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Early social isolation stress increases addiction vulnerability to heroin and alters c-Fos expression in the mesocorticolimbic system
(Springer, 2022-01-08)Rationale Adverse psychosocial factors during early childhood or adolescence compromise neural structure and brain function, inducing susceptibility for many psychiatric disorders such as substance use disorder. Nevertheless, ... -
Opioid induces increased DNA damage in prefrontal cortex and nucleus accumbens
(Elsevier, 2023-03-14)Opioid use disorder (OUD) is a chronic disease characterized by compulsive opioid taking and seeking, affecting millions of people worldwide. The high relapse rate is one of the biggest challenges in treating opioid ... -
Insulin-like growth factor 1 regulates excitatory synaptic transmission in pyramidal neurons from adult prefrontal cortex
(Elsevier, 2022-10-01)Insulin-like growth factor 1 (IGF1) influences synaptic function in addition to its role in brain development and aging. Although the expression levels of IGF1 and IGF1 receptor (IGF1R) peak during development and decline ... -
Activity of Delafloxacin and Comparator Fluoroquinolones against Multidrug-Resistant Pseudomonas aeruginosa in an In Vitro Cystic Fibrosis Sputum Model
(MDPI, 2023-06-20)Delafloxacin (DLX) is a recently approved fluoroquinolone with broad activity against common cystic fibrosis (CF) pathogens, including multidrug-resistant Pseudomonas aeruginosa (MDR-Psa). Delafloxacin has been previously ... -
Opposing Effects of ApoE2 and ApoE4 on Glycolytic Metabolism in Neuronal Aging Supports a Warburg Neuroprotective Cascade against Alzheimer’s Disease
(MDPI, 2023-01-25)Apolipoprotein E4 (ApoE4) is the most recognized genetic risk factor for late-onset Alzheimer’s disease (LOAD), whereas ApoE2 reduces the risk for LOAD. The underlying mechanisms are unclear but may include effects on brain ... -
Evaluation of Latex Immunoturbidimetric Assay Thresholds and HIT in Cardiothoracic Surgery
(SAGE Publications, 2023-04-17)Background Heparin-induced thrombocytopenia (HIT) is a common differential diagnosis in cardiothoracic surgery. The latex immunoturbidimetric assay (LIA) is an enhanced immunoassay that has recently been introduced for ... -
Excitation-inhibition imbalance disrupts visual familiarity in amyloid and non-pathology conditions
(Cell Press, 2023-01-31)Neuronal hyperactivity induces memory deficits in Alzheimer’s disease. However, how hyperactivity disrupts memory is unclear. Using in vivo synaptic imaging in the mouse visual cortex, we show that structural excitatory-inhibitory ... -
Exposing Pharmacy Students to Public Health Concepts through Volunteering in the Medical Reserve Corps
(University of Minnesota Libraries Publishing, 2022-08-15)Pharmacy students at the University of Kansas School of Pharmacy’s regional campus were exposed to the Medical Reserve Corps (MRC), a volunteer-based network that organizes locally to improve the health and safety of their ... -
Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-Aβ interaction and Aβ fibrillation
(Elsevier, 2022-01-15)The APOE genotype is the most prominent genetic risk factor for the development of late-onset Alzheimer’'s disease (LOAD); however, the underlying mechanisms remain unclear. In the present study, we found that the sialylation ... -
Nonobese Male Patients with Alzheimer’s Disease Are Vulnerable to Decrease in Plasma Leptin
(IOS Press, 2022-08-02)Background:Metabolic dysfunction links to cognitive deficits in Alzheimer’s disease (AD). Leptin is an anti-obesity hormone that modulates energy homeostasis and memory function. Although leptin deregulation is implicated ... -
Are superficial neuromasts proprioceptors underlying fast copulatory behavior?
(Frontiers Media, 2022-08-23)In male Poeciliid fishes, the modified anal fin (i.e., gonopodium) and its axial and appendicular support are repositioned within the axial skeleton, creating a novel sexually dimorphic ano-urogenital region. During ... -
Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice
(Elsevier, 2022-09-24)Mice with constitutive disruption of the Selenop gene have been key to delineate the importance of selenoproteins in neurobiology. However, the phenotype of this mouse model is exquisitely dependent on selenium supply and ... -
M. tuberculosis Transcription Machinery: A Review on the Mycobacterial RNA Polymerase and Drug Discovery Efforts
(MDPI, 2022-11-03)Mycobacterium tuberculosis (MTB) is the main source of tuberculosis (TB), one of the oldest known diseases in the human population. Despite the drug discovery efforts of past decades, TB is still one of the leading causes ... -
Evaluation of the INCREMENT-CPE, Pitt Bacteremia and qPitt Scores in Patients with Carbapenem-Resistant Enterobacteriaceae Infections Treated with Ceftazidime–Avibactam
(Springer, 2020-02-22)Background The aim of this study was to evaluate the predictive performance of the INCREMENT-CPE (ICS), Pitt bacteremia score (PBS) and qPitt for mortality among patients treated with ceftazidime–avibactam for ... -
Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield
(Frontiers Media, 2020-04-23)Social recognition is fundamental for social decision making and the establishment of long-lasting affiliative behaviors in behaviorally complex social groups. It is a critical step in establishing a selective preference ... -
Facing Real-World Challenges of Immunogenicity in Pediatric Inflammatory Bowel Disease
(Frontiers Media, 2020-06-09)The advent of biological therapies drastically altered the landscape of inflammatory bowel disease (IBD) treatment, making long-term steroid-free remission possible for thousands of patients living with this chronic ... -
Immunogenicity in Clinical Practice and Drug Development: When is it Significant?
(Wiley Open Access, 2019-11-25)Managing immunogenicity in clinical practice and during drug development was a recent topic at the ASCPT 2019 annual meeting. This commentary expands on the discussion to facilitate a broader engagement across the community. ... -
What drugs modify the risk of iatrogenic impulse-control disorders in Parkinson’s disease? A preliminary pharmacoepidemiologic study
(Public Library of Science, 2020-01-07)Introduction Parkinson’s disease (PD) patients treated with pramipexole (PPX) and ropinirole (ROP) exhibit a higher risk of developing impulse control disorders (ICDs), including gambling disorder, compulsive shopping, ... -
The accuracy and completeness of drug information in Google snippet blocks
(Medical Library Association, 2021-10-01)Introduction: Consumers commonly use the Internet for immediate drug information. In 2014, Google introduced the snippet block to programmatically search available websites to answer a question entered into the search ... -
Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxα
(MDPI, 2021-12-07)Serotonin 1A receptors (5-HT1ARs) are implicated in the control of mood, cognition, and memory and in various neuropsychiatric disorders such as depression and anxiety. As such, understanding the regulation of 5-HT1ARs ...