HLA Genes in Populations of the Aleutian Islands
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Issue Date
2010-10-01Author
Rey, Diego
Areces, Cristina
Parga-Lozano, Carlos
Gómez-Prieto, Pablo
Crawford, Michael H.
Arnaiz-Villena, Antonio
Publisher
Wayne State University Press
Type
Article
Article Version
Scholarly/refereed, publisher version
Published Version
http://digitalcommons.wayne.edu/humbiol/vol82/iss5/13Metadata
Show full item recordAbstract
We typed a subset of the Aleut population for HLA loci (HLA-A, HLA-B, HLA-DRB1, HLA-DQB1) to obtain an HLA profile, which was compared to other Eurasian and Amerindian populations for studying Aleut origin and its significance on the peopling of the Americas. Allele frequencies at the four loci were identified in an Aleut sample using standard indirect DNA sequencing methods. Genetic distances with Amerindians and Eurasians were obtained by comparing Aleut allele frequencies with a worldwide population database (13,164 chromosomes). The most frequently extended HLA haplotypes were also calculated. We also generated Aleut relatedness dendrograms and calculated correspondence relatedness in a multidimensional scale. Both neighbor-joining dendrograms and correspondence analysis separated Aleuts from Eskimos and Amerindians. Aleuts are closer genetically to Europeans, including Scandinavians and English. Our results are concordant with those obtained by Y-chromosome analysis, suggesting that most male Aleut ancestors of our sample came mainly from Europe.
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This is the publisher's version, also available electronically from http://digitalcommons.wayne.edu/humbiol/vol82/iss5/13/.
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Citation
Rey, Diego; Areces, Cristina; Parga-Lozano, Carlos; Gómez-Prieto, Pablo; Crawford, Michael H.; and Arnaiz-Villena, Antonio (2010) "HLA Genes in Populations of the Aleutian Islands," Human Biology: Vol. 82: Iss. 5-6, Article 13. http://digitalcommons.wayne.edu/humbiol/vol82/iss5/13
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