; F:enzyme binding LIM_bind LIM-domain binding protein comp119487_c0 70.2464768328 0.0 0.0 1.0 MED_UP e3 ubiquitin protein hect domain isoform cra_c P:progesterone receptor signaling pathway; P:positive regulation of protein import into nucleus, translocation; P:positive regulation of canonical Wnt receptor signaling pathway; F:zinc ion binding; F:ubiquitin-ubiquitin ligase activity; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; P:cell proliferation; F:ubiquitin binding; C:cytoplasm; P:negative regulation of histone H2A K63-linked ubiquitination; P:positive regulation of catenin import into nucleus; F:RNA binding; C:nucleus; P:negative regulation of double-strand break repair ---NA--- comp119263_c0 14.8336158996 27.1976751823 119.179734141 0.999999999945 NRP_UP unclassified wnt ligand 9 F:receptor binding; P:multicellular organismal development; P:Wnt receptor signaling pathway; C:proteinaceous extracellular matrix; C:extracellular region wnt wnt family comp94785_c0 83.5002369737 0.0 0.0 1.0 MED_UP frizzled homolog 7a C:integral to membrane; P:brain development; F:G-protein coupled receptor activity; F:Wnt-protein binding; P:epiboly; P:canonical Wnt receptor signaling pathway; F:PDZ domain binding; C:neuron projection membrane; F:Wnt-activated receptor activity; P:vasculature development; P:axonogenesis; P:epithelial cell differentiation; P:Wnt receptor signaling pathway, calcium modulating pathway; P:cell migration involved in gastrulation; P:gonad development; C:cytoplasm; P:G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; C:apical part of cell; P:convergent extension involved in gastrulation Frizzled Frizzled/Smoothened family membrane region comp90880_c0 30.194907069 0.0 0.0 1.0 MED_UP hmg domain-containing protein 4 P:endosome to lysosome transport; F:DNA binding; C:NURF complex; P:negative regulation of Wnt receptor signaling pathway ---NA--- comp126716_c1 60.1002618763 103.288637578 56.688687157 0.999999982578 RP_UP e3 ubiquitin-protein ligase znrf3 precursor P:non-canonical Wnt receptor signaling pathway; P:negative regulation of Wnt receptor signaling pathway; P:canonical Wnt receptor signaling pathway; C:membrane zf-RING_2 Ring finger domain comp65799_c1 26.6021955452 0.0 0.0 1.0 MED_UP serine threonine-protein kinase lats1 P:sister chromatid segregation; P:positive regulation of peptidyl-serine phosphorylation; P:negative regulation of canonical Wnt receptor signaling pathway; F:protein kinase binding; P:hormone-mediated signaling pathway; P:cytoplasmic sequestering of protein; P:regulation of actin filament polymerization; F:protein serine/threonine kinase activity; F:magnesium ion binding; P:hippo signaling cascade; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; P:keratinocyte differentiation; F:ATP binding; P:G2/M transition of mitotic cell cycle; C:spindle pole Pkinase Protein kinase domain comp126358_c0 728.526325194 0.0 0.0 1.0 MED_UP integral membrane protein gpr177 precursor, protein wntless homolog isoform x2 F:Wnt-protein binding; P:Wnt receptor signaling pathway MIG-14_Wnt-bd Wnt-binding factor required for Wnt secretion comp377441_c0 18.3424307113 0.0 0.0 1.0 MED_UP protein daple P:protein homooligomerization; P:regulation of protein phosphorylation; F:PDZ domain binding; P:protein destabilization; P:Wnt receptor signaling pathway; F:protein self-association; F:protein binding ---NA--- comp102326_c0 56.2761152766 0.0 0.0 1.0 MED_UP f-box-like wd repeat-containing protein tbl1xr1- partial P:canonical Wnt receptor signaling pathway; P:negative regulation of transcription from RNA polymerase II promoter; P:Notch signaling pathway; F:histone binding; F:transcription corepressor activity; P:proteasomal ubiquitin-dependent protein catabolic process; P:cellular lipid metabolic process; C:transcriptional repressor complex; F:protein N-terminus binding; C:nucleolus; F:transcription regulatory region DNA binding; C:histone deacetylase complex; P:small molecule metabolic process; P:positive regulation of transcription from RNA polymerase II promoter; C:spindle microtubule; F:beta-catenin binding; P:chromatin modification WD40 WD domain comp121829_c1 95.711930241 203.823666611 91.6310276527 0.999999733884 RP_UP frizzled receptor C:integral to membrane; P:G-protein coupled receptor signaling pathway; P:multicellular organismal development; P:Wnt receptor signaling pathway; F:G-protein coupled receptor activity Frizzled Frizzled/Smoothened family membrane region comp229323_c0 45.9428665469 0.0 0.0 1.0 MED_UP lim domain-containing protein 1 isoform x2 C:focal adhesion; P:cytoskeleton organization; P:positive regulation of gene silencing by miRNA; F:transcription corepressor activity; P:regulation of cell shape; F:zinc ion binding; P:negative regulation of canonical Wnt receptor signaling pathway; C:RNA-induced silencing complex; P:phosphorylation; P:negative regulation of transcription, DNA-dependent; P:response to hypoxia; P:negative regulation of osteoblast differentiation; P:negative regulation of hippo signaling cascade; C:cytoplasmic mRNA processing body; P:osteoblast development; C:nucleus; P:cell migration; P:cytoplasmic mRNA processing body assembly ---NA--- comp111608_c0 166.469992383 0.0 0.0 1.0 MED_UP transmembrane protein 237 P:cilium assembly; P:regulation of Wnt receptor signaling pathway; C:ciliary transition zone ---NA--- comp124859_c0 3.87861979022 31.8527230548 34.5248518794 1.0 MED_DOWN fgfr3 4a P:epidermal growth factor receptor signaling pathway; P:Fc-epsilon receptor signaling pathway; P:regulation of growth; P:organ growth; P:regulation of ERK1 and ERK2 cascade; P:multicellular organism growth; P:protein autophosphorylation; P:regulation of transcription from RNA polymerase II promoter; P:branching involved in prostate gland morphogenesis; P:epithelial tube morphogenesis; P:mammary gland morphogenesis; P:cardiac muscle tissue development; P:in utero embryonic development; F:fibroblast growth factor binding; F:protein homodimerization activity; P:innate immune response; P:inner ear morphogenesis; P:embryonic cranial skeleton morphogenesis; P:lung morphogenesis; P:muscle cell differentiation; P:pattern specification process; P:branching involved in salivary gland morphogenesis; P:regulation of cell cycle; C:cell cortex; F:fibroblast growth factor-activated receptor activity; P:cardiac septum morphogenesis; P:prostate glandular acinus development; P:mesenchymal cell differentiation; C:cell surface; P:neurotrophin TRK receptor signaling pathway; P:cell-cell signaling; P:regulation of morphogenesis of a branching structure; P:negative regulation of cellular process; P:positive regulation of phospholipase activity; P:mesenchymal cell proliferation; C:nucleus; P:branch elongation of an epithelium; P:digestive tract morphogenesis; P:cardiac ventricle development; P:epidermis morphogenesis; P:anatomical structure formation involved in morphogenesis; P:cell division; P:orbitofrontal cortex development; P:phosphatidylinositol-mediated signaling; P:peptidyl-tyrosine phosphorylation; P:regulation of organ morphogenesis; P:epithelial cell differentiation; P:bone morphogenesis; P:regulation of osteoblast differentiation; P:cell fate commitment; P:positive regulation of Wnt receptor signaling pathway; P:cellular component organization; P:regulation of osteoblast proliferation; P:positive regulation of MAPK cascade; C:extracellular matrix; P:fibroblast growth factor receptor signaling pathway; P:muscle organ development; P:neuron development; P:morphogenesis of embryonic epithelium; P:positive regulation of epithelial cell proliferation; P:insulin receptor signaling pathway; P:forebrain generation of neurons; C:integral to plasma membrane Pkinase_Tyr Protein tyrosine kinase comp123001_c0 572.241936897 0.0 0.0 1.0 MED_UP serine threonine-protein phosphatase 2a catalytic subunit alpha isoform P:regulation of protein autophosphorylation; P:mesoderm development; F:protein C-terminus binding; P:regulation of Wnt receptor signaling pathway; P:protein heterotrimerization; P:response to hydrogen peroxide; P:protein dephosphorylation; P:second-messenger-mediated signaling; P:meiosis; C:protein phosphatase type 2A complex; F:metal ion binding; C:cytosol; P:negative regulation of tyrosine phosphorylation of Stat3 protein; P:RNA splicing; P:regulation of receptor activity; P:ceramide metabolic process; P:inactivation of MAPK activity; P:response to antibiotic; P:regulation of protein catabolic process; C:plasma membrane; P:regulation of cell adhesion; P:negative regulation of epithelial to mesenchymal transition; C:spindle pole; P:positive regulation of protein serine/threonine kinase activity; C:mitochondrion; P:proteasomal ubiquitin-dependent protein catabolic process; P:regulation of DNA replication; F:protein serine/threonine phosphatase activity; F:protein heterodimerization activity; C:chromosome, centromeric region; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; P:negative regulation of apoptotic process; P:fibroblast growth factor receptor signaling pathway; C:nucleus; P:negative regulation of cell growth; P:mitotic nuclear envelope reassembly; P:regulation of transcription, DNA-dependent; P:induction of apoptosis Metallophos Calcineurin-like phosphoesterase comp49608_c0 20.6538912885 0.0 0.0 1.0 MED_UP serine threonine-protein kinase stk11 F:LRR domain binding; F:p53 binding; P:canonical Wnt receptor signaling pathway; P:Golgi localization; C:membrane; P:response to DNA damage stimulus; F:protein kinase activator activity; P:intrinsic apoptotic signaling pathway by p53 class mediator; P:vasculature development; P:anoikis; P:positive regulation of axonogenesis; C:cytosol; P:protein autophosphorylation; P:cell cycle arrest; P:regulation of Wnt receptor signaling pathway; F:protein serine/threonine kinase activity; F:identical protein binding; P:spermatid development; P:negative regulation of cell growth; P:positive regulation of protein kinase activity; F:magnesium ion binding; P:positive regulation of transforming growth factor beta receptor signaling pathway; P:establishment of cell polarity; P:negative regulation of epithelial cell proliferation involved in prostate gland development; P:response to ionizing radiation; P:regulation of protein kinase B signaling cascade; C:nucleus; F:ATP binding; P:glucose homeostasis; C:mitochondrion; P:tissue homeostasis ---NA--- comp121625_c0 279.18979079 0.0 0.0 1.0 MED_UP adenomatous polyposis coli protein P:positive regulation of apoptotic process; C:tight junction; P:positive regulation of epithelial cell differentiation; P:mitotic spindle assembly checkpoint; P:negative regulation of MAPK cascade; P:positive regulation of microtubule polymerization; P:somatic stem cell maintenance; P:anterior/posterior pattern specification; P:negative regulation of epithelial cell proliferation involved in prostate gland development; C:axonal growth cone; C:lamellipodium; P:positive regulation of pseudopodium assembly; P:positive regulation of cell adhesion; C:kinetochore; C:cytoplasmic microtubule; P:hair follicle development; P:T cell differentiation in thymus; P:regulation of osteoclast differentiation; F:beta-catenin binding; P:retina development in camera-type eye; P:kidney development; P:positive regulation of cell division; P:regulation of nitrogen compound metabolic process; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; P:axonogenesis; P:axis specification; P:cytoplasmic microtubule organization; P:response to DNA damage stimulus; P:muscle cell cellular homeostasis; F:microtubule plus-end binding; C:cell-cell adherens junction; P:regulation of osteoblast differentiation; P:cell cycle arrest; P:mitotic cytokinesis; P:positive regulation of cell migration; P:dorsal/ventral pattern formation; F:protein kinase binding; F:protein kinase regulator activity; P:regulation of attachment of spindle microtubules to kinetochore; P:negative regulation of odontogenesis; P:proximal/distal pattern formation; P:negative regulation of canonical Wnt receptor signaling pathway; C:beta-catenin destruction complex; P:negative regulation of apoptotic process; C:microtubule plus end; P:chromosome organization; C:nucleus; C:centrosome; C:ruffle membrane; P:thymus development; P:negative regulation of microtubule depolymerization; F:gamma-catenin binding; P:positive regulation of protein catabolic process; C:lateral plasma membrane APC_basic APC basic domain comp127329_c0 113.633258412 225.380663217 179.50760439 1.0 RP_UP src-like b, tyrosine-protein kinase fyn-like isoform x1 F:non-membrane spanning protein tyrosine kinase activity; P:protein phosphorylation; F:ATP binding, C:cytoskeleton; P:neurotrophin TRK receptor signaling pathway; P:signal complex assembly; P:uterus development; P:response to interleukin-1; P:modulation by virus of host morphology or physiology; C:caveola; C:lysosome; P:axon guidance; P:positive regulation of ERK1 and ERK2 cascade; P:peptidyl-tyrosine phosphorylation; P:T cell costimulation; C:cytosol; F:integrin binding; P:forebrain development; F:SH2 domain binding; F:heme binding; P:Fc-gamma receptor signaling pathway involved in phagocytosis; P:negative regulation of focal adhesion assembly; P:platelet activation; P:negative regulation of intrinsic apoptotic signaling pathway; P:negative regulation of anoikis; P:regulation of bone resorption; F:ion channel binding; P:positive regulation of integrin activation; P:leukocyte migration; P:positive regulation of canonical Wnt receptor signaling pathway; P:innate immune response; P:Ras protein signal transduction; P:negative regulation of protein homooligomerization; F:identical protein binding; P:progesterone receptor signaling pathway; P:regulation of protein binding; P:epidermal growth factor receptor signaling pathway; F:ATP binding; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; P:regulation of vascular permeability; F:SH3/SH2 adaptor activity; P:cell cycle; P:cellular membrane organization; P:protein autophosphorylation; P:cellular response to progesterone stimulus; F:phosphoprotein binding; P:positive regulation of podosome assembly; P:positive regulation of protein kinase B signaling cascade; C:mitochondrial inner membrane; F:non-membrane spanning protein tyrosine kinase activity; P:fibroblast growth factor receptor signaling pathway; C:nucleus; C:late endosome; F:ephrin receptor binding; P:negative regulation of extrinsic apoptotic signaling pathway; P:oogenesis; P:regulation of intracellular estrogen receptor signaling pathway; P:branching involved in mammary gland duct morphogenesis Pkinase_Tyr Protein tyrosine kinase comp86787_c0 46.3622993271 0.0 0.0 1.0 MED_UP b-cell cll lymphoma 9 protein F:beta-catenin binding; P:positive regulation of transcription from RNA polymerase II promoter; P:somatic stem cell maintenance; P:myotube differentiation involved in skeletal muscle regeneration; P:canonical Wnt receptor signaling pathway; C:Golgi apparatus; C:nucleus Pfam-B_15180 comp103863_c0 24.3265702277 0.0 0.0 1.0 MED_UP chromodomain-helicase-dna-binding protein 8-like P:ATP-dependent chromatin remodeling; F:p53 binding; P:canonical Wnt receptor signaling pathway; F:DNA-dependent ATPase activity; P:DNA duplex unwinding; P:positive regulation of transcription from RNA polymerase III promoter; P:negative regulation of apoptotic process; P:negative regulation of transcription, DNA-dependent; F:armadillo repeat domain binding; P:negative regulation of Wnt receptor signaling pathway; F:DNA binding; P:positive regulation of transcription from RNA polymerase II promoter; F:beta-catenin binding; F:ATP binding; F:DNA helicase activity; P:in utero embryonic development; F:methylated histone residue binding; C:MLL1 complex ---NA--- comp86615_c0 116.313360113 208.740857143 10.7038929795 0.99999986876 NRP_DOWN secreted signaling factor wnt8 F:receptor binding; P:multicellular organismal development; P:Wnt receptor signaling pathway; C:proteinaceous extracellular matrix; C:extracellular region wnt wnt family comp128668_c0 1443.70279236 0.18256509998 0.423302304351 1.0 MED_UP prickle-like protein 1 F:zinc ion binding; P:negative regulation of canonical Wnt receptor signaling pathway; C:nuclear membrane; P:positive regulation of protein ubiquitination; P:negative regulation of transcription, DNA-dependent; C:cytosol; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; P:negative regulation of cardiac muscle cell myoblast differentiation; P:neural tube closure; P:protein import into nucleus, F:metal ion binding Pfam-B_10170, PET PET Domain comp120117_c0 746.219836649 816.847938039 485.966778934 1.0 NRP_DOWN csk21_xenla ame: full=casein kinase ii subunit alpha short=ck ii P:Wnt receptor signaling pathway; P:protein phosphorylation; F:ATP binding; F:protein serine/threonine kinase activity Pkinase Protein kinase domain comp126032_c0 1832.22087869 0.18256509998 2.58544818737 1.0 MED_UP cell division control protein 42 homolog isoform x2, cell division control protein 42 homolog isoform 1 F:GTP binding; C:intracellular; P:cell migration involved in gastrulation; P:cell cycle; C:membrane; P:small GTPase mediated signal transduction; P:cell division, P:positive regulation of neuron apoptotic process; P:establishment or maintenance of apical/basal cell polarity; F:GTP-dependent protein binding; C:neuronal cell body; P:canonical Wnt receptor signaling pathway; P:epithelial-mesenchymal cell signaling; P:negative regulation of epidermal growth factor receptor signaling pathway; P:negative regulation of protein complex assembly; C:spindle midzone; P:positive regulation of JNK cascade; C:mitotic spindle; P:multicellular organism growth; F:GTP binding; P:GTP catabolic process; P:positive regulation of pseudopodium assembly; P:regulation of filopodium assembly; C:midbody; P:positive regulation of peptidyl-serine phosphorylation; P:innate immune response; C:apical part of cell; P:regulation of attachment of spindle microtubules to kinetochore; P:positive regulation of substrate adhesion-dependent cell spreading; F:identical protein binding; P:positive regulation of intracellular protein transport; P:Fc-gamma receptor signaling pathway involved in phagocytosis; F:thioesterase binding; C:microtubule organizing center; P:nuclear migration; P:blood coagulation; P:organelle transport along microtubule; P:positive regulation of phosphatidylinositol 3-kinase activity; F:mitogen-activated protein kinase kinase kinase binding; P:actin filament branching; P:positive regulation of muscle cell differentiation; P:adherens junction organization; C:plasma membrane; P:keratinization; P:positive regulation of synapse structural plasticity; P:hair follicle placode formation; P:submandibular salivary gland formation; C:neuron projection; P:regulation of mitosis; P:positive regulation of cytokinesis; P:keratinocyte development; P:positive regulation of gene expression; C:cytosol; P:sprouting angiogenesis; P:regulation of protein heterodimerization activity; P:cardiac conduction system development; P:heart contraction; P:axon guidance; P:regulation of protein catabolic process; F:GTPase activity; P:positive regulation of DNA replication; C:secretory granule; P:epithelial cell-cell adhesion; P:regulation of protein stability; P:positive regulation of metalloenzyme activity; P:positive regulation of hair follicle cell proliferation; P:negative regulation of gene expression; P:cell migration involved in gastrulation; P:actin filament bundle assembly; P:macrophage differentiation; C:filopodium; F:apolipoprotein A-I receptor binding; P:T cell costimulation; P:hair follicle morphogenesis; P:establishment of Golgi localization; C:Golgi membrane; P:neuron fate determination; P:regulation of small GTPase mediated signal transduction; P:Golgi organization; P:regulation of protein kinase activity Ras Ras family comp124688_c1 336.670931464 0.0 0.0 1.0 MED_UP ldlr chaperone mesd-like P:protein folding; P:protein localization to cell surface; P:Wnt receptor signaling pathway; C:plasma membrane; F:low-density lipoprotein particle receptor binding; C:endoplasmic reticulum Mesd Chaperone for wingless signalling and trafficking of LDL receptor comp124688_c0 367.619434599 0.0 0.0 1.0 MED_UP ldlr chaperone mesd-like P:protein folding; P:protein localization to cell surface; P:Wnt receptor signaling pathway; C:plasma membrane; F:low-density lipoprotein particle receptor binding; C:endoplasmic reticulum Mesd Chaperone for wingless signalling and trafficking of LDL receptor comp122556_c1 1094.66381339 0.0 0.0 1.0 MED_UP casein kinase ii subunit beta P:negative regulation of blood vessel endothelial cell migration; F:kinase activity; F:receptor binding; P:positive regulation of pathway-restricted SMAD protein phosphorylation; P:Wnt receptor signaling pathway; P:adiponectin-mediated signaling pathway; P:regulation of protein kinase activity; C:protein kinase CK2 complex; C:cytoplasm; F:metal ion binding; F:protein domain specific binding; P:positive regulation of activin receptor signaling pathway; F:identical protein binding; P:endothelial tube morphogenesis; F:protein kinase regulator activity; C:PcG protein complex; C:plasma membrane; F:transcription factor binding CK_II_beta Casein kinase II regulatory subunit comp84438_c0 954.328736105 0.18256509998 0.774947382996 1.0 MED_UP nucleoredoxin-like isoform x1 C:cytosol; P:oxidation-reduction process; F:protein-disulfide reductase activity; P:cardiovascular system development; P:negative regulation of Wnt receptor signaling pathway; P:cell differentiation; P:negative regulation of protein ubiquitination; C:nucleus Thioredoxin_8 Thioredoxin-like comp101370_c0 147.785465425 0.0 0.0 1.0 MED_UP ell-associated factor 2-like P:convergent extension involved in organogenesis; P:regulation of transcription, DNA-dependent; P:pancreas development; P:heart development; P:regulation of Wnt receptor signaling pathway; P:cell migration involved in gastrulation; P:convergent extension involved in axis elongation; P:muscle cell migration; C:ELL-EAF complex EAF RNA polymerase II transcription elongation factor comp114043_c0 116.213474962 92.3842587351 13.477392553 1.0 NRP_DOWN dickkopf-related protein 1-like P:negative regulation of Wnt receptor signaling pathway; P:multicellular organismal development; C:extracellular region Dickkopf_N Dickkopf N-terminal cysteine-rich region comp103748_c1 29.3889162718 0.0 0.0 1.0 MED_UP lim domain-containing protein 1 C:focal adhesion; P:cytoskeleton organization; P:positive regulation of gene silencing by miRNA; F:transcription corepressor activity; P:regulation of cell shape; F:zinc ion binding; P:negative regulation of canonical Wnt receptor signaling pathway; C:RNA-induced silencing complex; P:phosphorylation; P:negative regulation of transcription, DNA-dependent; P:response to hypoxia; P:negative regulation of osteoblast differentiation; P:negative regulation of hippo signaling cascade; C:cytoplasmic mRNA processing body; P:osteoblast development; C:nucleus; P:cell migration; P:cytoplasmic mRNA processing body assembly LIM LIM domain comp103748_c0 188.742544109 0.0 0.0 1.0 MED_UP lim domain-containing protein 1 C:focal adhesion; P:cytoskeleton organization; P:positive regulation of gene silencing by miRNA; F:transcription corepressor activity; P:regulation of cell shape; F:zinc ion binding; P:negative regulation of canonical Wnt receptor signaling pathway; C:RNA-induced silencing complex; P:phosphorylation; P:negative regulation of transcription, DNA-dependent; P:response to hypoxia; P:negative regulation of osteoblast differentiation; P:negative regulation of hippo signaling cascade; C:cytoplasmic mRNA processing body; P:osteoblast development; C:nucleus; P:cell migration; P:cytoplasmic mRNA processing body assembly LIM LIM domain comp347715_c0 17.0437238271 0.0 0.0 1.0 MED_UP apc membrane recruitment protein 1 P:negative regulation of canonical Wnt receptor signaling pathway; F:beta-catenin binding; C:plasma membrane; P:positive regulation of canonical Wnt receptor signaling pathway; F:phosphatidylinositol-4,5-bisphosphate binding ---NA--- comp35370_c0 44.1137667515 0.0 0.0 1.0 MED_UP af363723_1frizzled 2 P:canonical Wnt receptor signaling pathway; P:cell-cell signaling; P:outflow tract morphogenesis; F:PDZ domain binding; P:regulation of transcription from RNA polymerase II promoter; P:G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; P:axonogenesis; F:G-protein coupled receptor activity; P:elevation of cytosolic calcium ion concentration; P:vasculature development; P:positive regulation of sequence-specific DNA binding transcription factor activity; C:integral to membrane; P:gonad development; P:inner ear receptor cell development; C:neuron projection membrane; C:cytoplasm; F:protein heterodimerization activity; P:hard palate development; P:membranous septum morphogenesis; P:muscular septum morphogenesis; P:brain development; P:cochlea morphogenesis; F:Wnt-activated receptor activity; P:Wnt receptor signaling pathway, calcium modulating pathway; P:planar cell polarity pathway involved in neural tube closure; C:apical part of cell; P:positive regulation of cGMP metabolic process; P:epithelial cell differentiation; P:positive regulation of transcription, DNA-dependent; F:Wnt-protein binding; P:sensory perception of smell Frizzled Frizzled/Smoothened family membrane region comp85683_c0 19.8710671626 0.0 0.0 1.0 MED_UP abnormal spindle-like microcephaly-associated protein homolog P:neuron migration; P:negative regulation of neuron differentiation; P:positive regulation of canonical Wnt receptor signaling pathway; P:developmental growth; P:maintenance of centrosome location; P:spermatogenesis; C:midbody; P:positive regulation of neuroblast proliferation; P:oogenesis; P:forebrain neuroblast division; P:negative regulation of asymmetric cell division; C:spindle pole; P:cell cycle Pfam-B_6835 comp119362_c1 4.72619012482 33.1428102323 19.2048599122 0.999999975253 RP_UP low density lipoprotein receptor-related protein isoform cra_b P:camera-type eye morphogenesis; P:regulation of bone remodeling; P:response to peptide hormone stimulus; P:cell-cell signaling involved in mammary gland development; P:extracellular matrix-cell signaling; P:somatic stem cell maintenance; P:anterior/posterior pattern specification; P:positive regulation of sequence-specific DNA binding transcription factor activity; P:retina vasculature morphogenesis in camera-type eye; P:cholesterol metabolic process; P:cell migration involved in gastrulation; P:gastrulation with mouth forming second; P:regulation of apoptotic process; P:bone development; F:Wnt-protein binding; P:embryonic digit morphogenesis; F:Wnt-activated receptor activity; C:mitochondrion; P:regulation of insulin secretion involved in cellular response to glucose stimulus; P:canonical Wnt receptor signaling pathway; P:anatomical structure regression; P:positive regulation of transcription, DNA-dependent; P:osteoblast development; C:membrane; P:apoptotic process involved in patterning of blood vessels; P:branching involved in mammary gland duct morphogenesis; P:positive regulation of osteoblast proliferation Ldl_recept_b Low-density lipoprotein receptor repeat class B comp107620_c0 149.157768136 0.0 0.351645078645 1.0 MED_UP cytosolic fe-s cluster assembly factor narfl, cytosolic fe-s cluster assembly factor narfl-like, isoform cra_b, nuclear prelamin a recognition factor F:lamin binding; C:lamin filament, F:lamin binding; P:Wnt receptor signaling pathway; F:zinc ion binding; C:lamin filament; F:ligase activity; P:protein ubiquitination; F:protein kinase binding Fe_hyd_lg_C Iron only hydrogenase large subunit, TIGR02512 FeFe_hydrog_A: [FeFe] hydrogenase, Pfam-B_1176 comp60634_c0 1331.79257463 537.460140642 556.098173138 1.0 MED_UP histone deacetylase 1 isoform 6 F:sequence-specific DNA binding transcription factor activity; P:hippocampus development; P:positive regulation of proteolysis; P:positive regulation of receptor biosynthetic process; P:positive regulation of cell proliferation; P:cardiac muscle cell development; C:replication fork; P:maintenance of chromatin silencing; P:histone H4 deacetylation; C:ESC/E(Z) complex; P:positive regulation of sequence-specific DNA binding transcription factor activity; P:histone H3 deacetylation; P:negative regulation of neuron projection development; P:odontogenesis of dentin-containing tooth; F:NAD-dependent histone deacetylase activity (H3-K18 specific); P:dendrite development; C:NuRD complex; C:heterochromatin; P:regulation of sarcomere organization; P:negative regulation of sequence-specific DNA binding transcription factor activity; F:NAD-dependent histone deacetylase activity (H3-K9 specific); P:eyelid development in camera-type eye; F:RNA polymerase II repressing transcription factor binding; P:fungiform papilla formation; P:regulation of protein deacetylation; P:positive regulation of transcription from RNA polymerase II promoter; P:embryonic digit morphogenesis; F:NAD-dependent histone deacetylase activity (H3-K14 specific); C:transcription factor complex; P:negative regulation of transcription from RNA polymerase II promoter; P:positive regulation of oligodendrocyte differentiation; P:hair follicle placode formation; F:sequence-specific DNA binding; P:negative regulation of canonical Wnt receptor signaling pathway; C:Sin3 complex; F:NAD-dependent histone deacetylase activity (H4-K16 specific); P:negative regulation of apoptotic process; F:enzyme binding; P:epidermal cell differentiation; P:regulation of protein kinase B signaling cascade; F:chromatin DNA binding; P:negative regulation of cardiac muscle cell proliferation Hist_deacetyl Histone deacetylase domain comp121550_c0 157.852950184 162.957108967 57.6322846278 0.999999996662 NRP_DOWN zinc finger protein snai2 C:nuclear chromatin; P:cell migration involved in endocardial cushion formation; P:epithelial to mesenchymal transition involved in endocardial cushion formation; P:negative regulation of stem cell proliferation; P:cellular response to ionizing radiation; P:white fat cell differentiation; P:cellular response to epidermal growth factor stimulus; F:metal ion binding; P:sensory perception of sound; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; P:negative regulation of catenin import into nucleus; P:negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter; P:negative regulation of vitamin D biosynthetic process; P:negative regulation of chondrocyte differentiation; P:negative regulation of anoikis; P:epithelium development; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; P:Notch signaling pathway; P:desmosome disassembly; C:cytoplasm; P:negative regulation of keratinocyte proliferation; P:positive regulation of histone acetylation; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; P:regulation of osteoblast differentiation; F:chromatin binding; P:positive regulation of cell migration; P:regulation of chemokine production; P:pigmentation; P:negative regulation of vitamin D receptor signaling pathway; P:regulation of tight junction assembly; F:sequence-specific DNA binding; P:negative regulation of canonical Wnt receptor signaling pathway; P:negative regulation of cell adhesion involved in substrate-bound cell migration; P:palate development; P:positive regulation of fat cell differentiation; P:neural crest cell development; P:cartilage morphogenesis zf-C2H2 Zinc finger, zf-H2C2_2 Zinc-finger double domain comp77921_c0 30.352164738 0.0 0.0 1.0 MED_UP fermt2 protein C:focal adhesion; P:angiogenesis; P:cytoskeleton organization; P:integrin activation; P:regulation of cell shape; F:phosphatidylinositol-3,4,5-trisphosphate binding; P:transforming growth factor beta receptor signaling pathway; P:Wnt receptor signaling pathway; C:filamentous actin; P:substrate adhesion-dependent cell spreading; C:extrinsic to internal side of plasma membrane; P:protein localization to membrane; P:focal adhesion assembly; P:integrin-mediated signaling pathway; C:cell surface; P:cardiac muscle tissue morphogenesis; C:I band; C:stress fiber; C:lamellipodium membrane; C:intercalated disc; C:nucleus; C:cell cortex ---NA--- comp93330_c0 32.753439713 0.0 0.0 1.0 MED_UP baculoviral iap repeat-containing protein 4 C:cytosol; P:inhibition of cysteine-type endopeptidase activity involved in apoptotic process; C:protein complex; F:scaffold protein binding; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; F:protease binding; F:ubiquitin-protein ligase activity; P:protein ubiquitination; P:positive regulation of canonical Wnt receptor signaling pathway; P:negative regulation of neuron apoptotic process; C:perinuclear region of cytoplasm; C:nucleus; P:response to DNA damage stimulus zf-C3HC4_3 Zinc finger comp55952_c0 18.5731154201 0.0 0.0 1.0 MED_UP adenomatous polyposis coli protein P:positive regulation of apoptotic process; C:tight junction; P:positive regulation of epithelial cell differentiation; P:mitotic spindle assembly checkpoint; P:negative regulation of MAPK cascade; P:positive regulation of microtubule polymerization; P:somatic stem cell maintenance; P:anterior/posterior pattern specification; P:negative regulation of epithelial cell proliferation involved in prostate gland development; C:axonal growth cone; C:lamellipodium; P:positive regulation of pseudopodium assembly; C:cytosol; P:positive regulation of cell adhesion; C:kinetochore; C:cytoplasmic microtubule; P:hair follicle development; P:tight junction assembly; P:T cell differentiation in thymus; P:regulation of osteoclast differentiation; F:beta-catenin binding; P:retina development in camera-type eye; P:kidney development; P:positive regulation of cell division; P:regulation of nitrogen compound metabolic process; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; P:axonogenesis; P:axis specification; P:cytoplasmic microtubule organization; P:cellular component disassembly involved in execution phase of apoptosis; P:response to DNA damage stimulus; P:muscle cell cellular homeostasis; F:microtubule plus-end binding; C:cell-cell adherens junction; P:regulation of osteoblast differentiation; P:cell cycle arrest; P:mitotic cytokinesis; P:positive regulation of cell migration; P:dorsal/ventral pattern formation; F:protein kinase binding; F:protein kinase regulator activity; P:regulation of attachment of spindle microtubules to kinetochore; F:cadherin binding; P:negative regulation of odontogenesis; P:proximal/distal pattern formation; P:negative regulation of canonical Wnt receptor signaling pathway; C:beta-catenin destruction complex; P:negative regulation of apoptotic process; C:microtubule plus end; P:chromosome organization; C:nucleus; C:centrosome; C:ruffle membrane; P:thymus development; P:negative regulation of microtubule depolymerization; F:gamma-catenin binding; P:positive regulation of protein catabolic process; C:lateral plasma membrane ---NA--- comp108945_c1 20.3760093226 0.0 0.0 1.0 MED_UP receptor-type tyrosine-protein phosphatase o-like P:negative regulation of glomerular filtration; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; C:cell-cell junction; P:negative regulation of cell migration; P:lamellipodium assembly; C:dendritic spine; C:lamellipodium; P:negative regulation of canonical Wnt receptor signaling pathway; C:growth cone; F:transmembrane receptor protein tyrosine phosphatase activity; P:homotypic cell-cell adhesion; P:negative regulation of retinal ganglion cell axon guidance; P:protein localization to cell surface; P:negative regulation of cell proliferation; P:peptidyl-tyrosine dephosphorylation; C:lateral plasma membrane; P:slit diaphragm assembly; P:negative regulation of cell-substrate adhesion; C:axon; P:glomerular visceral epithelial cell differentiation; P:negative regulation of neuron projection development; P:monocyte chemotaxis; F:protein homodimerization activity; F:beta-catenin binding; C:integral to plasma membrane; F:Wnt-protein binding; C:apical plasma membrane Pfam-B_5451 comp108945_c2 16.7203469877 0.0 0.0 0.999999999999 MED_UP receptor-type tyrosine-protein phosphatase o P:negative regulation of glomerular filtration; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; C:cell-cell junction; P:negative regulation of cell migration; P:lamellipodium assembly; C:dendritic spine; C:lamellipodium; P:negative regulation of canonical Wnt receptor signaling pathway; C:growth cone; F:transmembrane receptor protein tyrosine phosphatase activity; P:homotypic cell-cell adhesion; P:negative regulation of retinal ganglion cell axon guidance; P:protein localization to cell surface; P:negative regulation of cell proliferation; P:peptidyl-tyrosine dephosphorylation; C:lateral plasma membrane; P:slit diaphragm assembly; P:negative regulation of cell-substrate adhesion; C:axon; P:glomerular visceral epithelial cell differentiation; P:negative regulation of neuron projection development; P:monocyte chemotaxis; F:protein homodimerization activity; F:beta-catenin binding; C:integral to plasma membrane; F:Wnt-protein binding; C:apical plasma membrane Pfam-B_5451 comp124459_c1 258.05928505 0.0 0.0 1.0 MED_UP casein kinase ii subunit alpha, casein kinase ii subunit alpha -like P:protein phosphorylation; F:ATP binding; F:protein serine/threonine kinase activity, F:protein N-terminus binding; C:protein kinase CK2 complex; P:protein phosphorylation; P:Wnt receptor signaling pathway; P:mitotic spindle checkpoint; C:PcG protein complex; F:protein serine/threonine kinase activity; P:apoptotic process; P:regulation of transcription, DNA-dependent; F:ATP binding Pkinase Protein kinase domain comp109879_c0 84.8690459092 0.0 0.351645078645 1.0 MED_UP f-box-like wd repeat-containing protein tbl1xr1 P:canonical Wnt receptor signaling pathway; P:negative regulation of transcription from RNA polymerase II promoter; P:Notch signaling pathway; F:histone binding; F:transcription corepressor activity; P:proteasomal ubiquitin-dependent protein catabolic process; P:cellular lipid metabolic process; C:transcriptional repressor complex; F:protein N-terminus binding; C:nucleolus; F:transcription regulatory region DNA binding; C:histone deacetylase complex; P:small molecule metabolic process; P:positive regulation of transcription from RNA polymerase II promoter; C:spindle microtubule; F:beta-catenin binding; P:chromatin modification WD40 WD domain comp119888_c0 49.3007866342 107.775995479 76.5871899347 0.999999518851 RP_UP low-density lipoprotein receptor-related protein 6- partial, af223365_1ldl-related protein lrp6 P:regulation of primary metabolic process; P:canonical Wnt receptor signaling pathway; P:regulation of macromolecule metabolic process; P:positive regulation of cellular process; P:cellular macromolecule metabolic process; P:regulation of cellular metabolic process; P:chordate embryonic development; P:mesenchymal cell differentiation; P:regionalization; P:negative regulation of cellular process; P:embryonic morphogenesis; P:brain development; P:axis specification; C:cell part; P:regulation of organ morphogenesis; P:heart morphogenesis; P:Wnt receptor signaling pathway involved in heart development; P:regulation of Wnt receptor signaling pathway; P:morphogenesis of an epithelium; F:protein binding, C:integral to membrane; C:membrane Ldl_recept_a Low-density lipoprotein receptor domain class A, Pfam-B_5012 comp296447_c0 25.9256958151 0.0 0.0 1.0 MED_UP chromodomain-helicase-dna-binding protein 8 isoform x1 P:chromatin modification; C:MLL1 complex; P:Wnt receptor signaling pathway; P:regulation of transcription, DNA-dependent; F:DNA binding; F:ATP binding; F:helicase activity; F:chromatin binding ---NA--- comp86471_c0 21.8824427793 0.0 0.0 1.0 MED_UP g protein-coupled receptor kinase 6 P:protein phosphorylation; P:Wnt receptor signaling pathway; F:G-protein coupled receptor kinase activity; P:termination of G-protein coupled receptor signaling pathway; F:ATP binding; C:membrane Pkinase Protein kinase domain comp127587_c1 515.138710751 0.0 1.40658031458 1.0 MED_UP phosphatase and tensin-like protein b long splice variant, phosphatidylinositol -trisphosphate 3-phosphatase and dual-specificity protein phosphatase pten P:hemopoiesis; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; P:convergent extension involved in gastrulation; F:protein tyrosine/serine/threonine phosphatase activity; P:negative regulation of cell migration; P:inositol phosphate dephosphorylation; F:PDZ domain binding; F:protein tyrosine phosphatase activity; P:regulation of protein stability; F:lipid phosphatase activity; P:blood vessel development; P:negative regulation of focal adhesion assembly; P:phosphatidylinositol dephosphorylation; P:lifelong otolith mineralization; P:negative regulation of cell proliferation; P:peptidyl-tyrosine dephosphorylation; F:magnesium ion binding; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; P:negative regulation of protein kinase B signaling cascade, P:positive regulation of excitatory postsynaptic membrane potential; F:PDZ domain binding; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; C:myelin sheath adaxonal region; F:protein kinase binding; P:negative regulation of myelination; P:canonical Wnt receptor signaling pathway; P:central nervous system neuron axonogenesis; P:locomotor rhythm; P:central nervous system myelin maintenance; P:cardiac muscle tissue development; P:endothelial cell migration; F:protein tyrosine/serine/threonine phosphatase activity; C:cytoplasm; P:rhythmic synaptic transmission; F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; P:postsynaptic density assembly; P:angiogenesis; C:Schmidt-Lanterman incisure; P:forebrain morphogenesis; P:negative regulation of apoptotic process; P:negative regulation of cell migration; P:positive regulation of cell proliferation; F:phosphatidylinositol-3-phosphatase activity; P:induction of apoptosis; P:long-term synaptic potentiation; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; F:protein serine/threonine phosphatase activity; P:protein stabilization; P:inositol phosphate dephosphorylation; P:learning or memory; P:social behavior; C:neuron projection; C:nucleus; P:dentate gyrus development; P:negative regulation of cell aging; P:activation of mitotic anaphase-promoting complex activity; F:magnesium ion binding; P:negative regulation of synaptic vesicle clustering; P:negative regulation of organ growth; P:peptidyl-tyrosine dephosphorylation; P:negative regulation of epithelial cell proliferation; P:phosphatidylinositol dephosphorylation; P:multicellular organismal response to stress; P:regulation of B cell apoptotic process; P:negative regulation of axonogenesis; P:negative regulation of protein kinase B signaling cascade; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; P:positive regulation of sequence-specific DNA binding transcription factor activity; P:negative regulation of dendritic spine morphogenesis; P:neuron-neuron synaptic transmission; P:maternal behavior; F:anaphase-promoting complex binding; P:presynaptic membrane assembly; P:negative regulation of cell size; P:negative regulation of ribosome biogenesis; P:negative regulation of focal adhesion assembly; F:protein tyrosine phosphatase activity; P:prepulse inhibition; P:regulation of myeloid cell apoptotic process; P:prostate gland growth; C:internal side of plasma membrane; P:negative regulation of excitatory postsynaptic membrane potential; P:male mating behavior; P:synapse maturation PTEN_C2 C2 domain of PTEN tumour-suppressor protein comp128809_c0 577.152167709 0.0 0.0 1.0 MED_UP dapper homolog 1 P:negative regulation of JNK cascade; P:negative regulation of Wnt receptor signaling pathway; F:protein binding; C:beta-catenin destruction complex Dapper Dapper comp128809_c1 583.217316723 0.190431584741 0.0 1.0 MED_UP dapper homolog 1 P:anatomical structure morphogenesis; P:multicellular organismal development; P:positive regulation of biological process; P:negative regulation of signal transduction; P:regulation of Wnt receptor signaling pathway; P:single-organism developmental process; P:regulation of macromolecule metabolic process Dapper Dapper comp96515_c0 17.8045310245 0.0 0.0 1.0 MED_UP trf1-interacting ankyrin-related adp-ribose polymerase P:protein polyubiquitination; P:mRNA transport; P:positive regulation of canonical Wnt receptor signaling pathway; C:Golgi membrane; F:protein binding; F:zinc ion binding; P:peptidyl-threonine phosphorylation; P:protein poly-ADP-ribosylation; C:nuclear chromosome, telomeric region; P:mitotic spindle organization; C:nuclear membrane; P:positive regulation of telomere maintenance via telomerase; P:protein transport; P:cell division; P:spindle assembly; P:negative regulation of DNA binding; F:NAD+ ADP-ribosyltransferase activity; C:nuclear pore; C:chromosome, centromeric region; P:peptidyl-serine phosphorylation; P:mitosis; P:protein auto-ADP-ribosylation; C:pericentriolar material; P:protein localization to chromosome, telomeric region; P:positive regulation of transcription from RNA polymerase II promoter; C:spindle pole Ank Ankyrin repeat comp112021_c1 30.1969781246 0.0 0.0 1.0 MED_UP achain structure of the kinase associated domain 1 from mark1 kinase P:neuron migration; P:protein phosphorylation; P:Wnt receptor signaling pathway; C:microtubule cytoskeleton; P:intracellular protein kinase cascade; F:protein serine/threonine kinase activity; P:microtubule cytoskeleton organization; F:phosphatidylinositol-4,5-bisphosphate binding; F:ATP binding; F:magnesium ion binding; F:tau-protein kinase activity; F:phosphatidylserine binding; F:phosphatidic acid binding; C:cytoplasm; C:plasma membrane ---NA--- comp112021_c0 57.8752235294 1.12754585844 0.0 1.0 MED_UP achain structure of the kinase associated domain 1 from mark1 kinase P:neuron migration; P:protein phosphorylation; P:Wnt receptor signaling pathway; C:microtubule cytoskeleton; P:intracellular protein kinase cascade; F:protein serine/threonine kinase activity; P:microtubule cytoskeleton organization; F:phosphatidylinositol-4,5-bisphosphate binding; F:ATP binding; F:protein binding; F:magnesium ion binding; F:tau-protein kinase activity; F:phosphatidylserine binding; F:phosphatidic acid binding; C:cytoplasm; C:plasma membrane ---NA--- comp179940_c0 237.886597878 0.0 0.0 1.0 MED_UP mediator of rna polymerase ii transcription subunit 10 P:Wnt receptor signaling pathway; P:regulation of transcription from RNA polymerase II promoter; P:heart development; F:RNA polymerase II transcription cofactor activity; C:mediator complex Med10 Transcription factor subunit Med10 of Mediator complex comp120594_c0 95.341405801 40.6800145664 111.886797021 1.0 RP_DOWN achain 4ank: a designed ankyrin repeat protein with four identical consensus repeats P:protein polyubiquitination; P:positive regulation of canonical Wnt receptor signaling pathway; F:NAD+ ADP-ribosyltransferase activity; C:nuclear envelope; P:protein auto-ADP-ribosylation; C:pericentriolar material; P:protein localization to chromosome, telomeric region; C:perinuclear region of cytoplasm; F:enzyme binding Ank_4 Ankyrin repeats (many copies) comp95767_c0 69.1989760706 28.5776357105 168.964798386 1.0 NRP_UP protein wnt-2b F:receptor binding; P:multicellular organismal development; P:Wnt receptor signaling pathway; C:proteinaceous extracellular matrix; C:extracellular region wnt wnt family comp111259_c0 68.6589924828 47.5153026404 159.037522286 1.0 NRP_UP protein wnt-2b F:receptor binding; P:multicellular organismal development; P:Wnt receptor signaling pathway; C:proteinaceous extracellular matrix; C:extracellular region wnt wnt family comp124303_c0 770.919743101 0.345691657283 0.351645078645 1.0 MED_UP kelch-like protein 12 P:Wnt receptor signaling pathway; C:Cul3-RING ubiquitin ligase complex; P:protein monoubiquitination; C:ER to Golgi transport vesicle; P:COPII vesicle coating Kelch_1 Kelch motif comp127573_c0 326.498895864 403.649689836 202.756507946 1.0 RP_UP PREDICTED: uncharacterized protein LOC100207765, partial, protein af-10, myeloid lymphoid or mixed-lineage leukemia (trithorax drosophila) translocated 10 P:intestinal epithelial structure maintenance; F:zinc ion binding; P:canonical Wnt receptor signaling pathway, F:zinc ion binding, F:metal ion binding; F:zinc ion binding Pfam-B_18511 comp82951_c0 18.9201623049 0.0 0.0 1.0 MED_UP tankyrase- partial P:protein polyubiquitination; F:enzyme binding; P:positive regulation of canonical Wnt receptor signaling pathway; P:protein auto-ADP-ribosylation; C:perinuclear region of cytoplasm; P:protein localization to chromosome, telomeric region; C:nuclear envelope; P:regulation of multicellular organism growth; F:NAD+ ADP-ribosyltransferase activity; C:pericentriolar material Ank Ankyrin repeat comp128602_c0 2969.96622769 0.35240094468 1.05493523593 1.0 MED_UP capr2_danre ame: full=caprin-2 ame: full=rna granule protein 140, caprin-2 isoform x2 P:positive regulation of developmental process; P:positive regulation of canonical Wnt receptor signaling pathway; P:positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; P:positive regulation of cell projection organization; P:regulation of dendrite morphogenesis, P:positive regulation of canonical Wnt receptor signaling pathway; P:positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; P:cell differentiation Pfam-B_3428 comp119829_c1 278.847945398 0.18256509998 0.423302304351 1.0 MED_UP achain catalytic and ubiqutin-associated domains of mark1par-1, serine threonine-protein kinase mark1 isoform x14, map microtubule affinity-regulating kinase 3 isoform x7, serine threonine-protein kinase mark1, serine threonine-protein kinase mark1 isoform x13 P:protein phosphorylation; F:protein serine/threonine kinase activity; F:phospholipid binding; F:ATP binding; C:plasma membrane, P:protein phosphorylation; P:intracellular protein kinase cascade; F:protein serine/threonine kinase activity; F:phosphatidylinositol-4,5-bisphosphate binding; F:ATP binding; F:magnesium ion binding; F:phosphatidylserine binding; F:phosphatidic acid binding; C:plasma membrane, C:plasma membrane; F:phosphatidylserine binding; F:ATP binding; F:magnesium ion binding; P:intracellular protein kinase cascade; F:phosphatidic acid binding; F:protein serine/threonine kinase activity; F:phosphatidylinositol-4,5-bisphosphate binding, C:plasma membrane; P:protein phosphorylation; F:ATP binding; F:protein serine/threonine kinase activity, P:neuron migration; P:protein phosphorylation; P:Wnt receptor signaling pathway; C:microtubule cytoskeleton; P:intracellular protein kinase cascade; F:protein serine/threonine kinase activity; P:microtubule cytoskeleton organization; F:phosphatidylinositol-4,5-bisphosphate binding; F:ATP binding; F:magnesium ion binding; F:tau-protein kinase activity; F:phosphatidylserine binding; F:phosphatidic acid binding; C:cytoplasm; C:plasma membrane Pfam-B_16841, Pkinase Protein kinase domain comp109593_c0 62.9845645662 24.6776469696 191.434802205 1.0 NRP_UP protein wnt-5a-like isoform x1 F:receptor binding; P:multicellular organismal development; P:Wnt receptor signaling pathway; C:proteinaceous extracellular matrix; C:extracellular region wnt wnt family comp102203_c1 94.7020492375 0.0 0.0 1.0 MED_UP adp-ribosylation factor-like protein 6 C:cytoplasm; P:Wnt receptor signaling pathway; P:cilium assembly; F:GTP binding; P:fat cell differentiation; C:membrane; P:small GTPase mediated signal transduction Arf ADP-ribosylation factor family comp127239_c1 865.083149022 0.0 0.0 1.0 MED_UP presenilin-1-like isoform x1, pinin isoform x1, psen1 protein C:membrane raft; P:canonical Wnt receptor signaling pathway; C:dendritic shaft; P:beta-amyloid formation; P:Notch signaling pathway; C:Golgi membrane; C:neuromuscular junction; P:positive regulation of catalytic activity; P:somite development; C:growth cone; P:smooth endoplasmic reticulum calcium ion homeostasis; C:ciliary rootlet; F:cadherin binding; P:calcium ion transport; C:mitochondrial inner membrane; C:endoplasmic reticulum membrane; C:lysosomal membrane; C:cell surface; P:membrane protein ectodomain proteolysis; P:melanocyte differentiation; P:lymphangiogenesis; P:brain development; P:protein processing; P:Notch receptor processing; C:neuronal cell body; C:axon; F:aspartic-type endopeptidase activity; P:swimming behavior; C:Z disc; C:perinuclear region of cytoplasm; C:integral to plasma membrane; C:nucleus; C:apical plasma membrane; P:intracellular signal transduction; C:cell cortex, C:catalytic step 2 spliceosome; C:cytoplasm; C:nuclear speck Presenilin Presenilin comp119795_c0 269.65428513 200.301437694 66.86445902 1.0 MED_UP zinc finger protein snai2 C:nuclear chromatin; P:cell migration involved in endocardial cushion formation; P:epithelial to mesenchymal transition involved in endocardial cushion formation; P:negative regulation of stem cell proliferation; P:cellular response to ionizing radiation; P:white fat cell differentiation; P:cellular response to epidermal growth factor stimulus; F:metal ion binding; P:sensory perception of sound; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; P:negative regulation of catenin import into nucleus; P:negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter; P:negative regulation of vitamin D biosynthetic process; P:negative regulation of chondrocyte differentiation; P:negative regulation of anoikis; P:epithelium development; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; P:Notch signaling pathway; P:desmosome disassembly; C:cytoplasm; P:negative regulation of keratinocyte proliferation; P:positive regulation of histone acetylation; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; P:regulation of osteoblast differentiation; F:chromatin binding; P:positive regulation of cell migration; P:regulation of chemokine production; P:pigmentation; P:negative regulation of vitamin D receptor signaling pathway; P:regulation of tight junction assembly; F:sequence-specific DNA binding; P:negative regulation of canonical Wnt receptor signaling pathway; P:negative regulation of cell adhesion involved in substrate-bound cell migration; P:palate development; P:positive regulation of fat cell differentiation; P:neural crest cell development; P:cartilage morphogenesis zf-C2H2 Zinc finger comp121776_c0 177.238567433 0.0 0.0 1.0 MED_UP methyl- -binding domain protein 2 isoform x1 P:negative regulation of transcription from RNA polymerase II promoter; P:regulation of cell proliferation; F:siRNA binding; C:cytoplasm; C:heterochromatin; P:cellular protein complex assembly; C:histone deacetylase complex; F:methyl-CpG binding; F:C2H2 zinc finger domain binding; F:chromatin binding; P:maternal behavior; P:positive regulation of Wnt receptor signaling pathway; F:mRNA binding ---NA--- comp121776_c1 298.140114626 0.0 0.0 1.0 MED_UP methyl- -binding domain protein 2 isoform x1 P:negative regulation of transcription from RNA polymerase II promoter; P:regulation of cell proliferation; F:siRNA binding; C:cytoplasm; C:heterochromatin; P:cellular protein complex assembly; C:histone deacetylase complex; F:methyl-CpG binding; F:C2H2 zinc finger domain binding; F:chromatin binding; P:maternal behavior; P:positive regulation of Wnt receptor signaling pathway; F:mRNA binding ---NA--- comp127720_c0 61.7178095628 160.077719781 104.904047 0.999999972209 RP_UP tcf hmg-box transcription factor P:Wnt receptor signaling pathway HMG_box HMG (high mobility group) box comp128381_c0 1601.64640131 0.197140872139 1.12659246164 1.0 MED_UP cullin-3- partial, cullin-3 isoform 1 P:protein polyubiquitination; P:cyclin catabolic process; F:POZ domain binding; P:stem cell division; P:gastrulation; P:Wnt receptor signaling pathway; P:positive regulation of cytokinesis; P:protein monoubiquitination; P:negative regulation of Rho protein signal transduction; P:embryonic cleavage; C:Golgi apparatus; P:integrin-mediated signaling pathway; P:intrinsic apoptotic signaling pathway; P:cell cycle arrest; P:positive regulation of cell proliferation; F:ubiquitin-protein ligase activity; F:ubiquitin protein ligase binding; P:trophectodermal cellular morphogenesis; C:polar microtubule; P:COPII vesicle coating; P:G1/S transition of mitotic cell cycle; P:stress fiber assembly; P:mitotic anaphase; F:cyclin binding; C:nucleus; P:cell migration; C:Cul3-RING ubiquitin ligase complex, P:protein polyubiquitination; P:cyclin catabolic process; F:POZ domain binding; P:stem cell division; P:gastrulation; P:Wnt receptor signaling pathway; P:positive regulation of cytokinesis; P:protein monoubiquitination; P:negative regulation of Rho protein signal transduction; P:embryonic cleavage; C:Golgi apparatus; P:integrin-mediated signaling pathway; F:ubiquitin-protein ligase activity; F:ubiquitin protein ligase binding; P:trophectodermal cellular morphogenesis; C:polar microtubule; P:COPII vesicle coating; P:stress fiber assembly; F:cyclin binding; C:nucleus; P:cell migration; C:Cul3-RING ubiquitin ligase complex Cullin Cullin family, Cullin_Nedd8 Cullin protein neddylation domain comp109158_c0 260.444950917 0.0 0.351645078645 1.0 MED_UP f-box wd repeat-containing protein 11-like isoform x2 P:protein polyubiquitination; P:Wnt receptor signaling pathway; P:protein destabilization; P:negative regulation of transcription, DNA-dependent; F:protein dimerization activity; C:cytosol; C:SCF ubiquitin ligase complex; F:ubiquitin-protein ligase activity; C:centrosome; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; P:positive regulation of transcription, DNA-dependent; P:protein dephosphorylation; P:positive regulation of circadian rhythm; P:negative regulation of NF-kappaB import into nucleus; C:nucleus; P:positive regulation of proteolysis; P:cell cycle WD40 WD domain comp91855_c0 16.3518954824 0.0 0.0 0.999999999998 MED_UP adenomatous polyposis coli protein isoform 1 P:protein complex assembly; P:regulation of cell migration; P:regulation of protein metabolic process; C:growth cone; P:negative regulation of epithelial cell proliferation; C:cell leading edge; P:cell division; P:skin development; P:regulation of microtubule polymerization or depolymerization; P:regulation of cellular component biogenesis; P:negative regulation of organelle organization; P:anatomical structure morphogenesis; P:positive regulation of cell differentiation; P:regulation of apoptotic process; C:cell-cell junction; P:negative regulation of Wnt receptor signaling pathway; P:metaphase/anaphase transition of mitotic cell cycle; P:regulation of epithelial cell differentiation; P:canonical Wnt receptor signaling pathway; P:regulation of biological quality; C:microtubule; P:negative regulation of cell cycle; P:regionalization; P:leukocyte differentiation; C:cytoplasmic part; P:stem cell maintenance; C:cell projection membrane; P:cell projection organization; P:urogenital system development; P:positive regulation of cellular component organization; F:microtubule binding ---NA--- comp95955_c0 4631.72068875 0.450048122309 4.85203005155 1.0 MED_UP translation initiation factor if-2-like P:embryonic eye morphogenesis; P:neural tube formation; P:establishment of planar polarity; P:positive regulation of Wnt receptor signaling pathway, calcium modulating pathway; P:cell morphogenesis; P:muscle cell migration; P:neuron migration; P:cell differentiation; P:left/right pattern formation; P:cell migration in hindbrain; P:Wnt receptor signaling pathway, planar cell polarity pathway; P:cell migration involved in gastrulation; P:eye development; P:canonical Wnt receptor signaling pathway; P:Wnt receptor signaling pathway; C:integral to membrane; P:establishment of cell polarity; C:membrane; P:convergent extension involved in gastrulation; P:convergent extension; P:cloaca development; P:neural plate morphogenesis; P:multicellular organismal development; P:establishment of mitotic spindle orientation; P:gastrulation; P:nervous system development; P:somitogenesis; P:cilium organization; P:axis elongation; P:post-anal tail morphogenesis; P:regulation of Wnt receptor signaling pathway; F:protein binding; P:notochord development; C:plasma membrane; P:striated muscle cell development ---NA--- comp126305_c0 752.696282519 0.0 0.0 1.0 MED_UP lim domain-binding protein 1 isoform x2 C:cell-cell junction; P:Wnt receptor signaling pathway; P:negative regulation of erythrocyte differentiation; P:cerebellar Purkinje cell differentiation; F:transcription cofactor activity; P:histone H3-K4 acetylation; F:protein self-association; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; P:positive regulation of hemoglobin biosynthetic process; P:gastrulation with mouth forming second; P:hair follicle development; P:negative regulation of transcription, DNA-dependent; P:regulation of DNA-dependent transcription, elongation; P:head development; P:somatic stem cell maintenance; F:LIM domain binding; P:cellular component assembly; C:transcription factor complex; P:epithelial structure maintenance; P:positive regulation of cell adhesion; F:RNA polymerase II activating transcription factor binding; P:anterior/posterior axis specification; C:nuclear chromatin; P:positive regulation of transcription from RNA polymerase II promoter; F:enhancer sequence-specific DNA binding; F:protein homodimerization activity; F:chromatin binding; F:enzyme binding, C:cell-cell junction; P:Wnt receptor signaling pathway; P:negative regulation of erythrocyte differentiation; P:cerebellar Purkinje cell differentiation; F:transcription cofactor activity; P:histone H3-K4 acetylation; F:protein self-association; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; P:positive regulation of hemoglobin biosynthetic process; P:gastrulation with mouth forming second; P:hair follicle development; P:negative regulation of transcription, DNA-dependent; P:head development; P:regulation of DNA-dependent transcription, elongation; P:somatic stem cell maintenance; F:LIM domain binding; P:cellular component assembly; C:transcription factor complex; P:epithelial structure maintenance; P:positive regulation of cell adhesion; F:RNA polymerase II activating transcription factor binding; P:anterior/posterior axis specification; C:nuclear chromatin; P:positive regulation of transcription from RNA polymerase II promoter; F:enhancer sequence-specific DNA binding; F:protein homodimerization activity; F:chromatin binding; F:enzyme binding LIM_bind LIM-domain binding protein comp83770_c0 89.0830679442 0.0 0.0 1.0 MED_UP transcription factor 7-like 1-a-like isoform x2 P:Wnt receptor signaling pathway CTNNB1_binding N-terminal CTNNB1 binding comp127951_c0 300.051020165 158.929428576 199.920405042 0.999999089996 MED_UP intraflagellar transport protein 80 homolog, intraflagellar transport protein 80 homolog isoform x3 P:positive regulation of smoothened signaling pathway; P:chondrocyte differentiation; C:cilium basal body; C:centrosome; P:bone morphogenesis; P:osteoblast differentiation; P:cilium assembly; P:negative regulation of non-canonical Wnt receptor signaling pathway; C:cytoplasm Pfam-B_5803 comp118665_c1 388.1568704 0.0 0.0 1.0 MED_UP ell-associated factor 2-like P:convergent extension involved in organogenesis; P:regulation of transcription, DNA-dependent; P:pancreas development; P:heart development; P:regulation of Wnt receptor signaling pathway; P:cell migration involved in gastrulation; P:convergent extension involved in axis elongation; P:muscle cell migration; C:ELL-EAF complex EAF RNA polymerase II transcription elongation factor comp118665_c0 136.731664826 0.0 0.0 1.0 MED_UP ell-associated factor 2 P:cell migration involved in gastrulation; P:regulation of Wnt receptor signaling pathway; C:ELL-EAF complex; P:pancreas development; P:heart development; P:regulation of transcription, DNA-dependent; P:muscle cell migration; P:convergent extension involved in organogenesis; P:convergent extension involved in axis elongation; P:negative regulation of cell growth; P:negative regulation of epithelial cell proliferation involved in prostate gland development; C:nucleoplasm; P:positive regulation of transcription, DNA-dependent; C:nucleus ---NA--- comp230137_c0 67.0161979818 0.0 0.351645078645 1.0 MED_UP histone deacetylase partial F:sequence-specific DNA binding transcription factor activity; P:hippocampus development; P:positive regulation of proteolysis; P:positive regulation of receptor biosynthetic process; P:positive regulation of cell proliferation; P:cardiac muscle cell development; C:replication fork; P:maintenance of chromatin silencing; C:ESC/E(Z) complex; P:positive regulation of sequence-specific DNA binding transcription factor activity; P:negative regulation of neuron projection development; P:odontogenesis of dentin-containing tooth; F:NAD-dependent histone deacetylase activity (H3-K18 specific); P:dendrite development; C:NuRD complex; C:heterochromatin; P:regulation of sarcomere organization; P:negative regulation of sequence-specific DNA binding transcription factor activity; F:NAD-dependent histone deacetylase activity (H3-K9 specific); P:negative regulation of intrinsic apoptotic signaling pathway; P:eyelid development in camera-type eye; F:RNA polymerase II repressing transcription factor binding; P:fungiform papilla formation; P:cellular response to heat; P:regulation of protein deacetylation; P:positive regulation of transcription from RNA polymerase II promoter; P:histone deacetylation; P:response to cocaine; P:embryonic digit morphogenesis; F:NAD-dependent histone deacetylase activity (H3-K14 specific); C:transcription factor complex; P:negative regulation of transcription from RNA polymerase II promoter; P:positive regulation of oligodendrocyte differentiation; P:hair follicle placode formation; F:core promoter binding; F:sequence-specific DNA binding; P:negative regulation of canonical Wnt receptor signaling pathway; C:Sin3 complex; P:response to drug; F:NAD-dependent histone deacetylase activity (H4-K16 specific); P:negative regulation of apoptotic process; F:enzyme binding; P:epidermal cell differentiation; P:regulation of protein kinase B signaling cascade; F:chromatin DNA binding; P:negative regulation of cardiac muscle cell proliferation; F:heat shock protein binding ---NA--- comp98990_c0 47.1208410996 0.0 0.0 1.0 MED_UP achain crystal structure of the phosphotyrosine binding domain of mouse disabled 2 :implications for reeling signaling P:negative regulation of transcription, DNA-dependent; P:positive regulation of early endosome to late endosome transport; P:positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway; C:apical plasma membrane; P:in utero embryonic development; F:AP-2 adaptor complex binding; F:protein C-terminus binding; P:positive regulation of integrin-mediated signaling pathway; F:clathrin binding; C:clathrin coat of coated pit; P:negative regulation of protein binding; P:positive regulation of endocytosis; F:integrin binding; P:positive regulation of transforming growth factor beta receptor signaling pathway; P:positive regulation of receptor recycling; P:negative regulation of androgen receptor signaling pathway; P:positive regulation of transcription elongation from RNA polymerase II promoter; P:myeloid cell differentiation; P:clathrin coat assembly; P:endoderm development; P:excretion; C:transforming growth factor beta receptor homodimeric complex; P:pinocytosis; P:activation of JUN kinase activity; P:positive regulation of cell migration; P:positive regulation of transcription, DNA-dependent; P:positive regulation of SMAD protein import into nucleus; P:positive regulation of substrate adhesion-dependent cell spreading; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; P:negative regulation of canonical Wnt receptor signaling pathway; F:phosphatidylinositol-4,5-bisphosphate binding; C:nucleus; F:SMAD binding PID Phosphotyrosine interaction domain (PTB/PID) comp95736_c1 175.493607112 0.0 0.0 1.0 MED_UP frizzled-2 precursor P:Wnt receptor signaling pathway, calcium modulating pathway; P:elevation of cytosolic calcium ion concentration; P:regulation of transcription from RNA polymerase II promoter; P:sensory perception of smell; P:convergent extension involved in gastrulation; C:neuron projection membrane; P:positive regulation of cGMP metabolic process; P:gonad development; P:muscular septum morphogenesis; P:positive regulation of sequence-specific DNA binding transcription factor activity; P:brain development; P:cilium assembly; P:membranous septum morphogenesis; F:G-protein coupled receptor activity; P:heart looping; P:G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; P:planar cell polarity pathway involved in neural tube closure; P:cell migration; P:cochlea morphogenesis; P:axonogenesis; P:outflow tract morphogenesis; C:cytoplasm; F:Wnt-protein binding; P:endocrine pancreas development; F:Wnt-activated receptor activity; C:integral to membrane; P:canonical Wnt receptor signaling pathway; P:hard palate development; P:sensory epithelium regeneration; P:inner ear receptor cell development; P:cell-cell signaling; F:protein heterodimerization activity; P:epithelial cell differentiation; P:positive regulation of transcription, DNA-dependent; F:PDZ domain binding; C:apical part of cell; P:vasculature development; P:non-canonical Wnt receptor signaling pathway involved in heart development; P:heart jogging Frizzled Frizzled/Smoothened family membrane region comp48849_c0 26.2283799432 0.0 0.0 1.0 MED_UP axin-1 isoform x3 P:embryonic eye morphogenesis; P:optic placode formation; F:signal transducer activity; F:protein homodimerization activity; P:cellular response to organic cyclic compound; C:postsynaptic density; P:forebrain anterior/posterior pattern specification; P:dorsal/ventral axis specification; P:regulation of catenin import into nucleus; C:cytoplasmic microtubule; F:beta-catenin binding; P:embryonic skeletal joint morphogenesis; P:canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation; P:muscle cell development; P:fin regeneration; P:cytoplasmic microtubule organization; C:cytoplasmic membrane-bounded vesicle; C:plasma membrane; P:axial mesoderm formation; F:armadillo repeat domain binding; P:cell death; P:activation of JUN kinase activity; F:protein kinase binding; P:negative regulation of fat cell differentiation; P:olfactory placode formation; P:positive regulation of JNK cascade; P:Wnt receptor signaling pathway involved in forebrain neuron fate commitment; P:negative regulation of canonical Wnt receptor signaling pathway; C:beta-catenin destruction complex; F:GTPase activator activity; P:determination of left/right symmetry; P:Wnt receptor signaling pathway involved in somitogenesis; C:cell cortex; P:termination of G-protein coupled receptor signaling pathway ---NA--- comp111206_c0 33.719208577 20.0705926166 116.80327693 0.999999999962 NRP_UP protein wnt-5a-like isoform x2 F:receptor binding; P:multicellular organismal development; P:Wnt receptor signaling pathway; C:proteinaceous extracellular matrix; C:extracellular region wnt wnt family comp110704_c0 134.510081693 0.0 0.0 1.0 MED_UP ubiquitin-conjugating enzyme e2 b P:protein K11-linked ubiquitination; C:nuclear chromatin; P:in utero embryonic development; P:postreplication repair; P:positive regulation of cell proliferation; C:replication fork; P:maintenance of chromatin silencing; F:ubiquitin protein ligase binding; P:sperm axoneme assembly; P:synaptonemal complex organization; P:negative regulation of cAMP-mediated signaling; P:response to hypoxia; P:maternal process involved in female pregnancy; P:response to UV; P:protein K63-linked ubiquitination; P:histone H2A ubiquitination; P:cellular response to insulin stimulus; P:chiasma assembly; C:plasma membrane; F:ubiquitin-protein ligase activity; C:cytoplasm; P:canonical Wnt receptor signaling pathway; F:ATP binding; P:proteasomal ubiquitin-dependent protein catabolic process; P:protein stabilization; P:positive regulation of reciprocal meiotic recombination; P:histone lysine demethylation; P:negative regulation of histone phosphorylation; P:protein autoubiquitination; P:response to drug; P:negative regulation of apoptotic process; C:HULC complex; P:protein monoubiquitination; P:protein K48-linked ubiquitination; C:XY body UQ_con Ubiquitin-conjugating enzyme comp119401_c0 132.329947936 0.0 0.0 1.0 MED_UP protein wnt-5a-like isoform x2 P:multicellular organismal development; C:proteinaceous extracellular matrix; F:receptor binding; P:Wnt receptor signaling pathway wnt wnt family comp102179_c0 34.0663725807 0.0 0.0 1.0 MED_UP receptor-type tyrosine-protein phosphatase o isoform 1 P:negative regulation of glomerular filtration; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; C:cell-cell junction; P:negative regulation of cell migration; P:lamellipodium assembly; C:dendritic spine; C:lamellipodium; P:negative regulation of canonical Wnt receptor signaling pathway; C:growth cone; F:transmembrane receptor protein tyrosine phosphatase activity; P:homotypic cell-cell adhesion; P:negative regulation of retinal ganglion cell axon guidance; P:protein localization to cell surface; P:negative regulation of cell proliferation; P:peptidyl-tyrosine dephosphorylation; C:lateral plasma membrane; P:slit diaphragm assembly; P:negative regulation of cell-substrate adhesion; C:axon; P:glomerular visceral epithelial cell differentiation; P:negative regulation of neuron projection development; P:monocyte chemotaxis; F:protein homodimerization activity; F:beta-catenin binding; C:integral to plasma membrane; F:Wnt-protein binding; C:apical plasma membrane Y_phosphatase Protein-tyrosine phosphatase comp103065_c0 113.03200615 4.13147964502 66.3430583148 1.0 MED_UP leukocyte cell-derived chemotaxin-2 P:negative regulation of Wnt receptor signaling pathway Peptidase_M23 Peptidase family M23 comp123377_c0 1025.84870694 14.3894908513 21.5256324275 1.0 MED_UP casein kinase ii subunit beta P:negative regulation of blood vessel endothelial cell migration; F:kinase activity; F:receptor binding; P:positive regulation of pathway-restricted SMAD protein phosphorylation; P:Wnt receptor signaling pathway; P:adiponectin-mediated signaling pathway; P:regulation of protein kinase activity; C:protein kinase CK2 complex; C:cytoplasm; F:metal ion binding; F:protein domain specific binding; P:positive regulation of activin receptor signaling pathway; F:identical protein binding; P:endothelial tube morphogenesis; F:protein kinase regulator activity; C:PcG protein complex; C:plasma membrane; F:transcription factor binding CK_II_beta Casein kinase II regulatory subunit comp213657_c0 49.4155207398 0.0 0.0 1.0 MED_UP paf1 rna polymerase ii complex homolog ( cerevisiae) isoform cra_b C:Cdc73/Paf1 complex; P:endodermal cell fate commitment; P:negative regulation of transcription from RNA polymerase II promoter; P:histone monoubiquitination; P:negative regulation of myeloid cell differentiation; P:interleukin-6-mediated signaling pathway; P:positive regulation of histone H3-K79 methylation; P:pigmentation; P:Wnt receptor signaling pathway; P:positive regulation of transcription elongation from RNA polymerase II promoter; P:heart development; P:somitogenesis; P:neural crest cell development; P:JAK-STAT cascade; P:positive regulation of histone H3-K4 methylation; F:SH2 domain binding; P:stem cell maintenance; P:histone H2B ubiquitination; P:positive regulation of transcription from RNA polymerase II promoter; P:histone H3-K4 trimethylation; P:cellular response to lipopolysaccharide; C:transcriptionally active chromatin TPR_1 Tetratricopeptide repeat comp128470_c0 2531.27856599 0.190431584741 1.21176146937 1.0 MED_UP caprin-2 isoform x2 P:positive regulation of canonical Wnt receptor signaling pathway; P:positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification; P:cell differentiation, P:positive regulation of canonical Wnt receptor signaling pathway; P:positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification Pfam-B_3428 comp128107_c3 1158.63675931 0.190431584741 0.0 1.0 MED_UP casein kinase i isoform alpha isoform x3, casein kinase i isoform alpha isoform x2, casein kinase i isoform alpha isoform x1, casein kinase i isoform alpha isoform x4 P:peptidyl-serine phosphorylation; F:protein serine/threonine kinase activity; C:nucleolus; P:heart development; F:ATP binding; C:cytoplasm, P:peptidyl-serine phosphorylation; C:microtubule organizing center; P:Wnt receptor signaling pathway; F:protein serine/threonine kinase activity; C:nucleolus; P:cell morphogenesis; C:nuclear speck; P:heart development; P:cell division; F:ATP binding; P:mitosis; C:ribonucleoprotein complex; C:condensed chromosome kinetochore; C:cytoplasm; C:mRNA cleavage and polyadenylation specificity factor complex, P:peptidyl-serine phosphorylation; C:cytosol; P:Wnt receptor signaling pathway; F:protein serine/threonine kinase activity; C:nucleolus; P:cell morphogenesis; C:nuclear speck; P:heart development; C:centrosome; P:cell division; F:ATP binding; F:protein binding; P:mitosis; C:ribonucleoprotein complex; C:condensed chromosome kinetochore; C:mRNA cleavage and polyadenylation specificity factor complex, C:cytosol; F:peptide binding; P:protein phosphorylation; P:Wnt receptor signaling pathway; F:protein serine/threonine kinase activity; F:glycoprotein binding; P:cell morphogenesis; C:nuclear speck; C:centrosome; P:cell division; F:ATP binding; F:magnesium ion binding; P:mitosis; F:phosphoprotein binding; C:ribonucleoprotein complex; C:condensed chromosome kinetochore; C:mRNA cleavage and polyadenylation specificity factor complex Pfam-B_584, PAM2 Ataxin-2 C-terminal region comp113490_c0 140.693360497 97.3969077034 12.1060555697 1.0 NRP_DOWN tetratricopeptide repeat partial, dickkopf-related protein 1-like P:negative regulation of Wnt receptor signaling pathway; P:multicellular organismal development; C:extracellular region Dickkopf_N Dickkopf N-terminal cysteine-rich region comp122252_c0 506.078603771 77.0744922451 125.698690909 1.0 MED_UP notchless protein homolog 1-like, notchless protein homolog 1 C:nucleolus; P:Notch signaling pathway; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; P:positive regulation of canonical Wnt receptor signaling pathway; P:inner cell mass cell differentiation, C:nucleolus; P:Notch signaling pathway; P:inner cell mass cell differentiation WD40 WD domain comp83736_c2 43.7172764537 0.0 0.0 1.0 MED_UP serine threonine-protein kinase lats1 isoform x3 P:sister chromatid segregation; P:positive regulation of peptidyl-serine phosphorylation; P:negative regulation of canonical Wnt receptor signaling pathway; F:protein kinase binding; P:hormone-mediated signaling pathway; P:cytoplasmic sequestering of protein; P:regulation of actin filament polymerization; F:protein serine/threonine kinase activity; F:magnesium ion binding; P:hippo signaling cascade; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; P:keratinocyte differentiation; F:ATP binding; P:G2/M transition of mitotic cell cycle; C:spindle pole Pfam-B_4365 comp110162_c0 22.0486684493 0.0 1.75470894244 0.999999999999 MED_UP a chain human tankyrase 2 - catalytic parp domain in complex with an inhibitor P:protein polyubiquitination; P:positive regulation of canonical Wnt receptor signaling pathway; C:Golgi membrane; C:nuclear chromosome, telomeric region; P:positive regulation of telomere maintenance via telomerase; F:NAD+ ADP-ribosyltransferase activity; F:metal ion binding; C:nuclear envelope; P:protein auto-ADP-ribosylation; C:pericentriolar material; P:protein localization to chromosome, telomeric region; C:perinuclear region of cytoplasm; F:enzyme binding; P:regulation of multicellular organism growth PARP Poly(ADP-ribose) polymerase catalytic domain comp110162_c2 74.2449753862 0.0 0.0 1.0 MED_UP a chain human tankyrase 2 - catalytic parp domain in complex with an inhibitor P:protein polyubiquitination; P:positive regulation of canonical Wnt receptor signaling pathway; C:Golgi membrane; C:nuclear chromosome, telomeric region; P:positive regulation of telomere maintenance via telomerase; F:NAD+ ADP-ribosyltransferase activity; F:metal ion binding; C:nuclear envelope; P:protein auto-ADP-ribosylation; C:pericentriolar material; P:protein localization to chromosome, telomeric region; C:perinuclear region of cytoplasm; F:enzyme binding; P:regulation of multicellular organism growth PARP Poly(ADP-ribose) polymerase catalytic domain comp127724_c0 550.025456839 0.0 0.827222794142 1.0 MED_UP adenomatous polyposis coli protein, adenomatous polyposis coli P:protein complex assembly; P:regulation of cell migration; P:regulation of protein metabolic process; C:growth cone; P:negative regulation of epithelial cell proliferation; C:cell leading edge; P:cell division; P:skin development; P:regulation of microtubule polymerization or depolymerization; P:regulation of cellular component biogenesis; P:negative regulation of organelle organization; P:anatomical structure morphogenesis; P:positive regulation of cell differentiation; P:regulation of apoptotic process; C:cell-cell junction; P:negative regulation of Wnt receptor signaling pathway; P:metaphase/anaphase transition of mitotic cell cycle; P:regulation of epithelial cell differentiation; P:canonical Wnt receptor signaling pathway; P:regulation of biological quality; C:microtubule; P:negative regulation of cell cycle; P:regionalization; P:leukocyte differentiation; C:cytoplasmic part; P:stem cell maintenance; C:cell projection membrane; P:cell projection organization; P:urogenital system development; P:positive regulation of cellular component organization; F:microtubule binding, P:negative regulation of cellular process; P:Wnt receptor signaling pathway; P:cell cycle process; F:protein binding; C:intracellular part EB1_binding EB-1 Binding Domain comp119236_c0 181.980147105 0.0 0.0 1.0 MED_UP bmp and activin membrane-bound inhibitor homolog P:positive regulation of protein binding; P:positive regulation of canonical Wnt receptor signaling pathway; P:regulation of cell shape; C:membrane; F:frizzled binding; C:cytoplasm; P:positive regulation of cell proliferation; P:positive regulation of catenin import into nucleus; P:positive regulation of transcription, DNA-dependent; P:positive regulation of epithelial to mesenchymal transition; P:cell migration BAMBI BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain comp48099_c0 29.8142650513 0.0 0.0 1.0 MED_UP tyrosine-protein kinase ryk- partial F:frizzled binding; P:Wnt receptor signaling pathway; F:protein tyrosine kinase activity; P:commissural neuron axon guidance; C:cytoplasm; P:protein phosphorylation; F:Wnt-activated receptor activity; P:negative chemotaxis; P:skeletal system morphogenesis; P:positive regulation of MAPK cascade; C:plasma membrane; F:Wnt-protein binding; C:nucleus; F:ATP binding; P:corpus callosum development; P:negative regulation of axon extension involved in axon guidance Pkinase_Tyr Protein tyrosine kinase comp119528_c0 130.445984593 155.903277453 348.969657091 0.999999999997 NRP_UP glioma-associated oncogene homolog 1 (zinc finger protein) gene 2 P:Wnt receptor signaling pathway; F:nucleic acid binding; P:post-anal tail morphogenesis; F:metal ion binding; P:anterior/posterior pattern specification; P:regulation of transcription, DNA-dependent; P:hindbrain development; P:notochord development; P:mesoderm formation zf-C2H2 Zinc finger comp119528_c1 119.713345928 156.488443194 353.030526549 1.0 NRP_UP glioma-associated oncogene homolog 1 (zinc finger protein) gene 2 P:Wnt receptor signaling pathway; F:nucleic acid binding; P:post-anal tail morphogenesis; F:metal ion binding; P:anterior/posterior pattern specification; P:regulation of transcription, DNA-dependent; P:hindbrain development; P:notochord development; P:mesoderm formation zf-C2H2 Zinc finger comp81935_c0 26.2103428462 0.0 0.0 1.0 MED_UP protein af-9 isoform x2 P:positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway; P:anterior/posterior pattern specification; P:negative regulation of canonical Wnt receptor signaling pathway; F:protein binding; P:transcription, DNA-dependent; P:segment specification Pfam-B_10049 comp113574_c0 153.077855884 0.0 0.0 1.0 MED_UP protein phosphatase 1a F:signal transducer activity; F:manganese ion binding; P:negative regulation of transforming growth factor beta receptor signaling pathway; F:calmodulin-dependent protein phosphatase activity; P:peptidyl-threonine dephosphorylation; P:negative regulation of SMAD protein complex assembly; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; F:magnesium ion binding; P:positive regulation of transcription, DNA-dependent; C:nucleus; P:positive regulation of Wnt receptor signaling pathway; F:R-SMAD binding PP2C Protein phosphatase 2C comp53693_c0 24.8354357724 0.0 0.0 1.0 MED_UP low quality protein: adenomatous polyposis coli protein P:positive regulation of apoptotic process; C:tight junction; P:positive regulation of epithelial cell differentiation; P:mitotic spindle assembly checkpoint; P:negative regulation of MAPK cascade; P:positive regulation of microtubule polymerization; P:somatic stem cell maintenance; P:anterior/posterior pattern specification; P:negative regulation of epithelial cell proliferation involved in prostate gland development; C:axonal growth cone; C:lamellipodium; P:positive regulation of pseudopodium assembly; P:positive regulation of cell adhesion; C:kinetochore; C:cytoplasmic microtubule; P:hair follicle development; P:T cell differentiation in thymus; P:regulation of osteoclast differentiation; F:beta-catenin binding; P:retina development in camera-type eye; P:kidney development; P:positive regulation of cell division; P:regulation of nitrogen compound metabolic process; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; P:axonogenesis; P:axis specification; P:cytoplasmic microtubule organization; P:response to DNA damage stimulus; P:muscle cell cellular homeostasis; F:microtubule plus-end binding; C:cell-cell adherens junction; P:regulation of osteoblast differentiation; P:cell cycle arrest; P:mitotic cytokinesis; P:positive regulation of cell migration; P:dorsal/ventral pattern formation; F:protein kinase binding; F:protein kinase regulator activity; P:regulation of attachment of spindle microtubules to kinetochore; P:negative regulation of odontogenesis; P:proximal/distal pattern formation; P:negative regulation of canonical Wnt receptor signaling pathway; C:beta-catenin destruction complex; P:negative regulation of apoptotic process; C:microtubule plus end; P:chromosome organization; C:nucleus; C:centrosome; C:ruffle membrane; P:thymus development; P:negative regulation of microtubule depolymerization; F:gamma-catenin binding; P:positive regulation of protein catabolic process; C:lateral plasma membrane ---NA--- comp112692_c0 282.498069771 0.0 0.0 1.0 MED_UP ras-related c3 botulinum toxin substrate 1 (rho small gtp binding protein rac1) P:positive regulation of apoptotic process; P:neurotrophin TRK receptor signaling pathway; C:extrinsic to plasma membrane; F:GTP binding; P:inflammatory response; P:regulation of cell migration; P:positive regulation of actin filament polymerization; P:dendrite morphogenesis; P:negative regulation of receptor-mediated endocytosis; P:apoptotic signaling pathway; C:trans-Golgi network; P:cell-matrix adhesion; P:axon guidance; P:engulfment of apoptotic cell; P:ruffle assembly; P:anatomical structure arrangement; P:auditory receptor cell morphogenesis; C:lamellipodium; P:T cell costimulation; C:cytosol; P:Fc-gamma receptor signaling pathway involved in phagocytosis; P:platelet activation; P:positive regulation of phosphatidylinositol 3-kinase activity; P:regulation of defense response to virus by virus; P:cochlea morphogenesis; C:phagocytic cup; P:cell migration involved in gastrulation; C:Golgi membrane; P:positive regulation of DNA replication; P:epithelial cell morphogenesis; P:positive regulation of Rho protein signal transduction; P:myoblast fusion; P:Rac protein signal transduction; P:cell-cell junction organization; P:substrate adhesion-dependent cell spreading; P:innate immune response; P:regulation of hydrogen peroxide metabolic process; P:mast cell chemotaxis; F:Rab GTPase binding; P:localization within membrane; P:viral process; P:Fc-epsilon receptor signaling pathway; C:melanosome; F:thioesterase binding; F:GTP-dependent protein binding; F:protein kinase binding; P:cell proliferation; P:bone resorption; P:hyperosmotic response; F:GTPase activity; P:regulation of respiratory burst; P:positive regulation of lamellipodium assembly; P:dopaminergic neuron differentiation; P:Wnt receptor signaling pathway, planar cell polarity pathway; P:GTP catabolic process; P:embryonic olfactory bulb interneuron precursor migration; C:ruffle membrane; P:cerebral cortex radially oriented cell migration; P:negative regulation of interleukin-23 production Ras Ras family comp102875_c0 37.9001167753 0.0 0.0 1.0 MED_UP low quality protein: mediator of rna polymerase ii transcription subunit 12 P:canonical Wnt receptor signaling pathway; P:transcription initiation from RNA polymerase II promoter; F:vitamin D receptor binding; F:thyroid hormone receptor binding; F:protein C-terminus binding; C:mediator complex; F:RNA polymerase II transcription cofactor activity; P:heart development; P:axis elongation involved in somitogenesis; P:androgen receptor signaling pathway; P:Wnt receptor signaling pathway, planar cell polarity pathway; P:stem cell maintenance; P:negative regulation of Wnt receptor signaling pathway; F:protein domain specific binding; P:neural tube closure; P:positive regulation of transcription from RNA polymerase II promoter; F:receptor activity; F:chromatin binding; F:beta-catenin binding; F:ligand-dependent nuclear receptor transcription coactivator activity Pfam-B_10084 comp101682_c0 2374.97182331 207.602695584 5263.03570659 1.0 NRP_UP leukocyte cell-derived chemotaxin-2 P:negative regulation of Wnt receptor signaling pathway Peptidase_M23 Peptidase family M23 comp109056_c0 100.251156106 251.423956916 77.2118570283 0.999999958774 RP_UP frizzled homolog 10 P:system development; P:Wnt receptor signaling pathway; P:epiboly; F:Wnt-activated receptor activity; C:cell part; C:membrane Frizzled Frizzled/Smoothened family membrane region comp82674_c0 48.3453959433 0.0 0.0 1.0 MED_UP transducin-like enhancer of split 3 (e drosophila) isoform cra_c P:Wnt receptor signaling pathway; P:regulation of transcription, DNA-dependent; P:Notch signaling pathway; P:organ morphogenesis; P:spermatogenesis; P:myeloid cell differentiation; F:protein binding; C:nucleoplasm WD40 WD domain comp80161_c0 897.556811986 0.0 0.0 1.0 MED_UP nucleoredoxin-like isoform x1 C:cytosol; P:oxidation-reduction process; F:protein-disulfide reductase activity; P:cardiovascular system development; P:negative regulation of Wnt receptor signaling pathway; P:cell differentiation; P:negative regulation of protein ubiquitination; C:nucleus Thioredoxin_8 Thioredoxin-like comp95967_c0 6177.3899271 0.450048122309 1.88891392109 1.0 MED_UP translation initiation factor if-2-like P:embryonic eye morphogenesis; P:neural tube formation; P:establishment of planar polarity; P:positive regulation of Wnt receptor signaling pathway, calcium modulating pathway; P:cell morphogenesis; P:muscle cell migration; P:neuron migration; P:cell differentiation; P:left/right pattern formation; P:cell migration in hindbrain; P:Wnt receptor signaling pathway, planar cell polarity pathway; P:cell migration involved in gastrulation; P:eye development; P:canonical Wnt receptor signaling pathway; P:Wnt receptor signaling pathway; C:integral to membrane; P:establishment of cell polarity; C:membrane; P:convergent extension involved in gastrulation; P:convergent extension; P:cloaca development; P:neural plate morphogenesis; P:multicellular organismal development; P:establishment of mitotic spindle orientation; P:gastrulation; P:nervous system development; P:somitogenesis; P:cilium organization; P:axis elongation; P:post-anal tail morphogenesis; P:regulation of Wnt receptor signaling pathway; F:protein binding; P:notochord development; C:plasma membrane; P:striated muscle cell development ---NA--- comp124421_c0 398.434134415 0.0 0.0 1.0 MED_UP presenilin-1-like isoform x1, presenilin-1 isoform x2 C:membrane raft; P:canonical Wnt receptor signaling pathway; C:dendritic shaft; P:beta-amyloid formation; P:Notch signaling pathway; C:Golgi membrane; C:neuromuscular junction; P:positive regulation of catalytic activity; P:somite development; C:growth cone; P:smooth endoplasmic reticulum calcium ion homeostasis; C:ciliary rootlet; F:cadherin binding; P:calcium ion transport; C:mitochondrial inner membrane; C:endoplasmic reticulum membrane; C:lysosomal membrane; C:cell surface; P:membrane protein ectodomain proteolysis; P:melanocyte differentiation; P:lymphangiogenesis; P:brain development; P:protein processing; P:Notch receptor processing; C:neuronal cell body; C:axon; F:aspartic-type endopeptidase activity; P:swimming behavior; C:Z disc; C:perinuclear region of cytoplasm; C:integral to plasma membrane; C:nucleus; C:apical plasma membrane; P:intracellular signal transduction; C:cell cortex Presenilin Presenilin comp92989_c0 188.919702941 0.0 0.0 1.0 MED_UP no tail a P:post-anal tail morphogenesis; F:protein binding; P:Wnt receptor signaling pathway; P:somitogenesis; P:convergent extension involved in axis elongation; P:specification of organ position; P:heart looping; F:transcription regulatory region DNA binding; P:notochord cell differentiation; P:determination of left/right asymmetry in lateral mesoderm; F:sequence-specific DNA binding transcription factor activity; C:nucleus; P:regulation of BMP signaling pathway involved in heart jogging T-box T-box comp94013_c0 34.2148198378 0.0 0.0 1.0 MED_UP frizzled homolog 7a C:integral to membrane; P:brain development; F:G-protein coupled receptor activity; F:Wnt-protein binding; P:epiboly; P:canonical Wnt receptor signaling pathway; F:PDZ domain binding; C:neuron projection membrane; F:Wnt-activated receptor activity; P:vasculature development; P:axonogenesis; P:epithelial cell differentiation; P:Wnt receptor signaling pathway, calcium modulating pathway; P:cell migration involved in gastrulation; P:gonad development; C:cytoplasm; P:G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; C:apical part of cell; P:convergent extension involved in gastrulation Frizzled Frizzled/Smoothened family membrane region comp128173_c1 709.681338381 580.127794983 830.500655166 0.999999999991 NRP_UP ubiquitin carboxyl-terminal hydrolase 34- partial, ubiquitin carboxyl-terminal hydrolase 34 P:Wnt receptor signaling pathway; F:cysteine-type peptidase activity; P:cellular protein metabolic process, F:peptidase activity Pfam-B_1450 comp112801_c0 161.874549026 0.0 0.0 1.0 MED_UP ubiquitin-conjugating enzyme e2 b P:protein K11-linked ubiquitination; C:nuclear chromatin; P:in utero embryonic development; P:postreplication repair; P:positive regulation of cell proliferation; C:replication fork; P:maintenance of chromatin silencing; F:ubiquitin protein ligase binding; P:sperm axoneme assembly; P:synaptonemal complex organization; P:negative regulation of cAMP-mediated signaling; P:response to hypoxia; P:maternal process involved in female pregnancy; P:response to UV; P:protein K63-linked ubiquitination; P:histone H2A ubiquitination; P:cellular response to insulin stimulus; P:chiasma assembly; C:plasma membrane; F:ubiquitin-protein ligase activity; C:cytoplasm; P:canonical Wnt receptor signaling pathway; F:ATP binding; P:proteasomal ubiquitin-dependent protein catabolic process; P:protein stabilization; P:positive regulation of reciprocal meiotic recombination; P:histone lysine demethylation; P:negative regulation of histone phosphorylation; P:protein autoubiquitination; P:response to drug; P:negative regulation of apoptotic process; C:HULC complex; P:protein monoubiquitination; P:protein K48-linked ubiquitination; C:XY body UQ_con Ubiquitin-conjugating enzyme comp95984_c0 96.2130131664 50.9433265793 97.548596709 0.999999982524 RP_DOWN protein wnt-11 F:receptor binding; P:multicellular organismal development; P:Wnt receptor signaling pathway; C:proteinaceous extracellular matrix; C:extracellular region wnt wnt family comp115642_c0 192.058331706 0.155260072542 0.0 1.0 MED_UP transmembrane protein 237 P:cilium assembly; P:regulation of Wnt receptor signaling pathway; C:ciliary transition zone ---NA--- comp114223_c0 337.309291647 0.0 0.0 1.0 MED_UP rna polymerase-associated protein ctr9 homolog C:Cdc73/Paf1 complex; P:endodermal cell fate commitment; P:negative regulation of transcription from RNA polymerase II promoter; P:histone monoubiquitination; P:negative regulation of myeloid cell differentiation; P:interleukin-6-mediated signaling pathway; P:positive regulation of histone H3-K79 methylation; P:pigmentation; P:Wnt receptor signaling pathway; P:positive regulation of transcription elongation from RNA polymerase II promoter; P:heart development; P:somitogenesis; P:neural crest cell development; P:JAK-STAT cascade; P:positive regulation of histone H3-K4 methylation; F:SH2 domain binding; P:stem cell maintenance; P:histone H2B ubiquitination; P:positive regulation of transcription from RNA polymerase II promoter; P:histone H3-K4 trimethylation; P:cellular response to lipopolysaccharide; C:transcriptionally active chromatin TPR_11 TPR repeat comp127032_c1 168.551584463 0.0 0.70329015729 1.0 MED_UP casein kinase i isoform delta isoform 1 P:positive regulation of protein phosphorylation; P:positive regulation of canonical Wnt receptor signaling pathway; F:protein binding; P:cellular protein localization; P:circadian regulation of gene expression; P:spindle assembly; C:Golgi apparatus; C:cytosol; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; P:negative regulation of Wnt receptor signaling pathway; F:protein serine/threonine kinase activity; C:centrosome; C:perinuclear region of cytoplasm; C:spindle microtubule; C:plasma membrane; P:regulation of circadian rhythm; C:nucleus; F:ATP binding; F:tau-protein kinase activity; P:G2/M transition of mitotic cell cycle; C:ribonucleoprotein complex; P:DNA repair Pkinase Protein kinase domain comp127032_c0 741.976082649 0.0 0.0 1.0 MED_UP casein kinase i isoform delta isoform 1 P:positive regulation of protein phosphorylation; P:positive regulation of canonical Wnt receptor signaling pathway; F:protein binding; P:cellular protein localization; P:circadian regulation of gene expression; P:spindle assembly; C:Golgi apparatus; C:cytosol; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; P:negative regulation of Wnt receptor signaling pathway; F:protein serine/threonine kinase activity; C:centrosome; C:perinuclear region of cytoplasm; C:spindle microtubule; C:plasma membrane; P:regulation of circadian rhythm; C:nucleus; F:ATP binding; F:tau-protein kinase activity; P:G2/M transition of mitotic cell cycle; C:ribonucleoprotein complex; P:DNA repair Pkinase Protein kinase domain comp95991_c0 175.617066406 0.0 0.0 1.0 MED_UP no tail a P:post-anal tail morphogenesis; F:protein binding; P:Wnt receptor signaling pathway; P:somitogenesis; P:convergent extension involved in axis elongation; P:specification of organ position; P:heart looping; F:transcription regulatory region DNA binding; P:notochord cell differentiation; P:determination of left/right asymmetry in lateral mesoderm; F:sequence-specific DNA binding transcription factor activity; C:nucleus; P:regulation of BMP signaling pathway involved in heart jogging T-box T-box comp330756_c0 27.6497159183 0.0 0.0 1.0 MED_UP lymphoid enhancer-binding factor 1-like isoform x3 P:embryonic limb morphogenesis; P:fin morphogenesis; P:regulation of striated muscle tissue development; P:negative regulation of interleukin-4 production; P:intracellular estrogen receptor signaling pathway; P:eye pigmentation; P:formation of radial glial scaffolds; P:forebrain neuron differentiation; P:negative regulation of apoptotic process in bone marrow; P:positive regulation of neurogenesis; P:positive regulation of cell proliferation in bone marrow; P:caudal fin development; P:forebrain neuroblast division; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; F:beta-catenin binding; P:epithelial to mesenchymal transition; P:B cell proliferation; P:negative regulation of interleukin-5 production; P:fin regeneration; P:BMP signaling pathway; P:pectoral fin development; P:osteoblast differentiation; C:cytoplasm; P:apoptotic process involved in morphogenesis; P:posterior lateral line neuromast deposition; P:face morphogenesis; P:dentate gyrus development; F:armadillo repeat domain binding; C:transcription factor complex; P:neutrophil differentiation; P:canonical Wnt receptor signaling pathway; P:odontoblast differentiation; F:chromatin binding; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; P:patterning of blood vessels; P:trachea gland development; P:regulation of cell-cell adhesion; P:negative regulation of interleukin-13 production; P:somitogenesis; P:regulation of retinoic acid biosynthetic process; P:muscle fiber development; F:sequence-specific DNA binding; F:DNA binding, bending; P:positive regulation of gene expression; P:alpha-beta T cell differentiation; F:enhancer binding; P:mammary gland development; P:sprouting angiogenesis; P:paraxial mesoderm formation; P:neural crest cell migration; F:gamma-catenin binding; P:forebrain radial glial cell differentiation; F:estrogen receptor binding; P:hypothalamus cell differentiation; P:regulation of cell proliferation involved in tissue homeostasis; P:induction of apoptosis CTNNB1_binding N-terminal CTNNB1 binding comp128908_c0 278.609738718 0.18256509998 0.774947382996 1.0 MED_UP ubr5 protein P:progesterone receptor signaling pathway; P:positive regulation of protein import into nucleus, translocation; P:positive regulation of canonical Wnt receptor signaling pathway; F:zinc ion binding; F:ubiquitin-ubiquitin ligase activity; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; P:cell proliferation; F:ubiquitin binding; C:cytoplasm; P:negative regulation of histone H2A K63-linked ubiquitination; P:positive regulation of catenin import into nucleus; F:RNA binding; C:nucleus; P:negative regulation of double-strand break repair HECT HECT-domain (ubiquitin-transferase) comp128908_c1 354.531450965 0.0 0.0 1.0 MED_UP e3 ubiquitin-protein ligase ubr5, ubr5 protein P:progesterone receptor signaling pathway; P:positive regulation of protein import into nucleus, translocation; P:positive regulation of canonical Wnt receptor signaling pathway; F:zinc ion binding; F:ubiquitin-ubiquitin ligase activity; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; P:cell proliferation; F:ubiquitin binding; C:cytoplasm; P:negative regulation of histone H2A K63-linked ubiquitination; P:positive regulation of catenin import into nucleus; F:RNA binding; C:nucleus; P:negative regulation of double-strand break repair, P:progesterone receptor signaling pathway; P:positive regulation of protein import into nucleus, translocation; P:positive regulation of canonical Wnt receptor signaling pathway; F:zinc ion binding; F:ubiquitin-ubiquitin ligase activity; F:ubiquitin binding; P:negative regulation of histone H2A K63-linked ubiquitination; P:positive regulation of catenin import into nucleus; F:RNA binding; C:nucleus; P:negative regulation of double-strand break repair HECT HECT-domain (ubiquitin-transferase) comp83713_c0 141.542301428 0.0 0.0 1.0 MED_UP dna damage-binding protein 1 P:proteasomal ubiquitin-dependent protein catabolic process; P:nucleotide-excision repair, DNA damage removal; P:cell cycle checkpoint; P:Wnt receptor signaling pathway; F:damaged DNA binding; P:modulation by virus of host morphology or physiology; C:Cul4A-RING ubiquitin ligase complex; C:Cul4B-RING ubiquitin ligase complex; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; F:protein binding; C:nucleoplasm; C:cytoplasm CPSF_A CPSF A subunit region comp101902_c2 32.5275116357 0.0 0.403920489791 1.0 MED_UP adenomatous polyposis coli protein P:positive regulation of apoptotic process; C:tight junction; P:positive regulation of epithelial cell differentiation; P:mitotic spindle assembly checkpoint; P:negative regulation of MAPK cascade; P:positive regulation of microtubule polymerization; P:somatic stem cell maintenance; P:anterior/posterior pattern specification; P:negative regulation of epithelial cell proliferation involved in prostate gland development; C:axonal growth cone; C:lamellipodium; P:positive regulation of pseudopodium assembly; P:positive regulation of cell adhesion; C:kinetochore; C:cytoplasmic microtubule; P:hair follicle development; P:T cell differentiation in thymus; P:regulation of osteoclast differentiation; F:beta-catenin binding; P:retina development in camera-type eye; P:kidney development; P:positive regulation of cell division; P:regulation of nitrogen compound metabolic process; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; P:axonogenesis; P:axis specification; P:cytoplasmic microtubule organization; P:response to DNA damage stimulus; P:muscle cell cellular homeostasis; F:microtubule plus-end binding; C:cell-cell adherens junction; P:regulation of osteoblast differentiation; P:cell cycle arrest; P:mitotic cytokinesis; P:positive regulation of cell migration; P:dorsal/ventral pattern formation; F:protein kinase binding; F:protein kinase regulator activity; P:regulation of attachment of spindle microtubules to kinetochore; P:negative regulation of odontogenesis; P:proximal/distal pattern formation; P:negative regulation of canonical Wnt receptor signaling pathway; C:beta-catenin destruction complex; P:negative regulation of apoptotic process; C:microtubule plus end; P:chromosome organization; C:nucleus; C:centrosome; C:ruffle membrane; P:thymus development; P:negative regulation of microtubule depolymerization; F:gamma-catenin binding; P:positive regulation of protein catabolic process; C:lateral plasma membrane ---NA--- comp126629_c0 1078.51430858 0.0 0.70329015729 1.0 MED_UP integral membrane protein gpr177 precursor, protein wntless homolog isoform x2 F:Wnt-protein binding; P:Wnt receptor signaling pathway MIG-14_Wnt-bd Wnt-binding factor required for Wnt secretion comp94185_c0 18.9630147783 0.0 0.0 1.0 MED_UP ubr5_mouse ame: full=e3 ubiquitin-protein ligase ubr5 ame: full=e3 ubiquitin-protein hect domain-containing 1 ame: full=hyperplastic discs protein homolog P:progesterone receptor signaling pathway; P:positive regulation of protein import into nucleus, translocation; P:positive regulation of canonical Wnt receptor signaling pathway; F:zinc ion binding; F:ubiquitin-ubiquitin ligase activity; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; F:ubiquitin binding; C:cytoplasm; P:negative regulation of histone H2A K63-linked ubiquitination; P:positive regulation of catenin import into nucleus; F:RNA binding; C:nucleus; P:negative regulation of double-strand break repair Pfam-B_18259 comp128939_c0 1241.72670436 718.039044625 747.019908568 0.999999999751 MED_UP metalloproteinase inhibitor 4, rna polymerase-associated protein leo1-like ["C:Cdc73/Paf1 complex; P:endodermal cell fate commitment; P:histone monoubiquitination; P:negative regulation of myeloid cell differentiation; P:Wnt receptor signaling pathway; P:positive regulation of mRNA 3'-end processing; P:positive regulation of transcription elongation from RNA polymerase II promoter; C:nucleolus; P:stem cell maintenance; P:histone H2B ubiquitination; P:positive regulation of transcription from RNA polymerase II promoter; P:mRNA polyadenylation"] TIMP Tissue inhibitor of metalloproteinase, Leo1 Leo1-like protein comp107456_c1 22.4524763541 0.0 0.0 1.0 MED_UP adenomatous polyposis coli partial C:tight junction; P:positive regulation of epithelial cell differentiation; P:mitotic spindle assembly checkpoint; P:negative regulation of MAPK cascade; P:canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process; P:positive regulation of microtubule polymerization; P:somatic stem cell maintenance; P:anterior/posterior pattern specification; P:negative regulation of epithelial cell proliferation involved in prostate gland development; C:axonal growth cone; C:lamellipodium; P:positive regulation of pseudopodium assembly; C:cytosol; P:positive regulation of cell adhesion; C:kinetochore; C:cytoplasmic microtubule; P:hair follicle development; P:tight junction assembly; P:T cell differentiation in thymus; P:regulation of osteoclast differentiation; P:canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process; F:beta-catenin binding; P:retina development in camera-type eye; P:kidney development; P:establishment or maintenance of cell polarity; P:positive regulation of cell division; F:protease binding; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; P:axonogenesis; P:axis specification; C:Scrib-APC-beta-catenin complex; P:cytoplasmic microtubule organization; P:cellular component disassembly involved in execution phase of apoptosis; P:response to DNA damage stimulus; P:muscle cell cellular homeostasis; F:protein complex binding; F:microtubule plus-end binding; C:cell-cell adherens junction; P:regulation of osteoblast differentiation; P:cell cycle arrest; P:mitotic cytokinesis; C:cell body fiber; P:positive regulation of cell migration; P:dorsal/ventral pattern formation; C:synapse; F:protein kinase binding; F:protein kinase regulator activity; P:regulation of attachment of spindle microtubules to kinetochore; C:dendrite; C:nuclear membrane; F:cadherin binding; P:negative regulation of odontogenesis; P:proximal/distal pattern formation; P:negative regulation of canonical Wnt receptor signaling pathway; C:beta-catenin destruction complex; C:neuron projection terminus; C:microtubule plus end; P:chromosome organization; P:regulation of glutamate metabolic process; C:centrosome; C:neuronal cell body; C:ruffle membrane; C:cell cortex; P:thymus development; P:negative regulation of microtubule depolymerization; F:gamma-catenin binding; P:positive regulation of protein catabolic process; C:lateral plasma membrane Arm Armadillo/beta-catenin-like repeat comp110198_c0 50.7431564764 0.0 0.0 1.0 MED_UP receptor-type tyrosine-protein phosphatase o isoform x2 P:negative regulation of glomerular filtration; P:axon guidance; P:lamellipodium assembly; C:dendritic spine; F:protein tyrosine phosphatase activity; P:negative regulation of canonical Wnt receptor signaling pathway; C:integral to membrane; P:peptidyl-tyrosine dephosphorylation; C:lateral plasma membrane; P:slit diaphragm assembly; P:glomerular visceral epithelial cell differentiation; P:monocyte chemotaxis; F:protein homodimerization activity; F:Wnt-protein binding; C:apical plasma membrane fn3 Fibronectin type III domain comp105488_c1 39.6453963818 0.0 0.0 1.0 MED_UP beta interacting protein 1 F:beta-catenin binding; P:anterior/posterior pattern specification; P:negative regulation of Wnt receptor signaling pathway; P:branching involved in ureteric bud morphogenesis; C:nucleus; C:cytosol ---NA--- comp105488_c2 54.19192579 0.0 0.0 1.0 MED_UP beta interacting protein 1 F:beta-catenin binding; P:anterior/posterior pattern specification; P:negative regulation of Wnt receptor signaling pathway; P:branching involved in ureteric bud morphogenesis; C:nucleus; C:cytosol ---NA--- comp119769_c1 48.4478068623 0.0 0.0 1.0 MED_UP 5 -amp-activated protein kinase catalytic subunit alpha-1 P:fatty acid homeostasis; P:fatty acid biosynthetic process; P:fatty acid oxidation; P:cold acclimation; C:apical plasma membrane; P:Wnt receptor signaling pathway; P:positive regulation of cell proliferation; F:protein C-terminus binding; P:negative regulation of TOR signaling cascade; P:positive regulation of autophagy; F:metal ion binding; C:cytosol; P:cellular response to hypoxia; P:positive regulation of cholesterol biosynthetic process; P:positive regulation of glycolysis; F:kinase binding; F:tau-protein kinase activity; P:histone-serine phosphorylation; F:cAMP-dependent protein kinase activity; P:cellular response to hydrogen peroxide; P:glucose homeostasis; P:negative regulation of glucosylceramide biosynthetic process; P:regulation of energy homeostasis; P:cellular response to ethanol; P:negative regulation of lipid catabolic process; P:response to caffeine; P:cellular response to glucose starvation; P:response to activity; F:[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity; P:cell cycle arrest; F:ATP binding; F:chromatin binding; P:negative regulation of glucose import in response to insulin stimulus; P:positive regulation of gene expression; F:histone serine kinase activity; P:activation of MAPK activity; P:negative regulation of apoptotic process; P:protein heterooligomerization; F:[acetyl-CoA carboxylase] kinase activity; C:nucleus; F:AMP-activated protein kinase activity; C:AMP-activated protein kinase complex; P:regulation of circadian rhythm; P:insulin receptor signaling pathway; P:regulation of vesicle-mediated transport; P:regulation of transcription, DNA-dependent Pfam-B_7407 comp124834_c0 61.2139071403 251.691819366 87.6248071134 0.999999999283 RP_UP daple_xenla ame: full=daple-like protein ame: full=coiled-coil domain-containing protein 88c-like ame: full=dvl-associating protein with a high frequency of leucine residues-like short=xdal F:PDZ domain binding; P:dorsal/ventral axis specification; P:establishment of planar polarity; P:Wnt receptor signaling pathway; P:Wnt receptor signaling pathway, planar cell polarity pathway; P:canonical Wnt receptor signaling pathway; P:activation of JUN kinase activity Myosin_tail_1 Myosin tail comp127649_c1 439.053934073 0.0 0.0 1.0 MED_UP tax1-binding protein 3 isoform x1 F:protein C-terminus binding; P:activation of Cdc42 GTPase activity; C:cytoplasm; P:negative regulation of cell proliferation; P:negative regulation of Wnt receptor signaling pathway; P:negative regulation of protein localization to cell surface; F:beta-catenin binding; C:plasma membrane; C:nucleus PDZ PDZ domain (Also known as DHR or GLGF) comp127649_c0 187.821154508 0.0 0.0 1.0 MED_UP tax1-binding protein 3 isoform x1 F:protein C-terminus binding; P:activation of Cdc42 GTPase activity; C:cytoplasm; P:negative regulation of cell proliferation; P:negative regulation of Wnt receptor signaling pathway; P:negative regulation of protein localization to cell surface; F:beta-catenin binding; C:plasma membrane; C:nucleus PDZ PDZ domain (Also known as DHR or GLGF) comp116025_c1 217.817820714 0.0 0.0 1.0 MED_UP lysine-specific demethylase 6a-like isoform x1 P:canonical Wnt receptor signaling pathway; F:protein binding; F:histone demethylase activity (H3-K27 specific); P:heart development; P:mesodermal cell differentiation; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; P:notochord morphogenesis; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; F:metal ion binding; C:histone methyltransferase complex; P:respiratory system process; P:neural tube closure; P:histone H3-K4 methylation; P:somite rostral/caudal axis specification; P:oxidation-reduction process; P:in utero embryonic development JmjC JmjC domain comp116025_c2 66.7690007516 0.0 0.0 1.0 MED_UP lysine-specific demethylase 6a P:canonical Wnt receptor signaling pathway; F:protein binding; F:histone demethylase activity (H3-K27 specific); P:heart development; P:mesodermal cell differentiation; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; P:notochord morphogenesis; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; F:metal ion binding; C:histone methyltransferase complex; P:respiratory system process; P:neural tube closure; P:histone H3-K4 methylation; P:somite rostral/caudal axis specification; P:oxidation-reduction process; P:in utero embryonic development Pfam-B_972 comp127819_c0 511.026694292 0.155260072542 0.0 1.0 MED_UP cadherin-2 isoform 2, n- partial, cadherin type 1 preproprotein, cadherin-2-like isoform x1, achain crystal structure of mouse n-cadherin ectodomain, cadh2_crigr ame: full=cadherin-2 ame: full=neural cadherin short=n-cadherin ame: cd_antigen=cd325 P:cell migration; P:blood vessel morphogenesis; F:beta-catenin binding; P:positive regulation of muscle cell differentiation; P:positive regulation of MAPK cascade; F:calcium ion binding; C:integral to membrane; P:homophilic cell adhesion; P:calcium-dependent cell-cell adhesion; P:heterophilic cell-cell adhesion; F:phospholipid binding; C:synapse; P:adherens junction organization; C:catenin complex; P:striated muscle cell differentiation; F:protein phosphatase binding; P:negative regulation of canonical Wnt receptor signaling pathway; F:gamma-catenin binding; P:cell junction assembly; C:apical plasma membrane; F:alpha-catenin binding; C:lamellipodium; C:fascia adherens, C:integral to membrane; P:homophilic cell adhesion; F:calcium ion binding; C:plasma membrane Cadherin_C Cadherin cytoplasmic region, Cadherin Cadherin domain comp127819_c1 137.261803442 0.0 0.0 1.0 MED_UP neural partial P:cell migration; P:blood vessel morphogenesis; F:beta-catenin binding; P:positive regulation of muscle cell differentiation; P:positive regulation of MAPK cascade; F:calcium ion binding; C:integral to membrane; P:homophilic cell adhesion; P:calcium-dependent cell-cell adhesion; P:heterophilic cell-cell adhesion; F:phospholipid binding; C:synapse; P:adherens junction organization; C:catenin complex; P:striated muscle cell differentiation; F:protein phosphatase binding; P:negative regulation of canonical Wnt receptor signaling pathway; F:gamma-catenin binding; P:cell junction assembly; C:apical plasma membrane; F:alpha-catenin binding; C:lamellipodium; C:fascia adherens Cadherin Cadherin domain comp125496_c0 1137.19015533 0.0 0.403920489791 1.0 MED_UP histone deacetylase 2 P:facial nucleus development; P:positive regulation of neurogenesis; P:neuron migration; F:NAD-dependent histone deacetylase activity (H3-K9 specific); P:oligodendrocyte differentiation; P:histone H3 deacetylation; P:Wnt receptor signaling pathway; F:NAD-dependent histone deacetylase activity (H3-K14 specific); P:regulation of transcription, DNA-dependent; P:hematopoietic stem cell differentiation; P:convergent extension involved in axis elongation; P:histone H4 deacetylation; C:cytoplasm; P:negative regulation of cell proliferation; P:melanocyte differentiation; F:NAD-dependent histone deacetylase activity (H3-K18 specific); P:digestive tract development; P:rostrocaudal neural tube patterning; P:determination of dorsal identity; F:NAD-dependent histone deacetylase activity (H4-K16 specific); P:exocrine pancreas development; P:liver development; C:nucleus Hist_deacetyl Histone deacetylase domain comp333602_c0 29.5928678239 0.0 0.0 1.0 MED_UP wingless-type mmtv integration site family member partial P:multicellular organismal development; C:proteinaceous extracellular matrix; F:receptor binding; P:Wnt receptor signaling pathway wnt wnt family comp123734_c0 527.830432505 0.0 0.0 1.0 MED_UP kelch-like protein 12 P:Wnt receptor signaling pathway; C:Cul3-RING ubiquitin ligase complex; P:protein monoubiquitination; C:ER to Golgi transport vesicle; P:COPII vesicle coating Kelch_1 Kelch motif comp102689_c1 36.3654512003 0.0 0.0 1.0 MED_UP tyrosine-protein kinase transmembrane receptor ror2 P:positive regulation of canonical Wnt receptor signaling pathway; F:frizzled binding; P:negative regulation of canonical Wnt receptor signaling pathway; P:somitogenesis; P:cartilage condensation; C:integral to membrane; P:negative regulation of cell proliferation; P:Wnt receptor signaling pathway, planar cell polarity pathway; P:transmembrane receptor protein tyrosine kinase signaling pathway; P:JNK cascade; P:inner ear morphogenesis; P:protein phosphorylation; P:Wnt receptor signaling pathway, calcium modulating pathway; P:cell differentiation; F:transmembrane receptor protein tyrosine kinase activity; P:embryonic genitalia morphogenesis; P:positive regulation of transcription, DNA-dependent; F:Wnt-protein binding; P:positive regulation of cell migration; F:ATP binding ---NA--- comp108478_c0 145.997643233 0.0 0.0 1.0 MED_UP secreted frizzled-related protein 2-like, secreted frizzled-related protein 2 P:multicellular organismal development; P:Wnt receptor signaling pathway; C:extracellular region, P:Wnt receptor signaling pathway; F:protein binding; C:cell part; P:organ development; P:single-organism developmental process Fz Fz domain comp99252_c0 87.1573650119 0.0 0.0 1.0 MED_UP mgc83762 protein C:cytosol; F:RNA polymerase II transcription corepressor activity; P:Wnt receptor signaling pathway; C:transcription factor complex; P:negative regulation of transcription from RNA polymerase II promoter; P:negative regulation of anoikis; P:positive regulation of gene expression; F:transcription factor binding; F:chromatin binding; C:nucleus; P:negative regulation of I-kappaB kinase/NF-kappaB cascade TLE_N Groucho/TLE N-terminal Q-rich domain comp121985_c0 179.512707158 102.227727061 141.82140666 0.999999608728 MED_UP ww domain-containing oxidoreductase, ww domain-containing oxidoreductase-like P:osteoblast differentiation; P:intrinsic apoptotic signaling pathway by p53 class mediator; F:RNA polymerase II transcription coactivator activity; C:microvillus; C:Golgi apparatus; C:cytosol; P:cellular response to transforming growth factor beta stimulus; P:negative regulation of Wnt receptor signaling pathway; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; P:positive regulation of transcription from RNA polymerase II promoter; P:skeletal system morphogenesis; F:enzyme binding; C:plasma membrane; C:nucleus; C:mitochondrion TIGR01289 LPOR: light-dependent protochlorophyllide reductase comp121964_c0 0.0 0.0 12.828012469 0.99999999464 NRP_UP dna damage-binding protein 1-like isoform x1, damage specific dna binding protein 1, dna damage-binding protein 1 P:proteasomal ubiquitin-dependent protein catabolic process; P:nucleotide-excision repair, DNA damage removal; P:cell cycle checkpoint; P:Wnt receptor signaling pathway; F:damaged DNA binding; P:modulation by virus of host morphology or physiology; C:Cul4A-RING ubiquitin ligase complex; C:Cul4B-RING ubiquitin ligase complex; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; F:protein binding; C:nucleoplasm; C:cytoplasm, P:proteasomal ubiquitin-dependent protein catabolic process; P:cell cycle checkpoint; P:Wnt receptor signaling pathway; F:damaged DNA binding; P:DNA repair; C:Cul4A-RING ubiquitin ligase complex; C:Cul4B-RING ubiquitin ligase complex; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; C:cytoplasm; C:nucleus MMS1_N Mono-functional DNA-alkylating methyl methanesulfonate N-term comp122007_c0 152.516122384 301.87987647 290.374721861 1.0 MED_DOWN low quality protein: mitogen-activated protein kinase kinase kinase kinase 4-like F:small GTPase regulator activity; P:protein phosphorylation; F:protein serine/threonine kinase activity; P:regulation of JNK cascade; F:ATP binding; F:protein binding; C:cytoplasm, C:recycling endosome; F:protein binding; P:Wnt receptor signaling pathway; F:small GTPase regulator activity; C:nucleolus; P:protein autophosphorylation; F:protein serine/threonine kinase activity; C:cytoskeleton; P:activation of JNKK activity; P:actin cytoskeleton reorganization; P:regulation of dendrite morphogenesis; F:ATP binding CNH CNH domain, Pkinase Protein kinase domain comp127401_c0 79.8775929753 0.197140872139 0.0 1.0 MED_UP ubiquitin thioesterase zranb1 P:cell migration; F:ubiquitin thiolesterase activity; F:zinc ion binding; P:regulation of cell morphogenesis; F:K63-linked polyubiquitin binding; P:positive regulation of Wnt receptor signaling pathway; P:cytoskeleton organization; P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process; P:protein K63-linked deubiquitination; F:ubiquitin-specific protease activity; C:cytoplasm; C:nucleus OTU OTU-like cysteine protease