RAGE: A journey from the complications of diabetes to disorders of the nervous system – striking a fine balance between injury and repair
View/ Open
Issue Date
2005Author
Rong, Ling Ling
Gooch, Clifton
Szabolcs, Mattias
Herold, Kevan C.
Lalla, Evanthia
Hays, Arthur P.
Yan, Shi Fang
Yan, Shirley ShiDu
Schmidt, Ann Marie
Publisher
IOS Press
Type
Article
Article Version
Scholarly/refereed, publisher version
Published Version
http://content.iospress.com/articles/restorative-neurology-and-neuroscience/rnn00322Metadata
Show full item recordAbstract
The Receptor for Advanced Glycation End Products (RAGE) is a multiligand member of the immunoglobulin superfamily. RAGE interacts with AGEs, the products of nonenzymatic glycation/oxidation of proteins and lipids that accumulate in diverse settings, such as diabetes, inflammation, renal failure, pro-oxidant states and natural aging. In addition, RAGE is also a receptor for amyloid-β peptide and β-sheet fibril species. Recent studies underscore the premise that RAGE interacts with pro-inflammatory molecules, including S100/calgranulins and amphoterin, the latter also known as high mobility group box 1 (HMGB1). In chronic neurodegenerative disorders as well as in nerve tissue upon acute injury, evidence points to upregulation of both RAGE and these ligand families. In this review, we will discuss the implications of transient/self-limited upregulation of RAGE and its ligands, vs sustained/chronic upregulation of this axis in neurodegeneration vs repair in both the central and peripheral nervous systems. Experimental evidence supports the premise that RAGE bears both homeostatic and injurious properties in the nervous system, thereby highlighting "yin/yang" features of this receptor and its ligand families.
Description
This is the published version. Copyright 2005 IOS Press.
Collections
- Pharmacy Scholarly Works [293]
Citation
Rong, Ling Ling, Clifton Gooch, Mattias Szabolcs, Kevan C Herold, Evanthia Lalla, Arthur P Hays, Shi Fang Yan, Shirley ShiDu Yan, Ann Marie Schmidt. "RAGE: A Journey from the Complications of Diabetes to Disorders of the Nervous System – Striking a Fine Balance between Injury and Repair." Restorative Neurology and Neuroscience 23.5, 6 (2005): 355-65. Web. 28 May 2015. Wb.
Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.